Christoph Budjan

A confocal image of a 3D human Trunk-like Structure (hTLS) made from pluripotent stem cells, showing a neural tube (cyan) and segmented somites (magenta).

We're recruiting a #devbio Postdoctoral Fellow to explore the hTLS system! If you know any fab PhD students finishing, or candidates wanting to get their hands on #SCBEM embryo models, do get them to apply! 🌟https://www.crick.ac.uk/careers-study/vacancies/2026-02-03-postdoctoral-fellow-moris-lab

Needless to highlight what I think about this. As underappreciated as it is important #Wntch the way cell populations coordinate and balance cell fate decisions

Congrats! Beautiful work.

#N2B27 is an acronym that creates a lot of trouble in labs growing #gastruloids because of variability. Building on earlier work from A. Smith’s lab, my colleagues decided to address the root of the issue shorturl.at/QM4C6
and see their views on the work shorturl.at/dYB9X

🌍Open call: Junior Group Leader positions!

Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.

Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...

Neil Shubin (1) - Denis Duboule (2025-2026) YouTube video by Sciences de la vie - Collège de France

One of, so far 3 lectures being delivered @college-de-france.fr by @neilshubin.bsky.social
on our fish origins.
www.youtube.com/watch?v=0B6y...
Wonderful flow, educational, inspirational.
How we learn @ our ancestry. The origin of #walking. How we got our skeleton #MustWatch

Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...

Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social

We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇

www.biorxiv.org/content/10.1...

MRC DiMeN Doctoral Training Partnership: How does Wnt and Notch (Wntch) signalling coordinate cell fate assignment during gastrulation? at University of Liverpool on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: How does Wnt and Notch (Wntch) signalling coordinate cell fate assignment during gastrulation? at University of Liverpool, listed on FindAPhD.com

Like Wnt signalling? How about Notch? How about both together (Wntch!)... in gastruloids? Come and and apply for a PhD studentship with us in Liverpool! Applications open 30th October! tinyurl.com/3bpx3y2b

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Landscapes and embryos : A film from A. Martinez Arias YouTube video by Cambridge University

Organizing time past, remembered this summary of many thoughts that I continue to pursue
And nowhere rings more true that ‘the detail of pattern is the movement’ than in the actions of cells as they build #embryos
www.youtube.com/watch?v=bbQV...
#CellsRUs #MasterBuilder

Today is the 100th anniversary of the birth of Robert Edwards, #IVF pioneer and someone who, unknowingly, bridged #DevBio #Gynecology and Endocrinology in a highly successful manner.

Discovery of A Small Molecule non-IMiD Degrader of ZBTB7A for the Treatment of β-hemoglobinopathies Sickle cell disease and β-thalassemia, two major β-hemoglobinopathies, pose significant clinical challenges globally. Current treatments often face limitations in efficacy and tolerability. The transc...

Thrilled to share new work from Jun Liu & collaborators (with minor contributions from our lab), now on bioRxiv: SH6, a small molecule that boosts fetal hemoglobin, offering a new path for sickle cell + β-thalassemia therapies.
👉 www.biorxiv.org/content/10.1...
#SickleCellDisease #Thalassemia

We are searching for an enthusiastic scientist to join our team and establish annual killifish as a model system for early developmental biology and biophysics! @embl.org @embldbunit.bsky.social

Apply here:
embl.wd103.myworkdayjobs.com/EMBL/job/Hei...

Please re-post 🙏

It’s always a bit awkward to write about personal experiences. I tried to touch on what Pride means to me and ended up reflecting on heteronormativity, passing, and allyship. Thank you @slefkopoulos.bsky.social for the great opportunity! @ucph.bsky.social
#LGBTQIA+ #PRIDE #Diversity

Two new preprints from the @arjunraj.bsky.social‬ on #gastruloids. Both excellent. Exploring the relationship between macroscopic reproducibility v microscopic heterogeneity. Stunning experiments and much to think about
biorxiv.org/content/earl...
biorxiv.org/content/earl...

Human embryo research: how to move towards a 28-day limit The decades-old limit on how long human embryos can be grown in culture is under debate. A new road map outlines how to extend the length of culture responsibly.

A new call to revise the limit to culture human embryos, currently not allowed beyond 14 days (start of gastrulation) to 28 days www.nature.com/articles/d41....
There is no new argument here to add to earlier calls but, as often in this argument, certain caveats are glossed over….. . 🧵

Experimental embryology postdoc available in my lab at the @biology.ox.ac.uk @ox.ac.uk working on the evolution of vertebral counts. Reach out if you’re passionate about EvoDevo, enjoy lab work and microscopy and are into or could get into cichlid fishes. Deadline on the 16th June. Please share!

A few reflections on the Barcelona @PRBB #gastruloid meeting
🧵

Finally, thank you to Andre, Joshi and Ulla for organizing. Looking forward to the next one!

One important takeaway for me was a push especially in human gastruloids to make this system more reproducible and data comparable across labs by connecting and sharing detailed protocols, reagent info etc. Looking forward to more interactions in the future.

I had an amazing time attending the gastruloid meeting in BCN! It felt great connecting with other people in the field and seeing many familiar faces. Lots of exciting science with #gastruloids being used to address many open questions from basic to translational.

There's increasing evidence that in organoid/embryoids conditions of cells at start of experiments is crucial/ determines outcome. Much to be learnt still. Taking advantage of mouse #gastruloids, two groups explore this here. Important work to calibrate the field www.biorxiv.org/content/10.1...

Are you are eager to deepen your knowledge on #organoids and explore research from both academia and industry?

Join #BaCell3D 2025! Beyond an excellent scientific program, you will have the chance to benefit from tailored workshops for scientists, engaging poster sessions and networking events!

Great opportunity to work on super exciting projects using gastruloids with a brilliant, supportive mentor!

Great opportunity for Boston folks interested in learning image analysis and automation using ImageJ/Fiji

Intriguing study showing decoupling btw morphogenesis and patterning in gastruloids. An observation that many people in the field have known but great to see this tackled in a systematic and quantitative manner. See also related papers by @amartinezarias.bsky.social and @viktri08.bsky.social labs

📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

Beautiful evolution of human gastruloids to human TLS to study co-development of neural tube and somites! #gastruloids #TLS #SCEM

Comprehensive review on extraembryonic tissues during mammalian development by @srinivas-lab.bsky.social - looks like required reading for everyone interested in mammalian development, including #SCEM folks! Congrats and thanks to @shifaant.bsky.social & @cwhanna.bsky.social