Journal of Experimental Medicine

NIK-driven IL-23 production by #myeloid cells is a key factor in the development of autoimmune #inflammation. New study from Nishada S. Ramphal, Ari Waisman (@ariwaisman.bsky.social) and colleagues @mainzuniversity.bsky.social: rupress.org/jem/article/...

#Neuroinflammation #Autoimmunity

Central neurons encode interleukin-1β signals and mediate stress-induced #inflammation. New study from Okito Hashimoto, Tyler D. Hepler, Kevin J. Tracey, Sangeeta S. Chavan and colleagues @northwellhealth.bsky.social: rupress.org/jem/article/...

#Neuroinflammation #Cytokines

Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology Single-cell and spatial transcriptomics of human TB lung tissues from individuals in South Africa revealed that MMP1+CXCL5+ fibroblasts and SPP1+ macrophag

Played a small part in this cool study @jem.org.

Identifies myofibroblasts as sources of tissue damaging enzymes (MMP1) in TB granuloma, probably responding to cytokine cues from nearby macrophages.

Question now is: can we target therapeutically to prevent post-TB lung damage?

#TBSky #IDSky

The cribriform plate: A dynamic central nervous system immune hub. Review from Collin J. Laaker, Zsuzsanna Fabry and colleagues: rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

📄 See a recent publication in @jem.org from Silvia Monticelli's group, "FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes": hubs.la/Q0420W4b0

“In 20+ years of research, this was one of the most constructive editorial interactions I’ve had." — Dr. Silvia Monticelli. Discover how JEM’s collaborative model puts your science first. 👉 hubs.la/Q041Rzhg0

Amyloidosis of bridging veins is a pathologic feature of #Alzheimers disease, from @leonsmyth.bsky.social, Rupal Mehta, @jonykipnis.bsky.social et al. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

Happy to be a co-author in this study and share it with you

In many #IBD patients, motility disorders persist even during remission. Kurapati et al. show that postinflammatory GI motility dysfunction arises from structural remodeling of the enteric nervous system, driven by a combination of neuronal loss & neurogenesis. rupress.org/jem/article/...

Klepper, Tana, DeRisi et al. show that patients with #autoimmune #hepatitis have a unique autoantibody signature, incl. evidence for cross-reactivity with a common #herpesvirus & antibodies targeting the antifibrotic relaxin receptor with potential to promote #fibrosis rupress.org/jem/article/...

New study from the labs of Willinger, Lambrecht, Marichal and colleagues found that #cholesterol metabolites recognized by the receptor GPR183 attract #monocytes to repopulate depleted lung #macrophage niches. rupress.org/jem/article/...

#Metabolism #MucosalImmunology #InnateImmunity #inflammation

Xin Geng, Michael Davis, Sathish Srinivasan and colleagues show that S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

Our March issue is here! rupress.org/jem/issue/22...
The cover depicts fluorescent immunohistochemistry staining of a human lung #TB granuloma: #macrophages (yellow), SPP1+ cells (green), macrophages enriched in alveolar spaces (red), and nuclei (blue). See Mbano et al. rupress.org/jem/article/...

Delve into recent JEM studies in the fields of #hematopoiesis and #myeloid lineages, incl. the role of neutrophils in myocardial & vascular injury, the characterization of intrarenal myeloid cells, a deeper understanding of the origin & function of #DendriticCells & more: rupress.org/jem/collecti...

@simoncleary.bsky.social, Longhui Qiu, Mark Looney et al. developed a new #intravital technique for imaging pulmonary lymphatics. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

Intestinal lymphatic vasculature is functionally adapted to different drainage regions and is altered by #helminth infection. From Jorden Lane, Daria Esterházy and colleagues: rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

A novel #zebrafish model from @karinayaniv.bsky.social et al. provides a powerful platform to dissect kaposiform lymphangiomatosis (KLA) pathogenesis and identify new therapeutic avenues. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

Allergic airway reactions rewired by PI3Kδ mutation. Lawrence Kane discusses new study from Golec et al. (rupress.org/jem/article/...), in Insights: rupress.org/jem/article/...

#Immunodeficiency #LymphocyteBiology

Ramphal, Waisman et al. @mainzuniversity.bsky.social reveal that NIK drives neuroantigen-specific T cell priming by regulating antigen presentation and IL-23 production, identifying NIK as a key orchestrator of #myeloid-driven CNS #autoimmunity. rupress.org/jem/article/...

#Neuroinflammation

A PI3Kd-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation. New study from Dominic P. Golec, Pamela L. Schwartzberg and colleagues @niaidnews.bsky.social: rupress.org/jem/article/...

#Immunodeficiency #LymphocyteBiology

Immune checkpoint inhibitor induced myocarditis is dependent on CD8 T cell-derived TNF and TNFR2 signaling. New study from Kathrynne A. Warrick, Chandrashekhar Pasare and colleagues @cincychildrens.bsky.social: rupress.org/jem/article-...

#CardiovascularBiology #InnateImmunity #TumorImmunology

Qing Chang, Jian-Fu Chen et al. show lymphatic vessels are present in the skull periosteum but absent in bone marrow, with channel and bone marrow heterogeneity varying by skull region and age. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

Sensory nerves respond differentially to inflammatory #cytokines, but it's unknown if this governs physiological responses via distinct central circuits. Hashimoto et al identify a circuit in which IL-1β–responsive neurons control several components of the stress response rupress.org/jem/article/...

Bauer et al. @halinlab.bsky.social reveal how the structure and cellular morphology of human dermal afferent lymphatic vessels differ from the current, primarily mouse tissue–based textbook description. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

Lymphatic Vessels in Health and Disease 2026 | Journal of Experimental Medicine | Rockefeller University Press Advertisement

See our collection of the latest discoveries in lymphatic biology: rupress.org/jem/collecti...

Are you attending the GRC meeting on #Lymphatics in Italy and interested in discussing your work with a JEM editor? Get in touch with JEM's Senior Editor Lucie Van Emmenis (@lucie-jexpmed.bsky.social) who will be there!
📩 Email Lucie: rupress.org/jem/pages/ed...

Explore the latest discoveries in lymphatic biology, incl. studies on lymphatic vessels in the skin, skull, intestine & lung, novel imaging techniques, & the role of lymphatic vessels in various pathologies. New research to accompany the upcoming GRC #Lymphatics meeting: rupress.org/jem/collecti...

Next-generation #CRISPR screens enable causal systems #immunology. New Perspective from Hao Shi and Hongbo Chi @stjuderesearch.bsky.social: rupress.org/jem/article/...

#LymphocyteBiology #TumorImmunology

Sticky memories of an activated #macrophage. Luca Frosio and Renato Ostuni @ostunilab.bsky.social @unisr.bsky.social discuss new findings by Gorin et al. (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...

#InnateImmunity #inflammation

Molecular and phenotypic blueprint of human #hematopoiesis links proliferation stress to #StemCell #aging. From Emanuele Lettera et al. @dimiccolab.bsky.social: rupress.org/jem/article/...

📘 In Hematopoiesis and #Myeloid Cells collection: rupress.org/jem/collecti...

#KSMyeloid26 #KSHemato26