Waggoner Lab

The lack of media coverage about the bombing of the girls elementary schools is shocking.

Immunodominant epitopes from seed storage proteins are a target of intestinal regulatory T cells that modulate immune challenge to food @sciimmunology.bsky.social
www.science.org/doi/10.1126/... @sattelylab.bsky.social @stanforduniversity.bsky.social

c-Jun overexpression fails to prevent CAR T cell exhaustion in tumors, but PD-L1 blockade restores c-Jun levels and CAR T cell activity @sciimmunology.bsky.social
www.science.org/doi/10.1126/... @fredhutch.org

Review @natrevimmunol.nature.com @drmistyjenkins.bsky.social @wehi-research.bsky.social
Progress in the development of cytokine armoured CAR T cells
www.nature.com/articles/s41...

Critical role for ANKIB1-generated K11-linked ubiquitination in the immune response activated by cGAS–STING, TLR3 and TLR4
www.nature.com/articles/s41...
@natcellbio.nature.com @walczaklab.bsky.social

Benefit of IAP (inhibitor of apoptosis) antagonism with checkpoint blockade critically depends on coordinated necroptosis in both tumour and stromal cells
www.nature.com/articles/s41...
@natcomms.nature.com @pmeier.bsky.social @ttenev.bsky.social

The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging - Nature Aging The glycolytic metabolite phosphoenolpyruvate (PEP) is identified as a protective factor during aging. Acting as an endogenous inhibitor of cGAS−STING, PEP reduces inflammation and improves cognition ...

Phosphoenolpyruvate (PEP), a metabolite in glycolysis, directly inhibiting cyclic GMP–AMP synthase (cGAS). Biphasic fluctuation and eventual collapse of PEP levels during aging driving onset of inflammaging @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...

Spatial transcriptomics maps host–gut microbiome biogeography at high resolution
www.nature.com/articles/s41...
@natmicrobiol.nature.com @dwmckellar.bsky.social @ntekasi.bsky.social

Plasmalogen metabolism shapes germinal center immunity @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.6...

@biorxivpreprint.bsky.social Macrophage-derived extracellular vesicles promote T cell-dependent inflammatory pain resolution
www.biorxiv.org/content/10.6...

@biorxivpreprint.bsky.social Using peptide-exchange systems to interrogate peptide-specific KIR binding to HLA-I
www.biorxiv.org/content/10.6... @mjwsim.bsky.social @ox.ac.uk

T-bet Fate Mapping Reveals Gestational Stage-Specific Transcriptional Adaptation of Decidual NK Cells @uwmadison.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...

CRISPR deletion of NOXA but not BIM enhances the post-cryopreservation cytotoxicity, superior metabolic fitness, and extended proliferative capacityof NK cells for cancer therapies @moltherapy.bsky.social
www.sciencedirect.com/science/arti...

High-dose influenza vaccine augments serological and cellular immunity of older people with HIV @insight.jci.org
insight.jci.org/articles/vie... @univmiami.bsky.social

Genetically altered chimeric antigen receptor astrocytes targeting amyloid-β reduce a cardinal pathological feature of Alzheimer’s disease @science.org @washumedicine.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

Self-amplifying RNA improves heart function after myocardial infarction in mice and pigs @science.org @columbiauniversity.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

CRTAM inhibition mitigates toxicity of immune checkpoint inhibitors without antitumor efficacy trade-off - Nature Cancer Dong and colleagues report that blockade of T cell-expressed cytotoxic and regulatory T cell molecule results in selective mitigation of immune-related toxicities without affecting antitumor efficacy ...

CRTAM as a T cell checkpoint of immune-related adverse events after checkpoint blockade
www.nature.com/articles/s43...
@natcancer.nature.com

Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection @natimmunol.nature.com @rockefeller.edu @biohub.org @danmucida.bsky.social @rohamparsa.bsky.social
www.nature.com/articles/s41...

High conservation of Igµ BCR glycosylation across B cell subsets albeit limited contribution to BCR expression and function, suggesting BCR glycans may have evolved to support IgM antibody functions @natcomms.nature.com
www.nature.com/articles/s41...

Review @cellcellpress.bsky.social
Somatic genomics as a discovery engine for biomedicine
www.cell.com/cell/fulltex...

Harnessing skull bone marrow immune cells to deliver drug-loaded nanoparticles to injured brain regions improves outcomes and reveals a feasible translational strategy for targeted CNS therapy @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...

CLIM-TIME, a spatially resolved in vivo CRISPR screening platform linking loss of tumor suppressor genes to distinct metastatic immune architectures and divergent responses to immunotherapy @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...

IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and inhibitory CD300 family members Izawa et al. identify sphingomyelin and ceramide species as ligands for CD300d3 and CD300f. CD300d3 enhances IgE-mediated murine mast cell activation via its ligands, whereas CD300f inhibits it. Mast ...

IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and inhibitory CD300 family members @cp-cellreports.bsky.social www.cell.com/cell-reports...

Potentiating dendritic cell immunotherapy by interrupting the Semaphorin 4D-induced immune-suppressive barrier @cp-cellreports.bsky.social @moffittnews.bsky.social
www.cell.com/cell-reports...

Genetically engineered eye-colonizing microbes that deliver the anti-inflammatory cytokine IL-10 enhance corneal tissue repair @cp-cellreports.bsky.social
www.cell.com/cell-reports...

Influenza A virus polymerase co-opts distinct sets of host proteins for RNA transcription or replication
www.cell.com/cell-chemica... @imperialcollegeldn.bsky.social

Activation of vascular STING signaling restores NK cell infiltration and killing of neuroendocrine small cell lung cancer @cp-cancercell.bsky.social @danafarber.bsky.social
www.cell.com/cancer-cell/...

Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs @cellcellpress.bsky.social
www.cell.com/cell/fulltex...

Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain @cellcellpress.bsky.social
www.cell.com/cell/fulltex...

Hypothalamic paraventricular nucleus clock is a pharmacological node linking circadian amplitude to organismal aging @cellcellpress.bsky.social
www.cell.com/cell/fulltex... 🇨🇳