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Nature Reviews Nephrology

@natrevneph.nature.com

Publishing reviews and commentaries across the field of nephrology. Posts are from the editors. www.nature.com/nrneph/

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Posts 19.11.2024
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Latest posts by Nature Reviews Nephrology @natrevneph.nature.com

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Chronic Kidney Disease: Emerging Mechanisms, Consequences and Targeted Treatments | Keystone Symposia Join us at the Keystone Symposia on Chronic Kidney Disease: Emerging Mechanisms, Consequences and Targeted Treatments, April 2026, in Vancouver, with field leaders!

If you can't make it in person, register now for Livestream and On Demand Access to @keystoneSymposia.bsky.social Chronic #KidneyDisease : Mechanisms, Consequences & Treatments, this April to explore emerging research! hubs.la/Q045r2FV0 #KSKidney26

10.03.2026 15:52 👍 0 🔁 0 💬 0 📌 0
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Chronic Kidney Disease: Emerging Mechanisms, Consequences and Targeted Treatments | Keystone Symposia Join us at the Keystone Symposia on Chronic Kidney Disease: Emerging Mechanisms, Consequences and Targeted Treatments, April 2026, in Vancouver, with field leaders!

Explore emerging research with leaders in the field @keystoneSymposia.bsky.social Chronic #KidneyDisease : Mechanisms, Consequences & Treatments, this April in Vancouver! keysym.us/KSKidney26 #KSKidney26 hubs.la/Q045r2FV0

10.03.2026 15:21 👍 0 🔁 0 💬 0 📌 0
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Women’s health Research into women’s health has suffered from historical neglect and lack of funding.

To mark International Women's Day on 8th March #IWD2026, the #NatureReviews Collection on women's health has been updated (go.nature.com/30kDWG3). The Collection covers various aspects of women's health and includes a new Primer on ovarian cancer from @natrevdiseaseprimers.nature.com

06.03.2026 12:19 👍 15 🔁 13 💬 0 📌 0
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In our March issue: Reviews on the global burden of AKI; cell–cell crosstalk; natural killer cells; and the glomerular endothelial glycocalyx as a therapeutic target, plus a series of Comment articles on planetary health for World Kidney Day go.nature.com/4b7lkyc

24.02.2026 03:52 👍 0 🔁 0 💬 0 📌 0
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Nature Medicine Commission on dialysis policy in low- and middle-income countries Chronic kidney disease represents a growing global health challenge and people progressing to kidney failure rely on dialysis – but access is limited in many ...

This online collection from our friends at Nature Medicine includes their Commission Report on dialysis policy in low- and middle-income countries along with linked research articles, reviews and commentaries from across the Nature Portfolio. go.nature.com/4t736Ed

30.01.2026 00:31 👍 1 🔁 1 💬 0 📌 0
A depiction of the Two-Eyed Seeing framework

A depiction of the Two-Eyed Seeing framework

In our February issue: Reviews on kidney health across Indigenous populations; the use and limitations of hPSCs; and the genetics of hypertension. A Perspectives on spatial metabolomics plus six Year-in-Review articles summarizing the highlights of 2025 go.nature.com/3Mavp3S

28.01.2026 03:10 👍 2 🔁 0 💬 0 📌 0
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Nature Medicine Commission on dialysis policy in low- and middle-income countries Chronic kidney disease represents a growing global health challenge and people progressing to kidney failure rely on dialysis – but access is limited in many ...

Check out the Nature Medicine Commission on dialysis policy in low- and middle-income countries! @natmed.nature.com

www.nature.com/collections/...

