Nature Reviews Immunology

Progress in the development of cytokine armoured CAR T cells Nature Reviews Immunology, Published online: 06 March 2026; doi:10.1038/s41577-026-01280-8Cytokine-armoured CAR T cells represent a new generation of programmable cell therapies designed to enhance efficacy while limiting toxicity. This Review explores how cytokine armouring and advances in synthetic receptor design and conditional gene circuits are reshaping immunotherapy for solid tumours.

Progress in the development of cytokine armoured CAR T cells

ICYMI: Checkpoint blockade amplifies pro-regenerative type 2 immunity in tissue repair

Androgens help monocytes deliver pain relief Nature Reviews Immunology, Published online: 05 March 2026; doi:10.1038/s41577-026-01287-1Androgens support IL-10-expressing monocytes that alleviate inflammatory pain.

ICYMI: Androgens help monocytes deliver pain relief

Further discussion from @preprintclub.bsky.social here:
www.preprintclub.com/preprint-rev...

Original preprint here: www.biorxiv.org/content/10.6...

NEW Journal Club by Sinibaldo Romero Arocha & Alexander Clarke @preprintclub.bsky.social discusses @biorxiv-immuno.bsky.social preprint by Garcia et al. @jhelisseeff.bsky.social showing that immune checkpoint pathways calibrate tissue repair in a non-malignant setting

Reporter, Nature News Job Title: Reporter, Nature Location: Washington DC or New York (Hybrid Working Model) Application Deadline: March 27, 2026 About Springer Nature Springer Nature is one of the leading publishers of re...

Nature Magazine is hiring! This is a rare and wonderful chance to join our US news team as a physical sciences reporter. US$85,000 - $100,000. Based in Washington, DC or New York City (you must have the right to work in the US, sorry). springernature.wd3.myworkdayjobs.com/SpringerNatu...

Checkpoint blockade amplifies pro-regenerative type 2 immunity in tissue repair

Androgens help monocytes deliver pain relief Nature Reviews Immunology, Published online: 05 March 2026; doi:10.1038/s41577-026-01287-1Androgens support IL-10-expressing monocytes that alleviate inflammatory pain.

Androgens help monocytes deliver pain relief

⌛️ Final reminder! Submit your immune metabolism research abstract before tomorrow!

Click here: bit.ly/493uE45

Want to understand how the immune system works?

Our ‘Foundations of immunology’ course is on 18 March. Learn the fundamentals of immunology, from immune defence to vaccines & immunotherapies.

📊 Past attendees reported a 76% increase in confidence!

🔗 bit.ly/4reoIfv

You can also register to join virtually if you can't make IRL...

World Immunology Day 2026 | Inflammation: the good, the bad and the chronic

If you're in London on 30th April, join us at the Crick for our public outreach event on inflammation: www.crick.ac.uk/whats-on/wor...

Registration Now Open for Day of Immunology 2026! » IUIS We are thrilled to announce that registration is officially open for the Day of Immunology 2026 webinar, taking place on 29 April 2026! This year’s theme, “Regulatory T Cells: Guardians of Immune…

On April 29th, @iuis-online.bsky.social will celebrate the day of immunology with a special webinar on Treg cells. Register here: iuis.org/news/registr...

Intermittent fasting evicts long-lived plasma cells from survival niche Nature Reviews Immunology, Published online: 27 February 2026; doi:10.1038/s41577-026-01286-2Zhu et al. report in Immunity that ketogenesis resulting from intermittent fasting causes the downregulation of CXCR4 expression on plasma cells, triggering their egress from the bone marrow and impaired humoral immunity.

ICYMI: Intermittent fasting evicts long-lived plasma cells from survival niche

Intermittent fasting evicts long-lived plasma cells from survival niche Nature Reviews Immunology, Published online: 27 February 2026; doi:10.1038/s41577-026-01286-2Zhu et al. report in Immunity that ketogenesis resulting from intermittent fasting causes the downregulation of CXCR4 expression on plasma cells, triggering their egress from the bone marrow and impaired humoral immunity.

Intermittent fasting evicts long-lived plasma cells from survival niche

Intermittent fasting evicts long-lived plasma cells from survival niche Nature Reviews Immunology - Zhu et al. report in Immunity that ketogenesis resulting from intermittent fasting causes the downregulation of CXCR4 expression on plasma cells, triggering their egress...

