Jesse

anyway congratulations seasonal depression gang we survived another winter

I know that sounds ridiculously tiny, but in very sensitive people I think that could have meaningful effects without intolerable side effects, like severe anxiety.

I'm not sure what a better, but practical, idea here is because the patch delivery is more ideal. It would keep the amount of medicine in one's system very stable. The patches are commercially made. Ideally maybe you could have a 1 mcg or 0.5 mcg/hour patch. (24 or 12 mcg per day).

Thinking about how the transdermal patch, even the lowest dose of 5 mcg/hour, is probably not gentle enough for extremely sensitive plural systems. If for example, you don't tolerate 10 mcg naltrexone during the day, then 120 mcg buprenorphine per day is probably going to overwhelm your system.

If I hadn't felt safe to share what was going on with me with a new provider I really don't think I would've gotten diagnosed with celiac. And for me, that's been a huge improvement in my baseline mental health too. Mental and physical health are all connected.

In my own case, buprenorphine helped me feel socially safe and I am able to share more. This has had direct positive impacts on my physical health. The biggest example being that I was diagnosed with celiac less than a year after I was on buprenorphine for my BPD.

Not treating "difficulty with vulnerability" can have serious negative consequences. Such as in this case, if it feels too unsafe to share symptoms with your doctor, you are unlikely to be able to access necessarily health care.

Difficulty being vulnerable can be a symptom of BPD and it can also be a challenge for traumatized people. We see a lot of overlap between BPD and CPTSD in some cases where both are impacting relationships and expressing emotions.

I'm hoping to see another anecdotal improvement in someone very close to me soon. The most challenging part it seems like is providing a sufficient reason for even a temporary trial in most cases.

In my PCP guide, I've included a randomized controlled trial that ended up having a subgroup of BPD participants for reduction in suicidality, who responded even better than the participants without BPD, and the only case study I'm aware of currently of using buprenorphine for treatment of BPD.

All of this is still very early work. There aren't a bunch of studies out there connecting these dots, so it's based on a few studies that show buprenorphine's use in severe suicidality and depression, along with theoretical outcomes based on receptor function.

Working on my PCP guide for using buprenorphine for BPD this week I feel like has gotten me a lot closer to unifying its use for trauma-based disorders (such as CPTSD and dissociative disorders).

Tech Companies Shouldn’t Be Bullied Into Doing Surveillance The Secretary of Defense has given an ultimatum to the artificial intelligence company Anthropic in an attempt to bully them into making their technology available to the U.S. military without any res...

The Department of Defense is reportedly offering Anthropic an ultimatum: let us use your technology for whatever we want, or else. No company should be forced to be a tool of civil liberties violations.

Here’s the chart that shows how Rx opioids DIDN’T fuel the overdose epidemic. It’s illicit fentanyl. It has been since 2016.
Our country has been destabilized by an administration that allowed new analogs to proliferate, while killing #chronicpain patients. Now they’re back. (CDC data)
#Disabled

When I was estrogen-based, I definitely had more issues with my mood before my period, but I thought that was ✨dysphoria✨ (of the gender kind), in retrospect.

Maybe others will think this is obvious, but it was very interesting for me to learn. What if it's more than PMDD?

I recently learned that endogenous opioid tone varies with estrogen levels, lowest when estrogen is lowest.

For anyone whose estrogen fluctuates (anyone on E) and has BPD/CPTSD:

Do your biggest emotional crashes tend to happen when estrogen is lowest? (For some, that’s right before a period.)

This crap has absolutely nothing to do with protecting children and everything to do with forcing people to give up their privacy and data to companies like Palantir.

Autism & BPD An exploration of how autism, chronic developmental stress, and trauma may converge through the endogenous opioid system, offering a biological framewor...

Opioid-System Epigenetics as a Bridge Between Autism and BPD

How shared changes in the endogenous opioid system may help explain overlap in attachment patterns, emotional pain sensitivity, and stress responsivity.

bpd.fyi/autism-and-b...

#ActuallyAutistic #Neurodivergent

Plain-Language Overview A plain-language explanation of what transdermal buprenorphine might mean for plural systems, including switching, amnesia, and integration concerns.

Just published a shorter, more accessible post on what transdermal buprenorphine might mean for people with dissociative disorders and borderline traits.

It focuses on practical effects like switching, amnesia, and integration concerns.

bpd.fyi/buprenorphin...

I've been spending a lot of time writing up a PCP guide too and I'm going to be looking for reviewers soon.

I wrote up a much shorter, and hopefully more accessible, post about theoretical changes you could anticipate seeing using transdermal buprenorphine for dissociative disorders with borderline traits. I'll try to get it posted today.

Someone close to me with DID and high borderline traits is considering this treatment with their clinician. I’m curious what we’ll learn, but that would still be anecdotal, not evidence.

Just to clarify, my experience is with BPD. I don’t have structural dissociation or daily dissociative impairment. My discussion of plural systems is theoretical and based on mechanism and limited data, not lived experience with DID/OSDD.

That’s a valid concern. I didn’t personally experience emotional flattening at my dose, but it is reported at higher doses, and very sensitive people could potentially feel it even at lower ones. If borderline traits aren’t present, ultra-low-dose naltrexone may be a lower-risk place to start.

Theoretically, yes. It could translate to more shared memory and a greater sense of control, but it’s still largely hypothetical. I’d want more clinical evidence before being definitive. We have seen similar outcomes with ultra-low-dose naltrexone when borderline traits aren’t present.

It’s not about forcing integration. The hypothesis is that steadier baseline opioid signaling may reduce stress-driven dissociation and support greater co-consciousness between headmates. Any integration would remain a therapeutic choice, not something medication imposes.

Thanks for asking this. These are important concerns. There’s no direct clinical research on transdermal buprenorphine in plural systems. What I’m describing is a theoretical model based on buprenorphine’s mechanisms, low/ultra-low-dose naltrexone data, and one anecdotal case.

IF YOU'RE UNEMPLOYED IT'S NOT BECAUSE THERE ISNT ANY WORK JUST LOOK AROUND: A HOUSING SHORTAGE, CRIME, POLLUTION; WE NEED BETTER SCHOOLS AND PARKS. WHATEVER OUR NEEDS, THEY ALL REQUIRE WORK. AND AS LONG AS WE HAVE UNSATISFIED NEEDS, THERE'S WORK TO BE DONE. SO ASK YOURSELE, WHAT KIND OF WORLD HAS WORK BUT NO JOBS. IT'S A WORLD WHERE WORK IS NOT RELATED TO SATISFYING OUR NEEDS, WORLD WHERE WORK IS ONLY RELATED TO SATISFYING THE PROFIT NEEDS OF BUSINESS. THIS COUNTRY WAS NOT BUILT BY THE HUGE CORPORATIONS OR GOVERNMENT BUREAUCRACIES. IT WAS BUILT BY PEOPLE WHO WORK. AND, IT IS WORKING PEOPLE WHO SHOULD CONTROL THE WORK TO BE DONE. YET, AS LONG AS EMPLOYMENT IS TIED TO SOMEBODY ELSE'S PROFITS, THE WORK WONT GET DONE.

the Black Panthers were right