22.01.2026 09:57 👍 2 🔁 0 💬 0 📌 0
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⚡Our January issue is live! Including the first Nature Medicine Commission Report (introduced in our Editorial), new research on #infertility, #huntingtonsdisease, #cancer #cachexia, #HIV, #genetherapy, #microbiome therapy, News & Opinion and much more
https://www.nature.com/nm/volumes/32/issues/1

21.01.2026 16:50 👍 8 🔁 2 💬 1 📌 0
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Strengthening kidney care through evidence-informed participatory policymaking Nature Reviews Nephrology, Published online: 21 January 2026; doi:10.1038/s41581-025-01032-2Dialysis is among the most cost-intensive health services available; however, its availability is often shaped by competing interests among providers, payers, industry and patients. Thailand’s experience in aligning these interests offers valuable lessons for countries that are striving to expand equitable kidney care within limited fiscal space and progress towards universal health coverage.
21.01.2026 21:52 👍 1 🔁 1 💬 0 📌 0
Sustainable AI in medicine: balancing benefits and environmental costs Nature Reviews Nephrology, Published online: 15 January 2026; doi:10.1038/s41581-026-01047-3Artificial intelligence (AI) and deep learning could have a transformative effect on healthcare. However, this technology has a high carbon footprint, requires the use of natural resources and generates electronic waste. Consideration of the environmental impact raises ethical questions that must be addressed to enable sustainable use of AI in medicine.
21.01.2026 09:39 👍 0 🔁 0 💬 0 📌 0
Environmentally sustainable kidney care in low- and middle-income countries Nature Reviews Nephrology, Published online: 20 January 2026; doi:10.1038/s41581-026-01051-7Low- and middle-income countries face a rapidly increasing prevalence of chronic kidney disease in a setting of limited resources and heightened environmental vulnerabilities. Disease prevention strategies, optimization of kidney replacement therapies, technological innovations and adaptation of health policies to local realities is required to enable resilient and sustainable kidney care.
20.01.2026 21:47 👍 0 🔁 0 💬 0 📌 0
Health risks of oil and gas development Nature Reviews Nephrology, Published online: 20 January 2026; doi:10.1038/s41581-026-01050-8An increasing body of evidence has highlighted direct and indirect health implications of oil and gas expansion. Nations that produce oil, gas and petrochemicals must stop placing short-term interests above the health and future of humanity.
20.01.2026 21:47 👍 0 🔁 0 💬 0 📌 0
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Climate change and AKI: heat, hazards and health-system readiness Nature Reviews Nephrology, Published online: 14 January 2026; doi:10.1038/s41581-026-01048-2Climate change is increasing the risk of acute kidney injury owing to heat stress, infectious and vector-borne diseases, food and water insecurity, pollution and nephrotoxins. Outdoor workers and underserved communities are most affected. Proactive prevention strategies, pathogen-specific care and climate-resilient kidney services can avert avoidable injury, narrow inequities and save lives.
20.01.2026 09:36 👍 1 🔁 1 💬 0 📌 0
Environmental stewardship and health systems: Indigenous-centred reflections Nature Reviews Nephrology, Published online: 14 January 2026; doi:10.1038/s41581-026-01049-1Environmental sustainability movements have faced criticism for their often mechanical, anthropocentric approach that maintains standards of overconsumption within healthcare and has perpetuated planetary harm. Environmental stewardship, as practised within many Indigenous communities, instead focuses deeply on the interconnectedness of human and planetary health, and offers insights from which the health community can learn.
20.01.2026 09:36 👍 0 🔁 0 💬 0 📌 0
Disentangling the role of environmental factors in the CKDu epidemic Nature Reviews Nephrology, Published online: 19 January 2026; doi:10.1038/s41581-026-01054-4Chronic kidney disease of unknown origin (CKDu) has been reported in various tropical settings over the past 20 years, but clarity on key disease drivers is lacking. Several factors have slowed progress in understanding this disease or diseases, including low research funding, difficult case definition and multiple risk factors for kidney disease.
