The International Society for Clinical Spectroscopy

A member of our steering Council, Anita Mahadevan-Jansen, spotlighted by @nature.com as an inspiring Woman in Science on International Women's Day #IWD2026.

Anita is co-hosting our SPEC 2026 conference in May, so why not sign up and be inspired too!
www.spec2026.org

📢Abstract deadline for SPEC 2026 is February 16!!

Registration now open

Visit www.spec2026.org for everything you need to know!

See you in Nashville!

Keynote speakers at @springscix2026.bsky.social include

Prof Yasuyuki Ozeki (University of Tokyo)
Prof Iwan Schie (Jena)
Dr Renzo Vanna (CNR-IFN)
Dr Federico Vernuccio (Institute Fresnel)

Keynote speakers at @springscix2026.bsky.social include

Dr Lucy Flint (AstraZeneca)
Prof Katsumasa Fujita (University of Osaka)
Prof Mako Kamiya (Institute of Science Tokyo)
Prof Oxana Klementieva (Lund University)
Prof Julian Moger (University of Exeter)

more...

Keynote speakers at @springscix2026.bsky.social include

Prof Ishan Barman (John Hopkins University)
Dr Georgina Charlton (UCL)
Dr Priyanka Dey (University of Portsmouth)
Dr Kareem Elsayad (Medical University of Vienna)
Dr Dougal Ferguson (University of Manchester)

more...

Plenary speakers at @springscix2026.bsky.social

Prof Thomas Bocklitz (Jena)
Prof Sarah Bohndiek (Cambridge University)
Prof Bernhard Lendl (TU Wien)

Abstract deadline for @springscix2026.bsky.social coming up on Friday!

Registration now open...

Some great keynote speakers to add to the great plenaries!

Check out the website here: springscix.org

Exploring Fourier-Transform Infrared Microscopy for Scabies Mite Detection in Human Tissue Sections: A Preliminary Technical Feasibility Study.

Int. J. Mol. Sci. 2025, 26(23), 11597;
doi.org/10.3390/ijms...

#infrared #openaccess

🎉Spring SciX 2026 abstract submissions are now open! 🎉

Use forms.office.com/e/yvHNkMkDBU to submit your abstract

⚠️Submissions close Friday 30th January 2026 ⚠️

@profnickstone.bsky.social @arasfly3.bsky.social

DisentangleFormer: Spatial-Channel Decoupling for Multi-Channel Vision Vision Transformers face a fundamental limitation: standard self-attention jointly processes spatial and channel dimensions, leading to entangled representations that prevent independent modeling of s...

Preprint funded from the CLIRPath-AI grant (clirpath-ai.org)

DisentangleFormer: Spatial-Channel Decoupling for Multi-Channel Vision
arxiv.org/abs/2512.04314

The Infrared and Raman Discussion Group (IRDG) | The Infrared and Raman Discussion Group

🚨Sessions Announced 🚨
• Plasmonics and nanomaterials
• IRDG Martin & Willis
• Frontiers in IR
• Handheld spectroscopy
• Process analytical control

www.irdg.org @karenfaulds.bsky.social

From Single Molecular Detail to Subcellular Dynamics: Real-Time Kinetics Study of dPA Uptake with Raman-based Spectroscopy Real-time observation of cellular transformations at the subcellular level provides insight into the dynamic biochemical processes underlying cell function and disease. However, many challenges remain...

From Single Molecular Detail to Subcellular Dynamics: Real-Time Kinetics Study of dPA Uptake with Raman-based Spectroscopy.

bioRxiv 2025.11.21.689687
doi.org/10.1101/2025...

#preprint #ramaneffect #openaccess

Raman spectroscopy supported by machine learning reveals changes in balance of macromolecules in diabetic rat serum - Analytical and Bioanalytical Chemistry In type 2 diabetes mellitus (T2DM), changes in glucose and lipid levels in serum are the first signals of disease progression. In this article, Raman spectroscopy supported with machine learning (ML) ...

Raman spectroscopy supported by machine learning reveals changes in balance of macromolecules in diabetic rat serum.

Anal Bioanal Chem 417, 6655–6663 (2025). doi.org/10.1007/s002...

#ramaneffect #diabetes #openaccess

Fix or Freeze? Spectral Differences Arising from Tissue Preparation in Chemical Imaging Spectrochemical imaging has emerged as a powerful, label-free modality for visualizing the bio-chemical composition of tissues based on intrinsic vibrational signatures. Specifically, mid-infrared spe...

Fix or Freeze? Spectral Differences Arising from Tissue Preparation in Chemical Imaging

bioRxiv 2025.11.19.689284
doi.org/10.1101/2025...

#preprint #infrared #openaccess

Application of Raman and ATR-MIR Spectroscopy in Colorectal Cancer Diagnosis Combined with Chemometrics Techniques: A Review Colorectal Cancer (CC) is recognized as the third most prevalent cancer worldwide and constitutes a major cause of cancer-related fatalities among both genders. Current diagnostic approaches for CC...

Application of Raman and ATR-MIR Spectroscopy in Colorectal Cancer Diagnosis Combined with Chemometrics Techniques: A Review.
Critical Reviews in Analytical Chemistry, 1–22.
doi.org/10.1080/1040...

#infrared #atrir #coloncancer #cancer #review

FTIR-based profiling of sinusitis: Stabilized feature selection through Boruta and Monte Carlo methods.

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Volume 345, 15 January 2026, 126779
doi.org/10.1016/j.sa...

