LPJ Lab - Neuroimmunometabolism

Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA‐DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset [Color figure can be viewed at www.annalsofneurology.org]

Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA-DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset

onlinelibrary.wiley.com/doi/full/10....

Check out ISSCR's society journal, Stem Cell Reports!

I am delighted to share that I have been appointed as Early Career Editor for @stemcellreports.bsky.social, the official journal of the International Society for Stem Cell Research @isscr.org! 🔬🌍
I look forward to seeing your research in the field of stem cells!
Submit here: invt.io/1bxb9kpdtfj 👍

⚠️ We are hiring a Postdoctoral Research Associate ⚠️
🚨 Deadline 9th February 2026 🚨
👍 Please like and share with your network! 👍

#CambridgeUniversity #PostdoctoralResearch #JobOpportunity

For enquiries please contact me at LP429@CAM.AC.UK or use this 🔗 to apply: www.cam.ac.uk/jobs/postdoc...

Act Now: Tell Congress to Act on PBM Reform Before January 30 Contact Congress today!

🚨ALERT: If you live in the USA, please contact Congress to prioritize Pharmacy Benefit Manager (PBM) reform, so that people with multiple sclerosis receive the medications meant for them!🚨 #MS #Healthcare
Please click and act here before the ⚠️Jan 30 deadline⚠️: nmss.quorum.us/campaign/152...

New insight into the immune signals driving inflammation in multiple sclerosis Multiple sclerosis (MS) is a chronic neurological disease characterized by nerve damage and consequent impairments in vision, movement, balance and mental function.

A new CRISPR-based approach has identified key immune signals that regulate macrophage behavior in multiple sclerosis, offering deeper insight into the mechanisms driving neuroinflammation. doi.org/hbjfrf

3 papers on EBV and MS

Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis

Anoctamin-2 (ANO2) is targeted by T cells in approximately 57% of persons with MS

www.cell.com/cell/fu...
1/6

The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.

REVIEW | E Asimakidou, @lpjlab.org et al. (U Cambridge)

How metabolic interactions between microglia and neurons shape brain health 🧪

Merry Christmas from the LPJ Lab! 🎄
It’s been a joy to see the lab grow in 2025. I’m incredibly proud of this brilliant team and our shared mission to improve the lives of those with incurable diseases.
Here’s to the challenges ahead! 💪
@camneuro.bsky.social
@camneurodept.bsky.social
@cam.ac.uk

Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy…

New research in Nature Metabolism reveals that neuronal fatty acid oxidation is crucial for fueling memory formation after intensive learning. This metabolic shift supports the high energy demands in fruit flies. 🧠🪰
#Neuroscience #Metabolism #Memory
www.nature.com/articles/s42...

Neural Circuits of behavior: from synapses to action | ScuolaNormaleSuperiore

Please share the next "Neural Circuits of behavior" school in #Pisa, organised by @biancasilvalab.bsky.social

We will be exploring how #neuroplasticity shapes the #brain and #cognition 🧠
#NeuroSky #Neuroscience

⚠️ Applications and #scholarships are open until 15/01/26 ⚠️

www.sns.it/it/evento/ne...

Just wrapped up the CAJAL Advanced Neuroscience Training Programme in Bordeaux! 🍷🧠
It was a privilege to introduce such a brilliant group of students to the world of #Neuroimmunometabolism.
The future of our field looks very bright!
#Neuroscience #Immunology #Cajal #Bordeaux

tinyurl.com/276b6upe

The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.

⚠️ Just out in @natmetabolism.nature.com ⚠️

Our latest review with @pluchinolab.bsky.social & @biancasilvalab.bsky.social explores how #microglia and #neuron #metabolism shapes #brain health and cognition! 🧠

Our Evridiki Asimakidou did a wonderful job leading this! 👏

www.nature.com/articles/s42...

Metabolic Messengers: itaconate McGettrick et al. provide a succinct yet broad overview of the immunometabolite itaconate as an immunomodulatory molecule.

New Nature Metabolism review breaks down the history, role, and therapeutic promise of itaconate. Learn how this metabolite exerts potent anti-inflammatory effects—a crucial mechanism for future drug development!
#Immunometabolism #Inflammation
www.nature.com/articles/s42...

Fascinating read on #brain 🧠 tumor #immunology! Primary brain tumors vs metastases have fundamentally different immune microenvironments.
This is why secondaries often show a better response to #immunotherapy. share.google/RJdXIc02PCyH...

The immunology of brain tumors The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/...

Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.

Metabolic and transcriptional adaptations to phagocytosis sustain microglia functionality and regenerative properties Phagocytosis of apoptotic cells, or efferocytosis, is a tightly regulated process that ensures tissue homeostasis and prevents mounting inflammatory responses. In the brain parenchyma, it is executed ...

