STITCHES Medicine - the Best of Medical Research

Cancer programs significantly boosted smoking cessation assistance from 48% to 68%, highlighting rapid, effective integration into patient care.

by Pu T, Burris JL (...) Mullett TW et 7 al. in J Clin Oncol #MedSky

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📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-01815

HPV vaccination dramatically cuts invasive cervical cancer risk, sustaining protection for over a decade, especially in school-based cohorts.

by Wu S, Deng Y (...) Lei J et 5 al. in BMJ #MedSky

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📖 read the article: https://www.bmj.com/content/392/bmj-2025-087326

Lay health worker interventions cut emergency department visits by 53% and hospitalizations by 68% in older cancer patients.

by Patel MI, Voskanyan M (...) Milstein A et 3 al. in JAMA #MedSky

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📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2843478

Axitinib Boosts Progression-Free Survival in Advanced Neuroendocrine Tumors, Yet Primary End Point Remains Unmet

by Garcia-Carbonero R, Benavent M (...) Capdevila J et 22 al. in J Clin Oncol #MedSky

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📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-01808

TAVR and surgical aortic-valve replacement yield similar long-term outcomes in low-risk patients with severe aortic stenosis after 7 years.

by Leon MB, Mack MJ (...) Makkar RR et 18 al. in N Engl J Med #MedSky

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📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2509766

Bispecific T cell engagers for treatment-refractory autoimmune connective tissue diseases - Nature Medicine In a case series of five patients with treatment-refractory antisynthetase syndrome and five patients with treatment-refractory systemic sclerosis, bispecific T cell engagers blinatumomab and teclistamab improved disease activity and were well tolerated.

Bispecific T cell engagers improve symptoms in patients with treatment-refractory autoimmune conditions, offering hope for effective rescue therapies.

by Düsing C, Györfi AH (...) Distler JHW et 28 al. in Nat Med #MedSky

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Disrupted neurovascular response in type 1 diabetes worsens with impaired awareness of hypoglycemia, revealing maladaptive brain and vascular dynamics.

by Filip P, Canna A (...) Mangia S et 7 al. in J Clin Invest #MedSky

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📖 read the article: https://www.jci.org/articles/view/199725

Neuronal SEL1L-HRD1 ERAD crucially regulates motor function and survival, revealing links to severe pediatric neurological disorders.

by Torres M, Lu Y (...) Qi L et 13 al. in J Clin Invest #MedSky

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📖 read the article: https://www.jci.org/articles/view/196819

Gene therapy with AAV9/SLC13A5 significantly rescues epilepsy and metabolic dysfunction in a mouse model of SLC13A5 disorder.

by Bailey LE, Adams RM (...) Bailey RM et 6 al. in J Clin Invest #MedSky

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📖 read the article: https://www.jci.org/articles/view/197503

Monthly cabotegravir-rilpivirine injections slash regimen failure rates by nearly 18% compared to standard oral ART for HIV patients.

by Rana AI, Zheng L (...) Landovitz RJ et 33 al. in N Engl J Med #MedSky

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📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2508228

Deciphering the etiology of the 2024 outbreak of undiagnosed febrile illness in Panzi, Democratic Republic of the Congo - Nature Medicine This multidisciplinary response to investigate the large outbreak of unknown febrile illness in the Panzi Health Zone in the Democratic Republic of the Congo in late 2024 suggests that the outbreak was largely associated with malarial cases and concurrent viral respiratory infections.

Malaria surge drives febrile illness outbreak in DRC, compounded by respiratory viral infections; urgent lab capacity upgrades needed for rapid response.

by Wawina-Bokalanga T, Makangara-Cigolo JC (...) Muyembe-Tamfum JJ et 44 al. in Nat Med #MedSky

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Type 1 diabetes, affecting millions, is marked by autoantibodies and demands lifelong insulin therapy for management.

by Jacobsen LM and Schatz DA in JAMA #MedSky

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📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2845229

Medicaid expansion boosts early NSCLC diagnosis, accelerates treatment, and improves 5-year survival rates, particularly for low-income patients.

by Zhao J, Graetz I (...) Lipscomb J et 5 al. in J Clin Oncol #MedSky

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📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-01892

Atacicept slashes proteinuria by 45.7% in IgA nephropathy patients, significantly outperforming placebo in Phase 3 trial.

by Lafayette R, Barbour SJ (...) Barratt J et 18 al. in N Engl J Med #MedSky

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📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2510198

NOAC monotherapy outperforms combination therapy for atrial fibrillation post-drug-eluting stent, reducing adverse events and bleeding risk.