20.01.2026 02:27 👍 2 🔁 1 💬 0 📌 0
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Next-generation therapeutics for diabetic kidney disease Nature Reviews Nephrology, Published online: 12 January 2026; doi:10.1038/s41581-025-01042-0In this Review, the authors discuss guideline-directed medical therapy for diabetic kidney disease and the evolving clinical evidence for next-generation therapies, including incretin-based therapies, endothelin receptor antagonists, aldosterone synthase inhibitors, soluble guanylate cyclase agonists and anti-inflammatory therapies.
18.01.2026 09:34 👍 2 🔁 1 💬 0 📌 0
Sustainable AI in medicine: balancing benefits and environmental costs Nature Reviews Nephrology, Published online: 15 January 2026; doi:10.1038/s41581-026-01047-3Artificial intelligence (AI) and deep learning could have a transformative effect on healthcare. However, this technology has a high carbon footprint, requires the use of natural resources and generates electronic waste. Consideration of the environmental impact raises ethical questions that must be addressed to enable sustainable use of AI in medicine.
15.01.2026 21:38 👍 1 🔁 0 💬 0 📌 0
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Climate change and AKI: heat, hazards and health-system readiness Nature Reviews Nephrology, Published online: 14 January 2026; doi:10.1038/s41581-026-01048-2Climate change is increasing the risk of acute kidney injury owing to heat stress, infectious and vector-borne diseases, food and water insecurity, pollution and nephrotoxins. Outdoor workers and underserved communities are most affected. Proactive prevention strategies, pathogen-specific care and climate-resilient kidney services can avert avoidable injury, narrow inequities and save lives.
14.01.2026 21:35 👍 3 🔁 0 💬 0 📌 0
Environmental stewardship and health systems: Indigenous-centred reflections Nature Reviews Nephrology, Published online: 14 January 2026; doi:10.1038/s41581-026-01049-1Environmental sustainability movements have faced criticism for their often mechanical, anthropocentric approach that maintains standards of overconsumption within healthcare and has perpetuated planetary harm. Environmental stewardship, as practised within many Indigenous communities, instead focuses deeply on the interconnectedness of human and planetary health, and offers insights from which the health community can learn.
14.01.2026 21:35 👍 1 🔁 0 💬 0 📌 0
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GLP-1 receptor agonists and next-generation metabolic hormone therapies in chronic kidney disease Nature Reviews Nephrology, Published online: 08 January 2026; doi:10.1038/s41581-025-01036-yTargeting incretins is emerging as an effective approach to treat cardiovascular–kidney–metabolic syndrome. Here, the authors examine the biological effects of incretins and other metabolic hormones, such as glucagon and amylin, as well as discussing current clinical data demonstrating the organ-protective effects of incretin drugs and their potential underlying mechanisms.
14.01.2026 05:59 👍 1 🔁 0 💬 0 📌 0
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Next-generation therapeutics for diabetic kidney disease Nature Reviews Nephrology, Published online: 12 January 2026; doi:10.1038/s41581-025-01042-0In this Review, the authors discuss guideline-directed medical therapy for diabetic kidney disease and the evolving clinical evidence for next-generation therapies, including incretin-based therapies, endothelin receptor antagonists, aldosterone synthase inhibitors, soluble guanylate cyclase agonists and anti-inflammatory therapies.
12.01.2026 21:33 👍 2 🔁 0 💬 0 📌 0
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Multifactorial chronic kidney disease and the kidney capacity–workload balance Nature Reviews Nephrology, Published online: 05 January 2026; doi:10.1038/s41581-025-01038-wIn this Perspective, the authors explore the concept of multifactorial chronic kidney disease and examine the different factors that might compromise kidney functional capacity or increase kidney workload throughout the life-course, and how their cumulative effects can lead to chronic kidney disease.
11.01.2026 21:44 👍 1 🔁 0 💬 0 📌 0