New preprint: #Microglia don't just clear debris - they undergo a massive metabolic overhaul after phagocytosis, including adaptive mitochondrial changes, which may make them pro-regenerative! 🥳🧠💪
#Neuroscience #Mitochondria #Metabolism #BioRxiv

www.biorxiv.org/content/10.1...

Use the form on our website! www.LPJLab.org

Funding Funding is often secured through Wellcome Trust or MRC DTP Fellowships. Further information about this and specific projects studying under the supervision of Departmental supervisors who have obtaine...

#PhD position available!

Our collaborator Roberta Magliozzi is looking for a motivated student to map the meningeal immune landscape in #MultipleSclerosis.
This is a great opportunity for anyone interested in neuroimmunology! 🧠

Please SHARE and APPLY here:
www.imperial.ac.uk/brain-scienc...

Thank you, Stuart!
Glad you were able to attend. CNS inflammation is such an important and evolving area of neuroscience. I think it's a field with immense potential for new discoveries and tangible patient benefits.

Session Six featured fantastic talks by Prof. Vendeuscolo from the Dept. of Chemistry @cam.ac.uk, Prof. Peruzzotti-Jametti from the Dept. of Clinical Neurosciences @cam.ac.uk, and the Andrew Huxley Plenary Lecture by our special guest Prof. Studer from the Sloan Kettering Cancer Center, NY
#CNS2025

Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies Human myelinated brain organoids with integrated microglia can be used to investigate demyelination, remyelination, and remyelinating therapies.

Human myelinated brain organoids with integrated #microglia as a model for #myelin repair and remyelinating therapies | Science Translational Medicine
www.science.org/doi/10.1126/...

Hope for Myelin Repair: Stem Cells & Progressive MS Can neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.

An interview with Dr. Luca Peruzzotti Jametti on the topic of #Myelin repair.

ms-perspektive.de/en/129-luca-...

#MSchat #MultipleSclerosis #Neurology #StemCells @pluchinolab.bsky.social @restorems.bsky.social @lpjlab.org

Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience A single-cell epigenomic and transcriptomic atlas across six brain regions in Alzheimer’s disease reveals widespread epigenomic relaxation and information loss, associated with the selective depletion...

Groundbreaking new paper on #Alzheimers disease: researchers found widespread "epigenome erosion" that is linked to cell-type-specific and region-specific changes that correspond with #microglial cell shifts, cognitive decline, and even cognitive resilience!

www.cell.com/cell/fulltex...

Hope for Myelin Repair: Stem Cells & Progressive MS Can neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.

Excited to share that I was a guest on MS-Perspektive - The #MultipleSclerosis #Podcast with Nele von Horsten! 🎧

We had a great chat about the latest research in MS and how we're working to find new treatments. 💪

Listen to the full episode here 👇
ms-perspektive.com/129-luca-per...

MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation - Nature Cancer Cangkrama et al. show that tumor cells from various cancer types use the mitochondrial trafficking protein MIRO2 and nanotubes to transfer mitochondria into surrounding fibroblasts, thereby inducing c...

www.nature.com/articles/s43... reproduced in vitro thanks to #FluidFM

Synthetic torpor: advancing metabolic regulation for medical innovations - Nature Metabolism Chen et al. provide an overview of historical and more recent approaches for the induction of synthetic torpor, and discuss their potential medical applications.

PERSPECTIVE | W Wu, H Chen et al. (Wash U St Louis)


An overview of historical and more recent approaches for the induction of synthetic torpor and their potential medical application

https://bit.ly/4mBb9FF ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab

Absolutely! And I was happy to see that we share the same opinions! 😁

Beyond understanding the #brain, our goal is to heal it!
www.lpjlab.org/news-1/8dgsijj0s02907evez1bmai1fht6pa

Join us on September 10-11 at the 8th #Cambridge #Neuroscience Symposium to explore the latest breakthroughs that are poised to transform #patient care!

Register here: tinyurl.com/27rzs5ku

The debate on intercellular mitochondrial transfer is heating up! In this new Viewpoint, eminent scientists in the field of mitochondrial biology, including our friend @rubenqc-lab.bsky.social, share their views on the topic.
Dive in and let us know what you think!

www.nature.com/articles/s42...

Cool event alert! 🧠
The next European Microglial Webinar is happening on Tuesday, 02/09 at 5pm CEST / 3pm GMT.
Michael Dolan will be speaking on "Formation and Function of Microglial States in Remyelination."
Zoom Link: unil.zoom.us/j/93018596158
#Microglia #Neuroscience