#infrared

Lymphocytes in infectious mononucleosis analyzed by Raman microspectroscopy.
Journal of Molecular Structure
Volume 1352, Part 2, 15 February 2026, 144563
doi.org/10.1016/j.mo...

#ramaneffect

Emerging Trends in Pharmaceutical and Biopharmaceutical Analysis

📣 VIRTUAL SYMPOSIUM
Emerging Trends in Pharmaceutical and Biopharmaceutical Analysis

Presented by Spectroscopy, the Coblentz Society, and the Society for Applied Spectroscopy

Day 1: Thursday, November 20, 10:00 AM EST
Day 2: Friday, November 21, 10:00 AM EST
globalmeet.webcasts.com/starthere.js...

Review: Advances in synovial fluid analysis for the diagnosis of crystal arthropathies Synovial fluid analysis remains to be a critical aspect of the diagnosis of crystal arthropathies. The gold standard, compensated polarized light microscopy (CPLM), has significant shortcomings due t...

Review: Advances in synovial fluid analysis for the diagnosis of crystal arthropathies.
Arthritis Care Res. Accepted Author Manuscript. 2025
doi.org/10.1002/acr....

#review #ramaneffect

RamanSPy: An Open-Source Python Package for Integrative Raman Spectroscopy Data Analysis Raman spectroscopy is a nondestructive and label-free chemical analysis technique, which plays a key role in the analysis and discovery cycle of various branches of science. Nonetheless, progress in R...

RamanSPy: An Open-Source Python Package for Integrative Raman Spectroscopy Data Analysis.
Anal. Chem. 2024, 96, 21, 8492–8500
doi.org/10.1021/acs....

ramanspy.readthedocs.io

#ramaneffect #openaccess

Required reading for cell biologists to get a sense of basic statistical principles!

www.nature.com/articles/s41...

Coordinating health AI to prevent defensive escalation Artificial intelligence (AI) systems that can analyse medical images, records, and claims are becoming accessible to everyone. Although these systems outperform physicians at specific tasks, such as d...

The prisoner’s dilemma in A.I. healthcare—
when rational A.I. use can lead to harmful outcomes
Our new piece @thelancet.com
@rajpurkar.bsky.social and Michael Moritz
thelancet.com/journals/lan...

Posthandling Spectral Information Enhancement for Single Cell Raman Molecular Mapping Analysis Biochemical analysis of living systems such as single cells benefits greatly from the label-free and low-invasive molecular mapping with Raman microspectroscopy. Sets of Raman spectra at different spatial points are analyzed to generate Raman molecular maps corresponding to specific chemical species. However, human error and subjective data analysis can be technical issues that limit interpretation and its validity. Here, we present an objective data analysis scheme for postprocessing large data sets of Raman spectra for molecular mapping of living cells. The process comprises three steps: (i) Denoising the spectral data set using low-rank approximation; (ii) obtaining an objective background from data points outside the target cell; (iii) subtracting the thus obtained background using Hypothetical Addition Multivariate Analysis with Numerical Differentiation (HAMAND) via an automatically determined coefficient. Through the present analysis, minor Raman peaks, as indiscernible as they are, can be identified and precisely mapped. We demonstrate a quantitative discussion of cellular components after extracting contributions only from a single target cell from a Raman mapping image where multiple cells or parts of other cells are present. This work opens an improved analysis workflow for accurate spectroscopic analysis of living cells with the advantage of identifying minor Raman peaks unambiguously.

Posthandling Spectral Information Enhancement for Single Cell Raman Molecular Mapping Analysis.
Anal. Chem. 2025
doi.org/10.1021/acs....

#ramaneffect #openaccess

Multimodal SRS imaging reveals metabolic remodeling in ovarian precancerous lesions.

In collaboration with Prof. Lingyan Shi (UCSD), we integrated spatial metabolomics into a new 3D tissue mapping workflow at single-cell resolution

More here: www.biorxiv.org/content/10.1...

Please start following @natbiomedeng.nature.com! It's an alive account now and we will start posting good content!

Johns Hopkins sophomore student Florin Selaru develops a new scheme to deconvolve colors in histological sections for digital pathology.

It greatly outperforms traditional linear color deconvolution.

Congrats Florin!

Read his paper here: www.biorxiv.org/content/10.1...

Calibration for Quantitative Chemical Analysis in IR Microscopic Imaging Infrared spectroscopy of macroscopic samples can be calibrated against reference analysis, such as lipid profiles acquired by gas chromatography, and serve as a fast, low-cost, quantitative analytical...

Calibration for Quantitative Chemical Analysis in IR Microscopic Imaging.
Anal. Chem. 2025
doi.org/10.1021/acs....
#infrared #openaccess

A point-of-care diagnostic for drug-induced liver injury using surface-enhanced Raman scattering lateral flow immunoassay - Nature Communications There is an unmet clinical need for a rapid point-of-care tests to identify patients at high-risk of developing acute liver failure following a paracetamol overdose. Here, authors assess a diagnostic test, consisting of a lateral flow immunoassay paired with a handheld Raman reader, in performance evaluation studies.

A point-of-care diagnostic for drug-induced liver injury using surface-enhanced Raman scattering lateral flow immunoassay.

Nat Commun 16, 6223 (2025).
doi.org/10.1038/s414...

#ramaneffect #liver #openaccess

Biophotothermic and Optical Spectroscopy for the Study of
Pharmaceutical and Material Formulations for Dentistry

Espectroscopia biofototérmica e óptica para o estudo de
Formulações farmacêuticas e materiais para odontologia.

Monique de Souza
www.pfi.uem.br/wp-content/u... in Portuguese

#infrared #photothermal #atrir #ramaneffect #openaccess