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Marco Hein

@marco.heinlab.org

Systems biologist • Prof at Max Perutz Labs & MedUni Vienna • dad×2 • he/him #LoveVirology #TeamMassSpec #dataviz 📍 Vienna 🇪🇺

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Latest posts by Marco Hein @marco.heinlab.org

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Fantastic news! 🙌 The Perutz is excited to welcome Danny Nedialkova as a new group leader starting this April! 🎉 She will strengthen the institute's research on the fundamental mechanisms that shape cellular physiology and disease ➡️ www.maxperutzlabs.ac.at/research/res...

02.03.2026 14:27 👍 58 🔁 11 💬 1 📌 4

Die Gesellschaft für Virologie begrüßt und unterstützt die Corona-Enquetekommissionen in den verschiedenen Parlamenten. Allerdings nehmen wir mit großer Sorge zur Kenntnis, dass darin auch wissenschaftlich nicht tragbare Behauptungen aufgestellt werden, wie kürzlich in der Kommission des … (1/2)

23.12.2025 07:25 👍 52 🔁 21 💬 1 📌 4
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#Grippe-Welle in Österreich
Zunahme der Influenzafälle - im Sentinelsystem überwiegen Nachweise von Influenza A Subtyp H3N2 und H1N1 (3:1)

Weiterhin Aktivität von
#SARS-CoV2 #Parainfluenza #saisonaleCoronaviren #Rhinoviren, sporadische RSV-Infektionen

#ZentrumVirologie #MedUniWien

12.12.2025 20:58 👍 80 🔁 26 💬 4 📌 1
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🎉 Congratulations to Max Kellner, former PhD student in the Penninger Lab, who was presented with the ÖGBMT Life Sciences PhD Award Austria. The award recognizes Kellner’s PhD research on how dangerous viruses emerge from natural reservoirs like bats. More: https://imba.science/3KiRYSN

25.09.2025 11:00 👍 16 🔁 4 💬 0 📌 2
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Our Autumn call is now open with over 20+ fully funded positions in various disciplines in the life sciences. Interested? Check out our vacancies in computational biology, genomes & evolution and the exciting projects being offered here: ow.ly/aBgQ50WY1S2

17.09.2025 12:00 👍 1 🔁 1 💬 1 📌 0

I couldn’t be prouder of my team! Kavya and Sebastian both won DOC fellowships from the Austrian Academy of Sciences!
Congratulations to all awardees!

15.07.2025 19:34 👍 21 🔁 2 💬 1 📌 0
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We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/

15.07.2025 08:11 👍 115 🔁 59 💬 3 📌 7

Join us at the Perutz, part of the Vienna Biocenter!
Opening for a full professorship in Molecular Mechanisms of Disease 👇🏻
@maxperutzlabs.bsky.social @viennabiocenter.bsky.social
@univie.ac.at

08.07.2025 12:25 👍 13 🔁 9 💬 0 📌 1
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Full Professorship in Molecular Mechanisms of Disease - Vienna BioCenter, Austria job with Max Perutz Labs, University of Vienna | 12841053 Join theMax Perutz Labs as Full Professor to unravel disease mechanisms—from metabolism and stress to RNA regulation, epigenetics, and immunity.

Exciting and rare opportunity to join the @maxperutzlabs.bsky.social and the @viennabiocenter.bsky.social as a Full Professor!
www.nature.com/naturecareer...

02.07.2025 07:18 👍 36 🔁 29 💬 0 📌 2
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Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!

12.06.2025 20:31 👍 69 🔁 52 💬 2 📌 6

Congratulations Shira & team!

13.06.2025 10:12 👍 1 🔁 0 💬 1 📌 0
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If you love #viruses, #ribosomes, and genomic #darkmatter, this thread is for you!! 💫
We're excited to share our new publication developing Massively Parallel Ribosome Profiling (MPRP), which uncovered ~4,000 hidden proteins in ~700 viral genomes. www.science.org/doi/10.1126/...

12.06.2025 21:19 👍 46 🔁 16 💬 3 📌 3
[Person with ponytail wearing lab coat hands balloon to another person in front of a springboard, a magnet hanging from above, and then a target] PERSON WITH PONYTAIL to Person 2: Rub this balloon against your head, then go jump past that magnet toward the target on the wall. [caption] Before the bathroom scale was invented, the only way to weigh people was mass spectrometry.

[Person with ponytail wearing lab coat hands balloon to another person in front of a springboard, a magnet hanging from above, and then a target] PERSON WITH PONYTAIL to Person 2: Rub this balloon against your head, then go jump past that magnet toward the target on the wall. [caption] Before the bathroom scale was invented, the only way to weigh people was mass spectrometry.

Mass Spec

xkcd.com/3094/

29.05.2025 19:26 👍 3905 🔁 469 💬 28 📌 24
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Bat organoids reveal antiviral responses at epithelial surfaces - Nature Immunology Kellner et al. develop respiratory and intestinal organoids from Rousettus aegyptiacus to show elevated basal expression of interferon-ε (IFNε) and IFN-stimulated genes, along with robust, self-amplifying type III IFN responses that drive antiviral defense against zoonotic RNA viruses.

Hi 🦋 I’m thrilled to share that our #bat #organoid work has found a publishing home in Nature Immunology!

These models provided unprecedented insight into antiviral immunity at epithelial surfaces of the Egyptian fruit bat 🦇 — a natural reservoir of Marburg virus 🦠

www.nature.com/articles/s41...

