From earlier this week: How do the skin’s immune cells hit a moving target in Lyme disease?
Linda K. Bockenstedt & team analyzed immune responses in Lyme disease-induced skin rashes, identifying unique immune cell types that could play roles in defense or disease mechanisms: doi.org/10.1172/jci....
Excited to share new work from our lab in @insight.jci.org 🎉
We find that #CD9 is a key regulator of adipose tissue lipid-associated macrophages #LAMs in obesity. Deleting CD9 improves metabolism in obese mice.
Credit to first author Julia Chini and team!
Read now:
insight.jci.org/articles/vie...
Anoikis resistance and metastasis of ovarian cancer can be overcome by CDK8/19 mediator kinase inhibition
Most cells die after detachment; aggressive cancer cells do not.
Using comprehensive models, Karthikeyan Mythreye & team reveal CDK8/19 as a drug target that could prevent/treat ovarian cancer spread by blocking cancer cells' survival in circulation: doi.org/10.1172/jci....
Characterization of the clonal hierarchy and immunophenotype of PTPN11 mutations in acute myeloid leukemia
The pathogenic contribution of PTPN11 mutations to AML has been unclear
John C. Byrd & team reveal PTPN11 mutations in AML can be early events in the clonal evolution of disease development and are associated with variably differentiated myeloid cells: doi.org/10.1172/jci....
Single-cell immunophenotyping identifies CD8+GZMK+IFNG+ T cells as a key immune population in cutaneous Lyme disease
How do the skin’s immune cells hit a moving target in Lyme disease?
Linda K. Bockenstedt & team analyzed immune responses in Lyme disease-induced skin rashes, identifying unique immune cell types that could play roles in defense or disease mechanisms: doi.org/10.1172/jci....
GLP-1 medicines have multiple direct and indirect effects that modify cardiovascular risk. Here Kyle Medak @SinaiHealth and colleagues identify an important role for the VSM GLP-1R in the reduction of blood pressure #hypertension @JCI_insight @uoftmedicine insight.jci.org/articles/vie...
New from Megan Capozzi @UW Postprandial glycogen repletion and the surprising role of glucagon insight.jci.org/articles/vie... @insight.jci.org
Infografik: A mutated TLR8 gets degraded faster however forms a more stable TLR8 homodimer that leads to increased activation and inflammatory signals.
TLR8 helps the body detect viral genetic material — but what happens when it’s mutated?
A new study in @insight.jci.org from scientists from @leibnizliv.bsky.social, DZKJ and collaborators combines computational modeling and functional experiments to find out:
insight.jci.org/articles/vie...
Presenting a side-by-side single-cell comparison of 3 COVID-19 vaccines:
Duygu Ucar & team reveal primary and secondary mRNA vaccines elicit distinct innate responses driven by Type-I and Type-II interferons, respectively: doi.org/10.1172/jci....
Sequencing has aided in the discovery of mutations in inborn errors of immunity, but their clinical relevance is often unclear
Altfeld & team @leibnizliv.bsky.social identify a TLR8 mutation causing immune overactivation & inflammation in 2 siblings: doi.org/10.1172/jci....
ICYMI: Review: New approaches to uncover COPD pathobiology and to develop therapies
Tesfaigzi et al. summarize topics covered by the COPDiNET symposium, focusing on 5 areas: genetics, environmental factors, model systems, drug development, & new technologies: doi.org/10.1172/jci....
ICYMI: Suggesting a potential therapy for these autism-related symptoms and intellectual disability…
This issue’s Cover features work by Hannelore Ehrenreich & team on the improvement of Primose syndrome traits in mice following erythropoietin treatment: doi.org/10.1172/jci....
Another way SARS-CoV-2 cuts through immune defenses
Zoltan Arany & team identify putative host cleavage targets of the SARS-CoV-2 protease 3CLPro, revealing a mechanism by which the virus weakens host innate immunity in individuals with protective OAS1: doi.org/10.1172/jci....
New paper in insight.jci.org by my & Ling Lin’s groups! TB is the most common infectious disease that causes death, causing >1 million deaths globally. HIV is the greatest risk factor for TB, causing worse clinical outcomes for both infections. We studied the effect of SIV infection 1/4
Does suppression of HIV replication protect against severe Mtb infection?
ASCI member Philana Ling Lin & team report on SIV/ART/TB models, finding antiretroviral treatment reduces pulmonary TB pathology, yet does not prevent extrapulmonary spread of TB: doi.org/10.1172/jci....
So thrilled to have our research as a cover feature at @insight.jci.org, showing recombinant human Erythropoetin can compensate for the loss of function caused by the genetic mutation.
I hope this research will age well.
Thanks Hannelore, Klaus, @cakirumut.bsky.social , Justus and ex-colleagues
Structural and functional gastrointestinal abnormalities in ACTA2 R179H mice modeling multisystemic smooth muscle dysfunction syndrome
Multisystemic Smooth Muscle Dysfunction Syndrome is a pediatric condition associated with gut dysmotility.
Here, Goldstein & team show intestinal dysmotility is linked to disrupted smooth muscle function in ACTA2 R179H mice modeling MSMDS: doi.org/10.1172/jci....
Behind the scenes at the Pantopoulos Lab: (from left to right): Sofiya Tsyplenkova, Carine Fillebeen (in front), Sabrina Sgro (at the back), Kostas Pantopoulos, Tao Zhao and Wen Gu — posing, then making science happen.
IRP1 deficiency alters mitochondrial metabolism and protects against metabolic syndrome pathologies
This Research Article uncovers an unexpected function of iron regulatory protein 1 in metabolic regulation.
Kostas Pantopoulos & team find mice that lack IRP1 have altered energy metabolism and are protected against metabolic syndrome pathologies: doi.org/10.1172/jci....
Review: New approaches to uncover COPD pathobiology and to develop therapies
Tesfaigzi et al. summarize topics covered by the COPDiNET symposium, focusing on 5 areas: genetics, environmental factors, model systems, drug development, & new technologies: doi.org/10.1172/jci....
Suggesting a potential therapy for these autism-related symptoms and intellectual disability…
This issue’s Cover features work by Hannelore Ehrenreich & team on the improvement of Primose syndrome traits in mice following erythropoietin treatment: doi.org/10.1172/jci....
ft. Julia Chini, Samuel McCright, Nicole DeMarco, Dana Mitchell, Divyansi Pandey, Rachel Clement, Jessica Miller, Deanne Taylor, @drdavidhill.bsky.social (@chopresearch.bsky.social) Kaitlyn Shen, Mitchell Lazar & Rajan Jain (@pennmedicine.bsky.social) @insight.jci.org insight.jci.org/articles/vie...
ICYMI: Germline mutations in DICER1 and DGCR8 can lead to a range of thyroid conditions
Barbara Rivera & team report on the benign-to-malignant progression route in DICER1/DGCR8-thyroid lesions, identifying a DICER1-cancer epi-signature via multi-omic profiling: doi.org/10.1172/jci....
Previously shared: The morning advantage…
Jeffrey A. Haspel & team perform an observational study of 715 patients, reporting a connection between the time of day when CAR T-cell cancer immunotherapy is administered and its effectiveness: doi.org/10.1172/jci....
Murray CH. Clarke @murrayclarkelab.bsky.social & team find common CHIP mutations produce distinct sex-dependent effects on atherosclerosis and differentially affect macrophage cytokines and clonal expansion, arguing against a common mechanism across CHIP: doi.org/10.1172/jci....
