iMeta Science

Inhibition of ferroptosis by microbiota‐derived lithocholic acid underlies the intestinal radioprotection of a host defensin‐derived oligopeptide AT9(C/G), an oligopeptide derived from human defensin 5, enriches Bifidobacterium pseudolongum and increases lithocholic acid (LCA) levels in the intestine. Reduced levels of LCA link to increased se...

🤔A microbiota-targeted peptide shows promise for protecting the intestine from radiation injury.
Inhibition of ferroptosis by microbiota-derived lithocholic acid underlies the intestinal radioprotection of a host defensin-derived oligopeptide.
onlinelibrary.wiley.com/doi/10.1002/...

Oral proton‐reprogrammed nanomedicine to break the inflammatory bowel disease‐Clostridium difficile infection vicious cycle Research on the mechanism of OPR restoring intestinal epithelial cell (IEC) structure and function in inflammatory bowel disease (IBD) treatment. (A) Schematic diagram of OPR structure and the rate o...

Metabolic reprogramming of intestinal epithelial cells offers a new strategy for IBD–CDI treatment
💊 An oral proton-reprogrammed nanomedicine to break the inflammatory bowel disease-Clostridium difficile infection vicious cycle
@WileyHealth onlinelibrary.wiley.com/doi/10.1002/...

Curcuminoids amplify host innate antiviral immunity via the CRYAB‐RBM26 axis in viral infection DMC/CUR antagonize viral hijacking of host nucleic acid resources and finely regulate the induction and effector phases of the type I interferon (IFN-I) pathway through the CRYAB-RBM26 axis. This mol....

🌿Curcuminoids amplify host innate antiviral immunity via the CRYAB-RBM26 axis in viral infection
#VirusDefense #Curcuminoids #ScientificBreakthrough
onlinelibrary.wiley.com/doi/10.1002/...

Chromatin unwinding state for in situ identification and lineage tracing of circulating tumor cells The detection of circulating tumor cells (CTCs) through liquid biopsy offers a non-invasive approach for accurately monitoring cancer dissemination and evaluating therapeutic efficiency. However, the...

🚀 New breakthrough in cancer detection!
Chromatin unwinding state for in situ identification and lineage tracing of circulating tumor cells
#CancerResearch #LiquidBiopsy #PanCTC #CancerDetection #AIinMedicine
onlinelibrary.wiley.com/doi/10.1002/...

A bioactive ginsenoside alleviates hepatocellular ferroptosis induced by oxidized phospholipid accumulation in nonalcoholic steatohepatitis Schematic representation showing that 20 (S)-Rg3 improves mouse NASH. 20(S)-Rg3 reduces OxPLs levels and ameliorates ferroptosis in the liver of NASH mice. Mechanistically, 20(S)-Rg3 activates SPOP. ...

👏 Targeting ferroptosis in NASH

🧐 A bioactive ginsenoside alleviates hepatocellular ferroptosis induced by oxidized phospholipid accumulation in nonalcoholic steatohepatitise.
#NASH #Ferroptosis #LiverDisease #Metabolism
onlinelibrary.wiley.com/doi/10.1002/...

BIOME cohort: Multi‐system microbiome dynamics and clinical outcomes in massive burn injury patients Massive burn injuries (MBIs) are associated with high mortality and disability rates, primarily due to microbial-driven sepsis from extensive skin barrier loss and subsequent scar formation. This mak....

BIOME cohort: Multi-system microbiome dynamics and clinical outcomes in massive burn injury patients
🔥 A cohort to map microbiome dysbiosis after massive burn injury.
onlinelibrary.wiley.com/doi/10.1002/...

EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research
onlinelibrary.wiley.com/doi/10.1002/...

Microbial influences on immune modulation and colorectal cancer progression through combined transcriptomic and microbiomic analysis. onlinelibrary.wiley.com/doi/10.1002/...

The role of the gut microbiome in the regulation of high‐altitude adaptation This study is the first to elucidate mechanisms of high-altitude adaptation from the perspective of the rumen ecosystem by using indigenous yaks and Holstein cows that have lived at high altitude sin...

⛰️ Gut microbiome–host metabolism supports high-altitude adaptation in ruminants.
The role of the gut microbiome in the regulation of high-altitude adaptation.
onlinelibrary.wiley.com/doi/10.1002/...

Distinct sinonasal microbiota define clinical subtypes of CRSwNP.
💡 Microbiome-based stratification may support personalized therapy for CRSwNP. onlinelibrary.wiley.com/doi/10.1002/...