21.05.2025 19:14 👍 46 🔁 11 💬 1 📌 3
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Juliane Winkler mit dem Johann Wilhelm Ritter von Mannagetta-Preis ausgezeichnet Mehr über die Studie zur Entstehung von Metastasen!

Innovative Forschung zur Entstehung & Kontrolle von #Metastasen ⤵️

Wir gratulieren @jwinkler.bsky.social von der #MedUniWien zur Auszeichnung der @oeaw.bsky.social mit dem Johann Wilhelm Ritter von Mannagetta-Preis!

06.05.2025 06:41 👍 11 🔁 4 💬 0 📌 1
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🌟 Exciting #PhD Opportunity! Join my lab in beautiful #Vienna. We are studying tumor-immune interactions in #metastasis using #singlecell and #spatial omics! ⏰ Apply by 04/25 bit.ly/3l7WMhs more infos 👉 winklerlab.org

07.04.2025 11:24 👍 24 🔁 16 💬 0 📌 1
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Search for LIFE SCIENCE and AI/ML Starting Principal Investigators (m/f/d) at AITHYRA, Vienna If you are an ambitious early-career scientist ready to propel your research to new heights, we invite you to be part of AITHYRA’s founding generation of Principal Investigators. Together, we will sha...

Aithyra is hiring! We are looking for multiple starting PIs in life sciences and AI/ML. We offer highly competitive packages and salaries among the highest in Europe.

www.oeaw.ac.at/aithyra/news...

17.03.2025 20:07 👍 39 🔁 12 💬 2 📌 2
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IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.

28.03.2025 11:15 👍 67 🔁 75 💬 1 📌 4
Screenshot of the “aims and scope” page of the fictitious journal “Nature Cell Science” [April fools]

Screenshot of the “aims and scope” page of the fictitious journal “Nature Cell Science” [April fools]

Dear @nature.com publishing group:
We swallowed your $12k article processing charge, but the name of your new journal is too much…

01.04.2025 14:24 👍 29 🔁 0 💬 2 📌 0
Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇

17.03.2025 11:56 👍 546 🔁 259 💬 12 📌 33

Agarose/sepharose doesn't work as affinity resin base for large organelle cargo, only smooth magnetic particles do, limiting the selection of commercial reagents. Nanobodies would have been nice because they generate less background during on-bead digest. Ultimately we went back to square 1: HA.

12.03.2025 12:37 👍 2 🔁 0 💬 0 📌 0

Earlier papers that IPed organelles had already used HA, so this was our starting point. We tried a panel of other tags, hoping to find a better one for which commercial nanobody-conjugated magnetic affinity beads were available. TL;DR: we didn't find a better one.

12.03.2025 12:37 👍 2 🔁 0 💬 1 📌 0
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Our Spring call is now open with over 25+ fully funded positions in various disciplines in the life sciences. Interested? Check out our vacancies and the exciting projects being offered here: www.vbcphd.at
Application Deadline: 15 April 2025

06.03.2025 16:19 👍 10 🔁 4 💬 1 📌 0
A set of three wall shelf sets, in the form of boxplots

A set of three wall shelf sets, in the form of boxplots

📊Looking to re-decorate your #dataviz office?
You need Boxplot Shelves! |----[ ]--|

05.03.2025 03:13 👍 233 🔁 43 💬 5 📌 5
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Heading to my SF local #standupforscience rally tomorrow along with many UCSF colleagues and friends. Making signs this afternoon at departmental happy hour hosted by @elphegenoralab.bsky.social - we need inspiration!

06.03.2025 20:00 👍 13 🔁 3 💬 0 📌 0
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A high-res approach to localise thousands of proteins within a cell

📷: Marco Hein, Duo Peng, Verina Todorova, Frank McCarthy, Kibeom Kim, Chad Liu et al @czbiohub.bsky.social in @cellpress.bsky.social
➡️: bpod.org.uk/archive/2025/2/22 with
@rooph.bsky.social

24.02.2025 09:02 👍 5 🔁 3 💬 0 📌 0

Welcome to the VBC!

06.02.2025 15:00 👍 1 🔁 0 💬 1 📌 0
Announcement poster for Marco Hein's seminar 'How to perform and analyze single-cell sequencing"

Announcement poster for Marco Hein's seminar 'How to perform and analyze single-cell sequencing"

Join me tomorrow 4 Feb at 14:00 CET for an educational seminar about single-cell transcriptomics in virology:
Register here: us06web.zoom.us/meeting/regi...

This is seminar 1 of the new season of @gesvirologie.bsky.social's ACHIEVE Academy's 'How-To' seminars, targeted at PhD and Master's students.

03.02.2025 08:50 👍 8 🔁 4 💬 0 📌 1
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Congratulations to Max Kellner (Penninger Group) on the completion of his PhD! Max presented his work on molecular virus diagnostics for resource-limited settings and, separately, on modeling host-virus interactions in natural reservoir species using bat organoids.

31.01.2025 11:25 👍 10 🔁 3 💬 2 📌 0
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📑 New study out now! The Kovarik lab uncovers a novel mechanism for eliminating pro-inflammatory pre-mRNAs in the nucleus - preventing the overproduction of cytokines published in Molecular Cell ➡️ tinyurl.com/m8p87k6k

@univie.ac.at

30.01.2025 09:01 👍 24 🔁 4 💬 2 📌 1