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Dan Polyak

@polym0n

Senior Scientist @Merck | PhD @Brandeis | synthetic chemist | currently loving gardening, exploring nature, looking at birds, crocheting, and petting my cats

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19.09.2023
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Latest posts by Dan Polyak @polym0n

Awesome shot!

15.02.2026 14:45 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

The Severance Package

30.12.2025 16:15 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Ok here it is - out of 44 FDA approvals this year, 31 are small molecules (70%), 26 of those are oral drugs (84%), 22 of them are chiral (71%). This is the largest number and percentage of chiral FDA approved molecules in a single year. Fitusiran is not a small molecule, bonus.

30.12.2025 12:56 ๐Ÿ‘ 74 ๐Ÿ” 33 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 1
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Got a plot at my local community garden and it has been such a pleasant experience. Trying out Square Foot Gardening, not sure how the harvest is going to turn out but at least it looks pretty

04.05.2025 13:29 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Life imitates art

05.04.2025 01:50 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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If you're interested in a break from the doom-and-gloom, may I recommend our article, online today @nature.com

A solution to the pyrazole alkylation problem, leveraging S-to-NR atom replacement. Skeletal editing has strategic value, outside of late-stage!

www.nature.com/articles/s41...

03.04.2025 16:27 ๐Ÿ‘ 137 ๐Ÿ” 26 ๐Ÿ’ฌ 7 ๐Ÿ“Œ 2