Resistome flow in global landfill systems Global landfill systems represent key hubs of resistome, serving as dynamic reservoirs and amplifiers through plasmid-driven gene mobility. Waste flows and environmental pathways sustain the transbou...

🗑️ Global landfill systems are major hotspots for antibiotic resistance genes!
⚙️ Metagenomic analyses reveal highly mobile, plasmid-enriched ARGs—dominated by multidrug resistance—and extensive resistome flows within and beyond landfills.
onlinelibrary.wiley.com/doi/10.1002/...

Diversity, transfer potential, and transcriptional activity of virus‐carried antibiotic resistance genes in global estuaries Estuaries are vital hotspots for antibiotic resistance genes (ARGs) due to substantial antibiotic pollution. Although viruses have been proposed as key reservoirs and important disseminators of ARGs ...

🌊A global estuarine virome reveals active virus-carried antibiotic resistance genes.
onlinelibrary.wiley.com/doi/10.1002/...

Fast bootstrap and reliable readout using hidden references for DNA data storage This study provides a bootstrap readout framework for DNA data storage based on multiple-fold hidden references. We employ a multi-stage alignment and error correction strategy, transforming the de n...

A fast, robust readout framework advances large-fragment DNA data storage. onlinelibrary.wiley.com/doi/10.1002/...

MOMMY study profile: An integrative early‐life multi‐omics cohort in China MOMMY cohort (The MOther-infant Microbiota transmission and its link to long terM health of babY) is a large, prospective birth cohort uniquely designed to investigate maternal-paternal-infant microb...

👶 MOMMY study profile: a large prospective birth cohort uncovering early-life microbiome transmission in China.
💡 A unique resource to advance global understanding of early-life microbiome–health trajectories. onlinelibrary.wiley.com/doi/10.1002/...

Tidyplots empowers life scientists with easy code‐based data visualization
onlinelibrary.wiley.com/doi/10.1002/...

Gut microbes help black soldier fly larvae cope with excess uric acid.
⚙️ A uric acid–degrading Enterococcus faecalis strain restores larval growth and improves bioconversion efficiency by catabolizing dietary UA. onlinelibrary.wiley.com/doi/10.1002/...

CAT‐BLAST: Engineered bacteria for robust targeting and elimination of cancer‐associated fibroblasts Cancer-associated fibroblasts (CAFs) construct a protective stromal barrier that promotes tumor growth and resistance to therapy. To dismantle this, we developed CAT-BLAST, an engineered bacterial pl...

🎯 Engineered bacteria target cancer-associated fibroblasts to break tumor protection!
⚙️ CAT-BLAST, a FAP-targeting E. coli platform, selectively eliminates Cancer-associated fibroblasts and induces tumor cell apoptosis via ClyA secretion.
onlinelibrary.wiley.com/doi/10.1002/...

Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction The pervasiveness of microplastic pollution poses a growing health risk, yet its long-term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanopartic...

🧪 Nanoplastic exposure disrupts bile acid metabolism and gut microbiota, driving systemic metabolic collapse.
onlinelibrary.wiley.com/doi/10.1002/...

Antioxidants promote metabolic remodeling in cattle rumen epithelium revealed by single‐cell resolution Single-cell and transcriptomics from 1.79 million cells identify the forestomach epithelium as the dominant site of antioxidant activity and oxidative phosphorylation (OXPHOS) in the bovine gastroint...

Antioxidants promote metabolic remodeling in cattle rumen epithelium revealed by single‐cell resolution 🐄https://onlinelibrary.wiley.com/doi/10.1002/imt2.70100

Efficacy and biomarker analysis of neoadjuvant disitamab vedotin (RC48‐ADC) combined immunotherapy in patients with muscle‐invasive bladder cancer
onlinelibrary.wiley.com/doi/10.1002/...

An Interpretable Machine Learning Model for Predicting 5‐Year Survival in Breast Cancer Based on Integration of Proteomics and Clinical Data This study first introduced Kolmogorov–Arnold Network (KAN) into the deep learning model for the integration of clinical and proteomics data in predicting 5-year survival in breast cancer. The optima...

💡 An Interpretable Machine Learning Model for Predicting 5-Year Survival in Breast Cancer Based on Integration of Proteomics and Clinical Data! onlinelibrary.wiley.com/doi/10.1002/...

How does time‐restricted feeding mitigate Alzheimer's disease‐associated cognitive impairments? The role of the B. pseudolongum‐propionic acid‐FFAR3 axis. onlinelibrary.wiley.com/doi/10.1002/...