NEW online: Highlight of an @cp-immunity.bsky.social paper by @lab-of-plasma-cell.bsky.social showing that intermittent fasting in mice impairs the maintenance of humoral memory by depleting long-lived plasma cells.

rdcu.be/e53h0

Sweets from Paris

Was great to have @adeczkowska.bsky.social here, who delivered science & sweets from @aleksdelab.bsky.social of @pasteur.fr. Even more: She pointed out this stimulating essay by Ruslan Medzhitov on the balance of knowledge in immunology: www.nature.com/articles/s41... 🧪 @natrevimmunol.nature.com

🗓️ One month to go!

Vaccine Engagement Day 2026 is on 25 March. Our campaign resources are now live, so get ready to #CelebrateVaccines and highlight the vital role immunisation plays in protecting individuals & communities.

🔗 Learn more here: https://bit.ly/3MI35X0

Do you: Have a strong interest in science? A passion for journalism and writing? Our paid 3-month internship might be for you! We are looking for talented candidates from all backgrounds, especially those traditionally underrepresented in publishing. Applications close 9 March 2026.

Calling all budding science writers!

Applications for our paid London-based internship, starting in June, are now open.

Deadline: 9 March 2026

Full info here: springernature.wd3.myworkdayjobs.com/en-US/Spring...

#PaidInternship #Internship #Journalism

Highly dynamic dural sinuses support meningeal immunity - Nature Microscopic imaging and biochemical studies show that sinuses in mouse and human form a highly dynamic surface that regulates fluid movement and immune cell surveillance via RAMP1-dependent regulation of smooth muscle contraction and RAMP2-dependent regulation of the sinus endothelial barrier.

Nature research paper: Highly dynamic dural sinuses support meningeal immunity

go.nature.com/4cIh5KG

Roads and detours for CAR T cell therapy in autoimmune diseases Nature Reviews Drug Discovery - Following on from its success in eradicating malignant B cells in cancer, chimeric antigen receptor (CAR) T cell therapy has been extended to treat autoimmune...

CAR-T cell therapies that deplete pathogenic B cells have recently shown promise in clinical trials for autoimmune diseases such as lupus. This Review discusses the prospects and challenges in the field
rdcu.be/e5vPk
www.nature.com/articles/s41...

Overcoming xenotransplantation barriers through gene editing and immunomodulation Nature Reviews Bioengineering, Published online: 23 February 2026; doi:10.1038/s44222-026-00412-yXenotransplantation aims to address the shortage of human organs by using organs from species other than human; in particular, porcine organs share similarities with human organs in key aspects. This Review highlights major challenges in xenotransplantation, such as immune rejection and disease transmission, and explores solutions, such as gene editing, immunomodulation, and robust safety and ethical frameworks to enable future success.

Overcoming xenotransplantation barriers through gene editing and immunomodulation

How to get a universal vaccine vs respiratory threats?
Block via the nasal mucosa
@science.org
www.science.org/doi/10.1126/...
@natrevimmunol.nature.com
www.nature.com/articles/s41...

Global immunology education: 20 years of Immunopaedia Nature Reviews Immunology, Published online: 20 February 2026; doi:10.1038/s41577-026-01282-6Immunopaedia is a free educational platform that teaches immunological concepts through clinical case studies.

ICYMI: Global immunology education: 20 years of Immunopaedia

Global immunology education: 20 years of Immunopaedia Nature Reviews Immunology, Published online: 20 February 2026; doi:10.1038/s41577-026-01282-6Immunopaedia is a free educational platform that teaches immunological concepts through clinical case studies.

Global immunology education: 20 years of Immunopaedia

See NRI's conference calendar for upcoming immunology events: www.nature.com/nri/conferen... Get in touch if you have any events you'd like us to add.

Registration Now Open for Day of Immunology 2026! » IUIS We are thrilled to announce that registration is officially open for the Day of Immunology 2026 webinar, taking place on 29 April 2026! This year’s theme, “Regulatory T Cells: Guardians of Immune…

On April 29th, @iuis-online.bsky.social will celebrate the day of immunology with a special webinar on Treg cells. Register here: iuis.org/news/registr...

World Immunology Day 2026 | Inflammation: the good, the bad and the chronic

If you're in London on 30th April, join us at the Crick for our public outreach event on inflammation: www.crick.ac.uk/whats-on/wor...

Review @natrevdrugdiscov.nature.com
Therapeutic targeting of neuroimmune mechanisms in neurodegeneration
www.nature.com/articles/s41...