@labwaggoner
Focused on innate immune mechanisms governing pathogenesis of disease and on NK-cell based therapies for disease. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
High-dose influenza vaccine augments serological and cellular immunity of older people with HIV @insight.jci.org
insight.jci.org/articles/vie... @univmiami.bsky.social
Genetically altered chimeric antigen receptor astrocytes targeting amyloid-Ξ² reduce a cardinal pathological feature of Alzheimerβs disease @science.org @washumedicine.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Self-amplifying RNA improves heart function after myocardial infarction in mice and pigs @science.org @columbiauniversity.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
CRTAM as a T cell checkpoint of immune-related adverse events after checkpoint blockade
www.nature.com/articles/s43...
@natcancer.nature.com
Tissue-specific clonal selection and differentiation of CD4βΊ T cells during infection @natimmunol.nature.com @rockefeller.edu @biohub.org @danmucida.bsky.social @rohamparsa.bsky.social
www.nature.com/articles/s41...
High conservation of IgΒ΅ BCR glycosylation across B cell subsets albeit limited contribution to BCR expression and function, suggesting BCR glycans may have evolved to support IgM antibody functions @natcomms.nature.com
www.nature.com/articles/s41...
Review @cellcellpress.bsky.social
Somatic genomics as a discovery engine for biomedicine
www.cell.com/cell/fulltex...
Harnessing skull bone marrow immune cells to deliver drug-loaded nanoparticles to injured brain regions improves outcomes and reveals a feasible translational strategy for targeted CNS therapy @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
CLIM-TIME, a spatially resolved in vivo CRISPR screening platform linking loss of tumor suppressor genes to distinct metastatic immune architectures and divergent responses to immunotherapy @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and inhibitory CD300 family members @cp-cellreports.bsky.social www.cell.com/cell-reports...
Potentiating dendritic cell immunotherapy by interrupting the Semaphorin 4D-induced immune-suppressive barrier @cp-cellreports.bsky.social @moffittnews.bsky.social
www.cell.com/cell-reports...
Genetically engineered eye-colonizing microbes that deliver the anti-inflammatory cytokine IL-10 enhance corneal tissue repair @cp-cellreports.bsky.social
www.cell.com/cell-reports...
Influenza A virus polymerase co-opts distinct sets of host proteins for RNA transcription or replication
www.cell.com/cell-chemica... @imperialcollegeldn.bsky.social
Activation of vascular STING signaling restores NK cell infiltration and killing of neuroendocrine small cell lung cancer @cp-cancercell.bsky.social @danafarber.bsky.social
www.cell.com/cancer-cell/...
Efficient amyloid-Ξ² degradation in Alzheimerβs disease using SPYTACs @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
Genetically encoded fluorescent reporters to visualize Ξ±-synuclein pathology in live brain @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
Hypothalamic paraventricular nucleus clock is a pharmacological node linking circadian amplitude to organismal aging @cellcellpress.bsky.social
www.cell.com/cell/fulltex... π¨π³
Hypothalamic paraventricular nucleus clock is a pharmacological node linking circadian amplitude to organismal aging @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
A paper at some point seemed that it would be left in a lab book and was worked on through a pandemic. Thanks to @dianaematei.bsky.social for persevering with this one. Please check it out π
www.cell.com/iscience/ful...
Genome-wide cfDNA fragmentomes are altered in liver disease and other morbidities and enable noninvasive detection of liver fibrosis and cirrhosis
www.science.org/doi/10.1126/...
Armoring CAR T cells with the ability to secrete VEGF-neutralizing single-chain variable fragments enhances potency and control of tumors in vivo
www.science.org/doi/10.1126/...
The HDAC inhibitor panobinostat is effective against aggressive meningiomas, and resistance is mediated through a targetable HDAC8-TGFΞ²-EMT axis
www.science.org/doi/10.1126/...
Vaccinating with a stabilized H5 hemagglutinin increases the proportion of humoral responses against neutralizing receptor binding site epitopes
www.science.org/doi/10.1126/...
Modulating alternative splicing of MECP2 is a potential therapeutic strategy for Rett syndrome @bcmhouston.bsky.social
www.science.org/doi/10.1126/...
Persistent parasites may be key to lasting immunity because without them, memory CD4+ T cells fade and protection is lost
www.science.org/doi/10.1126/...
Sympathetic nerves play an important role in autoimmune skin diseases through the norepinephrineβadrenergic receptor axis
www.science.org/doi/10.1126/...
In lung cancer, airway macrophages are modulated by an unconventional VΞ³1 Ξ³Ξ΄ T cell subset
www.science.org/doi/10.1126/...
GEMINI, an in cellulo recording platform that leverages a computationally designed protein assembly as an intracellular memory device to record the history of individual cells @nature.com @dingchanglin.bsky.social
www.nature.com/articles/s41...
Long-term efficacy and safety of the single-dose tetravalent Butantan dengue vaccine
www.nature.com/articles/s41... @naturemedicine.bsky.social
Lytic IFNΞ³ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing
www.nature.com/articles/s41...