The Gregory Lab @ DukeU's Avatar

The Gregory Lab @ DukeU

@gregorylab.bskyverified.social

The Gregory lab @DukeU studies disease mechanism using scRNAseq & spatial molecular technologies. Focus on brain tumors, Alzheimer's and MS 🧠 Home to the Molecular Genomics Core (MGC) - https://dmpi.duke.edu/cores/molecular-genomics-core-mgc

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Latest posts by The Gregory Lab @ DukeU @gregorylab.bskyverified.social

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Presenting the #DukeMGC poster from #AGBT26

'Beyond 'Black Box' Analysis: A platform-agnostic guide for non-formalin fixed #SingleCell RNA sequencing'

For more information, check out our preprint: www.biorxiv.org/content/10.6...

09.03.2026 18:21 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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#AGBT26 was ex-cell-ent! Thank you to @agbt.bsky.social for another great meeting. We're already counting down the days to next year... 🧬

06.03.2026 18:48 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Today, #DukeMGC's Ellora Haukenfrers presented at #DukeSCIRIP 'A platform-agnostic evaluation of non-formalin fixed single cell RNA technologies'

Interested in learning more? Check out our preprint: www.biorxiv.org/content/10.6...

Learn more about SCIRIP: dmpi.duke.edu/duke-single-...

04.03.2026 21:33 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Happening next Wednesday!

27.02.2026 14:56 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

This afternoon, come check out #DukeMGC data at #AGBT26 4:45-6:15, poster #472!!

25.02.2026 15:40 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Day 1 of #AGBT26 was awesome! #DukeMGC's Karen & VJ are ready to rock out for and talk science for the rest of the week 🧬🎸😁

25.02.2026 15:39 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Check out our poster at #AGBT26 today 1:30-3:30, poster #401!

24.02.2026 13:37 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Next #DukeSCIRIP seminar is March 4th 12-1pm online or in MSRBIII!

Join us for talks on ongoing research in #SpatialTranscriptomics and #SingleCell at Duke, this month from the Ji lab and #DukeMGC🧬

For more info or to join virtually, please visit dmpi.duke.edu/duke-single-...

23.02.2026 17:24 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1
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Work from the #DukeMGC will be on display at #AGBT2026:

Tuesday 1:30-3:30, poster #401

Wednesday 4:45-6:15, poster #472

Come find us to chat about our data! 🧬

#AGBT #SpatialTranscriptomics #SingleCell #Benchmarking #LongReadSequencing

20.02.2026 15:27 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 2
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Spatial omics at the forefront: emerging technologies, analytical innovations, and clinical applications Liu et al. review how spatial omics technologies reveal the organization, interaction, and evolution of tumor cells and their microenvironment within tissues. They highlight analytical advances that t...

Recent review from HTAN. Linghua Wang with a timely review on spatial omic technologies Cancer Cell. www.cell.com/cancer-cell/...

26.01.2026 17:31 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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We are thrilled to share the 1st pub out of the #DukeMGC. Congrats to Lab Analyst Ellora Haukenfrers' on your 1st first author paper!

We present 'A platform-agnostic evaluation of non-formalin fixed #singlecell RNA technologies'

#benchmarking #scRNAseq
www.biorxiv.org/content/10.6...

29.01.2026 02:42 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Upcoming on Feb 4, the next #DukeSCIRIP seminar! Featuring talks from Lauren Parker of the Karra lab & Hamayl Afzal.

For more information or to contact #DukeSCIRIP, please visit out website: dmpi.duke.edu/duke-single-...

20.01.2026 17:37 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...

13.01.2026 16:25 πŸ‘ 36 πŸ” 18 πŸ’¬ 2 πŸ“Œ 2
POSTDOCTORAL ASSOCIATE POSTDOCTORAL ASSOCIATE

I am recruiting a postdoc focused on analysis of 'omic' data with the goal of identifying cell types that modulate GBM predisposition.

An ideal candidate would have expertise in analysis of:
β€’ Single cell/spatial sequencing.
β€’ Bulk RNA
β€’ WXS
β€’ Genotyping array.

careers.duke.edu/job/Durham-P...

09.01.2026 16:10 πŸ‘ 2 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Evaluating the practical aspects and performance of commercial single-cell RNA sequencing technologies Abstract. The rapid development of updated and new commercially available single-cell transcriptomics platforms provides users with a range of experimental

academic.oup.com/nargab/artic...

09.01.2026 00:33 πŸ‘ 6 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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That's a wrap on another year in the Gregory lab! 2025 was filled with many hours of hard work in the lab & R Studio, with some fun along the way.