Dynamics and Regulation of Maternal–Fetal Interface Macrophages: From Immune Tolerance to Pregnancy Outcomes The maternal–fetal interface demands tolerance alongside antimicrobial defense. Plastic macrophages orchestrate inflammation resolution, tissue remodeling, and angiogenesis in normal gestation; compl...

Dynamics and Regulation of Maternal–Fetal Interface Macrophages: From Immune Tolerance to Pregnancy Outcomes
🧐How macrophage signaling transforms maternal-fetal health and therapeutic discovery？
onlinelibrary.wiley.com/doi/10.1002/...

Network Perturbation Analysis Identifies Three Molecular Subtypes With Distinct Clinical Outcomes and Therapeutic Vulnerabilities in Endometrial Cancer We performed network perturbation analysis on transcriptomic data from endometrial cancer patients across multiple cohorts and identified three molecular subtypes with distinct clinical outcomes. The...

Network perturbation analysis identifies new molecular subtypes of endometrial cancer
💫Three distinct subtypes show different clinical outcomes.
onlinelibrary.wiley.com/doi/10.1002/...

Host‐driven hepatic conversion of gut microbiota‐derived putrescine to spermidine mediates mannose's protective effects against hepatic steatosis in zebrafish Evidence for liver metabolism of gut-derived microbial compounds into beneficial secondary metabolites has been lacking. Here, we demonstrate that Cetobacterium somerae (C. somerae), enriched by mann....

⚡️Gut microbes and liver metabolism collaborate to fight fatty liver!
⚙️ Cetobacterium somerae converts arginine to putrescine, which the liver transforms into spermidine to reduce hepatic lipid accumulation.
onlinelibrary.wiley.com/doi/10.1002/...

Microbiota‐gut‐brain axis multi‐organ chip construction and applications in drug evaluation Microbiota-gut-brain axis multiorgan chip and its applications in drug evaluation. The chip includes essential biological components such as gut microbiota, gut barrier, blood-brain barrier (BBB), an...

💡 Microbiota-Gut-Brain Axis Multi-Organ Chip Construction and Applications in Drug Evaluation
onlinelibrary.wiley.com/doi/10.1002/...

Wuda Granule Improves the Gastrointestinal Motility via Gut‐Brain Axis in Beagle Dogs Stress sensors were implanted in the gastric body, sinus, duodenum, jejunum, and colon of beagle dogs to record gastrointestinal motility. Gastrointestinal contractile motility was assessed before an...

Wuda Granule Improves the Gastrointestinal Motility via Gut-Brain Axis in Beagle Dogs!
⚙️ Central Wuda Granule drives whole-gut motility.
#GutBrainAxis #TraditionalMedicine #Neurogastroenterology onlinelibrary.wiley.com/doi/10.1002/...

Potassium Sorbate Triggers Kidney Injury via Dysregulated Intercellular Communication: A Study Combining Network Toxicology, Machine Learning, Molecular Docking, and Single‐Cell RNA Sequencing Amyloid precursor protein (APP)-mediated endothelial-immune cell crosstalk is a novel mechanism for potassium sorbate-induced renal injury. Multi-omics integration (network toxicology, machine learni....

Integrated multi-omics reveals how potassium sorbate may trigger acute kidney injury.
⚙️ Network toxicology, machine learning & single-cell analysis identify APP as a central hub driving oxidative stress, inflammation & endothelial–immune crosstalk.
onlinelibrary.wiley.com/doi/10.1002/...

MicrobTiSDA: A flexible R package for inferring interspecies interactions and abundance dynamics in microbiome time‐series data MicrobTiSDA is a user-friendly and flexible R package specifically designed for longitudinal microbiome data analysis. By integrating process-oriented functional modules—including data input, data pr...

⚡️Using MicrobTiSDA to infer interspecies interactions from microbiome time-series data.
🔎A tool for analyzing the dynamic patterns of microbial abundance over time.
The complete analysis process from data preprocessing to result visualization. onlinelibrary.wiley.com/doi/10.1002/...

A vast stem‐progenitor cell pool, richly vascular system, and hybrid ossification drive the daily centimeter‐scale elongation of bony antlers Bone growth and regeneration remain major clinical challenges. Deer antlers, the fastest-growing mammalian bone, regenerate via endochondral ossification and elongate up to 2 cm per day, far surpassi....

🦌🧬 Single-cell multi-omics reveals how deer antlers achieve centimeter-scale daily bone growth.
#SingleCell #BoneRegeneration #MultiOmics #DeerAntler
onlinelibrary.wiley.com/doi/10.1002/...