by Lee SJ, Yu HT (...) Kim JS et 47 al. in N Engl J Med #MedSky

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📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2512091

Sibeprenlimab Cuts Proteinuria by Over 50% in IgA Nephropathy Patients, Demonstrating Promising Efficacy and Safety Profile

by Perkovic V, Trimarchi H (...) Rizk DV et 21 al. in N Engl J Med #MedSky

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📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2512133

Targeting mutant FGFR1 in high-risk neuroblastoma could reverse treatment failures, offering hope through FGFR-directed therapies in resistant cases.

by Werr L, Boland J (...) Fischer M et 44 al. in J Clin Invest #MedSky

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📖 read the article: https://www.jci.org/articles/view/189152

Higher initial oxygen levels during resuscitation of preterm infants do not reduce risks of death or brain injury.

by Oei JL, Kirby A (...) Tarnow-Mordi W et 41 al. in JAMA #MedSky

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📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2842699

Gene Therapy in Type II GM1 Gangliosidosis Shows Biochemical Improvements but Carries Significant Adverse Events in Children

by Lewis CJ, D'Souza P (...) Tifft CJ et 28 al. in N Engl J Med #MedSky

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📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2510935

Live-attenuated chikungunya vaccine in children: a randomized phase 2 trial - Nature Medicine In a phase 2 randomized, controlled, dose–response trial, the live-attenuated chikungunya vaccine (VLA1553) was given in full and half doses to children under the age of 12 in Honduras and the Dominican Republic and was found to be safe and immunogenic, with the results supporting selection of the full-dose VLA1553 in future clinical trials in this population.

Chikungunya vaccine trial in children shows full-dose VLA1553 is safe and boosts antibody levels, paving way for future development.

by Weisová P, Scheiblauer S (...) Jaramillo JC et 15 al. in Nat Med #MedSky

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Revising statin product labels: only four adverse effects supported by randomized trials; most listed conditions lack causal links.

by None None; None None in Lancet #MedSky

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📖 read the article: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01578-8/fulltext

Tenecteplase boosts recovery in non-large vessel occlusion stroke patients beyond 4.5 hours but raises risk of intracranial hemorrhage.

by Ma G, Mo R (...) Hao J et 45 al. in JAMA #MedSky

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📖 read the article: https://jamanetwork.com/journals/jama/fullarticle/2844754

Trans-sialidase peptide TS23 shows significant promise as a universal diagnostic target for Chagas disease across Americas’ endemic regions.

by Kortbawi HM, Marczak RJ (...) Whitman JD et 22 al. in J Clin Invest #MedSky

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📖 read the article: https://www.jci.org/articles/view/199277

TP53/TAU axis crucially orchestrates microtubule bundling, enabling alveolar stem cells to regenerate thin epithelial lung cells post-injury.

by Konishi S, Enkhbayar K (...) Tata PR et 11 al. in J Clin Invest #MedSky

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📖 read the article: https://www.jci.org/articles/view/194762

WHO advocates for GLP-1 therapies, combining them with behavioral interventions to tackle obesity as a chronic, relapsing disease.

by Celletti F, Farrar J and De Regil L in JAMA #MedSky

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📖 read the article: https://jamanetwork.com/journals/jama/fullarticle/2842199

ctDNA detection post-surgery in stage III colon cancer predicts poor outcomes, guiding personalized adjuvant therapy for high-risk patients.

by Sinicrope FA, Segovia D (...) Shi Q et 4 al. in J Clin Oncol #MedSky

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📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-02086

Etranacogene dezaparvovec slashes annual bleeding rates by 63% in hemophilia B, maintaining stable factor IX levels over five years.

by Pipe SW, Miesbach W (...) Monahan PE et 10 al. in N Engl J Med #MedSky

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📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2514332

Tenecteplase fails to outperform aspirin for vision recovery in acute central retinal artery occlusion and raises safety concerns.

by Ryan SJ, Jørstad ØK (...) Aamodt AH et 46 al. in N Engl J Med #MedSky

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📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2508515

Parental firearm injuries spike psychiatric disorders and mental health visits in children, with trauma-related diagnoses hitting hardest.

by Karandinos G, Giuriato M (...) Sacks CA et 4 al. in N Engl J Med #MedSky

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📖 read the article: https://www.nejm.org/doi/10.1056/NEJMsa2502702

ADAMTS7 drives atherosclerosis by expanding smooth muscle foam cells via an AP-1/PU.1/CD36 regulatory axis, fueling vascular injury.

by Chung A, Fries LE (...) Bauer RC et 9 al. in J Clin Invest #MedSky

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📖 read the article: https://www.jci.org/articles/view/187451