Cheers to 2026 from all of us - we can't wait to show you what we've been working on this year! πŸ₯‚πŸ§¬πŸ§ 

#SingleCell #SpatialOmics

30.12.2025 16:33 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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"using single-cell transcriptomes from 1,271 patients across 26 cancer types, we compile a TME cellular atlas, leading to the identification of recurrent cell states and multicellular modules across cancer types." www.biorxiv.org/content/10....

30.12.2025 15:15 πŸ‘ 14 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Happy Holidays from the Gregory Lab πŸŽ€πŸ₯‚

26.12.2025 14:03 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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January 7th 2-1pm in MSRBIII or online, #DukeSCIRIP seminar series continues!

@epigenometech.bsky.social's Chris Hartle will be presenting the talk 'β€˜Deciphering Single-Cell Chromatin Landscapes in the Human Immune System: A First Look’ 🧬

For more information: dmpi.duke.edu/duke-single-...

19.12.2025 20:17 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Yesterday, the Gregory lab had our annual holiday lunch & white elephant gift exchange

A great time was had by all! After all, we have holiday cheer in our DNA (and on our lab cart)πŸ§¬πŸŽ„πŸ•Ž

17.12.2025 21:15 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Today, #DukeMGC gave a talk & poster presentation on our available services at the #Duke Precision Genomics Collaboratory! We love the opportunity to share the work we do... 🧬🧠

Interested in learning more about MGC services? Please visit our website: dmpi.duke.edu/cores/molecu...

12.12.2025 19:27 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Lauren also got the chance to catch up with her old lab (#HugoGuerreroLab)! It was great to see familiar faces, picturesque scenery & exciting new #NeuroOncology developments

09.12.2025 15:02 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Gregory lab #PhD student, Lauren Whaley Powers, attended #SNO25 in beautiful Honolulu & presented her poster:

'Integrative #SingleNuclei #SpatialTranscriptomic profiling of primary and recurrent human #GBM reveals cell-type specific #EGFRvIII expression & #ANXA1 signaling axis' πŸ§ πŸ§¬πŸ”¬πŸ’»πŸŒΊ

09.12.2025 14:58 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1
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Multi-region spatial transcriptomics reveals region specific differences in response to amyloid beta (AΞ²) plaque induced changes in Alzheimer's disease (AD) - PubMed Our results demonstrate the value of simultaneously profiling AD-omic and spatial modalities in multiple regions to elucidate how cortical region-specific differences contribute to selective vulnerability and resilience during neurodegeneration. These cortical region and AΞ² microenvironment-specific …

New publication by our student, Odmaa Bayaraa: 'Multi-region #SpatialTranscriptomics reveals region specific differences in response to amyloid beta (AΞ²) plaque induced changes in #Alzheimers disease (#AD)'

So proud of this work and of Odmaa! Check it out 🧬🧠
pubmed.ncbi.nlm.nih.gov/41318546/

08.12.2025 13:47 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets - Nature Biotechnology A multi-institute, multi-platform initiative generates standard metrics and best practices for spatial transcriptomics analysis.

www.nature.com/articles/s41...

03.12.2025 15:25 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

We are looking for a bioinformatics postdoc to join our group! Apply here πŸ‘‡πŸ‘‡πŸ‘‡

www.jobs.ac.uk/job/DPQ109/p...

01.12.2025 11:14 πŸ‘ 2 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Happening next week!!

28.11.2025 18:28 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Join us:

With @abigailsuwala.bsky.social we are looking for a postdoc to drive our spatial transcriptomics analysis efforts of brain tumours.

If you enjoy multidisciplinary biomedical research, big data and coding, you are in the right place.

karriere.klinikum.uni-heidelberg.de/index.php?ac...

28.11.2025 14:11 πŸ‘ 9 πŸ” 7 πŸ’¬ 0 πŸ“Œ 1
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Last week, Gregory lab #PhD student Emma Hatchell attended @sfn.org #Sfn2025 in beautiful San Diego and presented a poster!

"Spatial Profiling of #Herpesvirus Transcripts in #MultipleSclerosis Spinal Cord Lesions Using #Xenium In Situ Analysis" 🧬

24.11.2025 19:53 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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12/3 12-1pm in MSRBIII or online, #DukeSCIRIP seminar series continues!

Feat. talks from Shane O'Neil of the @filianolab.bsky.social and Huifang Ma of the #DukeBiostats Ji lab 🧬

Interested in attending virtually or presenting? Visit our webpage for more information: dmpi.duke.edu/duke-single-...

20.11.2025 18:52 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1