Jason Hassenstab

Voting closes Monday on the 2026 International Neuropsychological Society elections!

Read about all the candidates, including me for President at the-ins.org/ins-election...

Thank you for your consideration! @ytquiroz.bsky.social @sdukehan.bsky.social @ctrlab.org
@amygdalaphd.bsky.social

Sharper in the morning: Cognitive time of day effects revealed with high-frequency smartphone testing Decades of research has established a shift from an “eveningness” preference to a “morningness” preference with increasing age. Accordingly, older adults typically have better cognition in morning hou...

Thanks! And yes you are on to something with testing people under "stress" of different kinds. In another paper by my PhD student Hannah Wilks, we found that testing OAs in the evening revealed about 10% more memory deficits in those with AD pathology. pmc.ncbi.nlm.nih.gov/articles/PMC...

Overall, we think it sends a pretty positive message about the validity of remote, unsupervised #digitalcognition #EMA, in general. But of course we have to collect information about environments and especially distractions.

One surprise was that the number of sessions where participants reported distractions was about 12% of sessions. So distractions are very very common and its really important to allow participants to tell you when they experience them in remote studies. 4/n

However, for those with very mild dementia (consistent with Mild Cognitive Impairment), environments and distractions started to matter more. Taking tests away from home AND when around others impacted those with cognitive symptoms. 3/n

We followed 380 cognitively normal (CN) older adults and 37 with very mild dementia with our smartphone #EMA platform called ARC. For the CNs, it didn't seem to matter if tests were taken at home or around others. Even sessions where overt distractions were experienced didn't matter. 2/n

Impacts of Environmental Distractions and Interruptions on Unsupervised Digital Cognitive Assessments in Older Adults: Cognitive Ecological Momentary Assessment Study Background: Unsupervised cognitive assessments are becoming commonly used in studies of aging and neurodegenerative diseases. Because assessments are completed in everyday environments and without a p...

New paper from the lab. First author @mwelhaf.bsky.social, now in a TT position at North Carolina A&T. We wanted to know how environmental contexts and self-reported distractions impacted cognitive #EMA in older adults. mhealth.jmir.org/2025/1/e71578 1/n

Top scientists warn that Trump policies are causing a 'climate of fear' in research Some 2,000 scientists, including dozens of Nobel Prize winners, have signed an open letter warning that the U.S. lead in science is being "decimated" by the Trump administration's cuts to research.

Some 2,000 scientists, including dozens of Nobel Prize winners, have signed an open letter warning that the U.S. lead in science is being "decimated" by the Trump administration's cuts to research.

The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI) The presence of multiple pathologies is the largest predictor of dementia. A major gap in the field is the in vivo detection of mixed pathologies and their antecedents. The Alzheimer's Disease Resea...

The ADRC Consortium for Clarity in ADRD Research Through Imaging (CLARiTI) revolutionizes in vivo characterization of mixed pathologies #AlzResearch

Learn about this unprecedented publicly available imaging–plasma–neuropath dataset in A&D:
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

St. Louis study shows that drug may prevent Alzheimer’s. NIH slowdowns threaten future research Washington University-led research shows a small group of participants in an Alzheimer’s study experienced a significant delay in the onset of symptoms.

Washington University-led research shows a small group of participants in an Alzheimer’s study experienced a significant delay in the onset of symptoms.

Researchers find a hint at how to delay Alzheimer's symptoms. Now they have to prove it An experimental treatment appears to postpone Alzheimer's symptoms in some people genetically destined to get the disease at a young age.

"This treatment has given me an extension to my life that I never banked on having." A groundbreaking Alzheimer’s study led by WashU Medicine researchers shows promise in delaying symptom onset that could change the lives of those genetically at risk. apnews.com/article/alzh...

Had a fantastic time visiting @ctrlab.org in STL, presenting at the Washington University Aging & Development seminar, watching Dr. Hassenstab kick a$$ teaching Psych students, great dinner with Wash U friends and finishing off with a brewery tour! Whirlwind couple of days. Thanks Jason!

This is amazing. Thanks!