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Quality-oriented diet therapy for chronic kidney disease Nature Reviews Nephrology, Published online: 05 January 2026; doi:10.1038/s41581-025-01034-0Here, the authors discuss how to implement quality-focused dietary strategies for patients with chronic kidney disease. They discuss the principles of dietary balance, variety and moderation, food processing and cooking methods and approaches to enabling successful implementation of quality-focused dietary strategies.
11.01.2026 21:44 👍 1 🔁 1 💬 0 📌 0
Preview
GLP-1 receptor agonists and next-generation metabolic hormone therapies in chronic kidney disease Nature Reviews Nephrology, Published online: 08 January 2026; doi:10.1038/s41581-025-01036-yTargeting incretins is emerging as an effective approach to treat cardiovascular–kidney–metabolic syndrome. Here, the authors examine the biological effects of incretins and other metabolic hormones, such as glucagon and amylin, as well as discussing current clinical data demonstrating the organ-protective effects of incretin drugs and their potential underlying mechanisms.
08.01.2026 17:58 👍 0 🔁 0 💬 0 📌 0
Preview
Multifactorial chronic kidney disease and the kidney capacity–workload balance Nature Reviews Nephrology, Published online: 05 January 2026; doi:10.1038/s41581-025-01038-wIn this Perspective, the authors explore the concept of multifactorial chronic kidney disease and examine the different factors that might compromise kidney functional capacity or increase kidney workload throughout the life-course, and how their cumulative effects can lead to chronic kidney disease.
06.01.2026 09:42 👍 1 🔁 0 💬 0 📌 0
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Quality-oriented diet therapy for chronic kidney disease Nature Reviews Nephrology, Published online: 05 January 2026; doi:10.1038/s41581-025-01034-0Here, the authors discuss how to implement quality-focused dietary strategies for patients with chronic kidney disease. They discuss the principles of dietary balance, variety and moderation, food processing and cooking methods and approaches to enabling successful implementation of quality-focused dietary strategies.
06.01.2026 09:42 👍 0 🔁 0 💬 0 📌 0
Toward an understanding of the intrinsic kidney response to acute injury Nature Reviews Nephrology, Published online: 17 December 2025; doi:10.1038/s41581-025-01045-xKidneys are highly susceptible to acute injury. Several studies in 2025 revealed insights into mechanisms of protection and susceptibility — including sex-specific mechanisms of protection against ferroptosis, mechanisms of impaired resilience imparted by mitochondrial DNA mutations, and a role for tRNA-Asp-GTC-3′tDR in RNA autophagy — that provide new directions for diagnostic tools and therapies for acute kidney injury.
23.12.2025 04:34 👍 1 🔁 2 💬 0 📌 0
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Advances in risk prediction and treatment strategies for CKM syndrome Nature Reviews Nephrology, Published online: 16 December 2025; doi:10.1038/s41581-025-01044-yCardiovascular–kidney–metabolic (CKM) syndrome reflects the intricate connections between metabolic disorders, chronic kidney disease and cardiovascular disease. In 2025, key studies advanced understanding of risk prediction in CKM syndrome, including the role of social determinants of health, as well as combination treatment strategies and potential therapeutic targets to improve CKM health.
22.12.2025 17:29 👍 1 🔁 0 💬 0 📌 0
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Interactive exploration of multimodal spatial data with FUSION Nature Reviews Nephrology, Published online: 15 December 2025; doi:10.1038/s41581-025-01043-zIn this Tools of the Trade article, Nicholas Lucarelli (Computational Microscopy Imaging Lab, directed by Pinaki Sarder) describes the development of FUSION, a cloud-based platform for the integration of histology and spatial -omics data.
21.12.2025 17:20 👍 0 🔁 0 💬 0 📌 0
Toward an understanding of the intrinsic kidney response to acute injury Nature Reviews Nephrology, Published online: 17 December 2025; doi:10.1038/s41581-025-01045-xKidneys are highly susceptible to acute injury. Several studies in 2025 revealed insights into mechanisms of protection and susceptibility — including sex-specific mechanisms of protection against ferroptosis, mechanisms of impaired resilience imparted by mitochondrial DNA mutations, and a role for tRNA-Asp-GTC-3′tDR in RNA autophagy — that provide new directions for diagnostic tools and therapies for acute kidney injury.
17.12.2025 16:33 👍 0 🔁 0 💬 0 📌 0