Great resources here for those of us interested in Ecological Momentary Assessment #EMA #ENDALZ

Trump’s siege of science: how the first 30 days unfolded and what’s next The breakneck pace and devastating impact of the administration’s policy changes has shocked researchers.

Trump’s siege of science: how the first 30 days unfolded & what’s next

Once upon a time leaders believed that science was essential to nation’s security, to better health, to more jobs, to a higher standard of living & to cultural progress
🧪 #academicSky
@nature.com
www.nature.com/articles/d41...

LOL Just like STL. Don't you miss us?

So humbled to be recognized as Distinguished Finalist for the Bold Pioneer Award...! Congrats to my fellow winners, and many thanks to prof Scheltens, prof Hassenstab, @washuneurology.bsky.social , and everyone who has encouraged me. It means a lot to me! 💜 @ctrlab.org
tinyurl.com/boldpioneer

There is no ‘amyloid cabal’ in Alzheimer’s research “There exists no ‘amyloid cabal’” in Alzheimer’s research, neurologist Dennis Selkoe writes in response to Charles Piller’s “Doctored.”

Definitely worth a read. #endalz www.statnews.com/2025/02/14/a...

Federal judge halts Trump administration cuts to NIH research payments in 22 states Attorneys general sued the Trump administration to block a NIH decision that would slash grant payments for research overhead

The entire landscape of medical research is shifting on an hour to hour basis. The whiplash is stupefying. As of now (Monday evening) the NIH 15% cap on indirects has been halted by a judge in 22 states but who knows what tomorrow brings www.statnews.com/2025/02/10/n...

This campaign needs you now Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

chng.it/WJznM2Lzgp
Let’s go!!!

What The NIH Cut To Indirect Cost Payments Could Cost Red States The Trump administration’s decision to cap how much NIH will pay for indirect costs on university research grants would cost 10 red states more than $1 billion.

Alzheimer’s disease is non-partisan. Cancer is non-partisan. Diabetes is non-partisan. This is a short-sighted policy that could cost thousands of jobs and set biomedical research progress back by years. Contact your local representatives and urge them to stand against this dangerous policy.

The brain’s action-mode is created by a dedicated action-mode network (AMN) rdcu.be/d5odm. In the brain’s mode continuum, AMN sits opposite DMN’s default-mode, as yin-yang. AMN might be key in pain, apathy, Parkinson’s. New @natrevneurosci.bsky.social w/ Marc Raichle & @gordonneuro.bsky.social 🧵 ⬇️

Great info here! Focusing on women's brain health is key for solving #Alzheimers disease #ENDALZ. From one of my good friends @bucklr01.bsky.social 🧠 🧪. Plus her 🇦🇺 accent makes everything sound optimistic 🦘.

Late‐life social activity and subsequent risk of dementia and mild cognitive impairment INTRODUCTION Social activity is associated with better cognitive health in old age. To better translate epidemiological research for public health communication, we estimated relations of levels of .....

Critical findings from my man @bryandjames.bsky.social at Rush Alzheimer's Disease Research Center. Social activities may delay dementia onset by 5 years. That delay could result in $500,000 savings in healthcare costs. #ENDALZ #Alzheimer's

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

I must have sent out 30-40 requests. Thank you!!

a woman with her eyes closed and the words please do this for me above her ALT: a woman with her eyes closed and the words please do this for me above her

Colleagues who accept review requests during this time of year: We editors love you. Very much. #ENDALZ

A interesting body of commentary from key people on this critically important topic. Definitely worth a read. Is removing substantial amyloid plus meeting safety targets enough to approve a treatment for #Alzheimer's? #ENDALZ

www.alzforum.org/news/researc...

Assistant Professor- Tenure Track, Clinical Neuropsychology University of California, Irvine is hiring. Apply now!

🚨🔔Calling all Neuropsychologists and those who know and support them!!!

Check out a new position posting here.

Come join me and other awesome colleagues @ucimind.bsky.social @ucirvine.bsky.social 🚨🔔

recruit.ap.uci.edu/JPF09362

Incredible thread detailing a biochemist's experience as an expert witness. The supplement Prevagen is advertised widely and patients concerned about their memory often ask us if it is effective. TLDR: Most of the effective ingredient can't withstand more than 30 seconds in the stomach. #ENDALZ