Soragni:Lab

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...

More functional data, many thousands of words removed, and a few other updates from last year's preprint.

Laboratory Assistant II - Human Genetics - UCLA Health Careers - Job #29031 - Los Angeles, CA Take a look at a great career opportunity where you can make a real difference at UCLA Health

We're hiring villagers!

We are looking for a lab technician to help us discover how gene-by-environment interactions shape the developing brain via in vitro cell villages. Please DM me or visit our website at mfwellslab dot com for more info.

Deadline to apply is March 11th: tinyurl.com/34seyjaj

On the side of small gripes: I'll never find reasonable to be asked to be online at 5am to review grants especially now that paylines are gone-and so are grants. It's unreasonably burdensome for all, even more so for those getting children ready for/to school. If the goal is inclusion, 5am is not it

That's right. Worse than Pointless
www.nytimes.com/2026/02/23/o...

This is a graph of the death of US science.

It's a tragedy. I hope no one thinks that we are over the hump. This is quite literally how federally supported science goes extinct.

White House stalls release of approved US science budgets The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers.

The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

Finally, today's offering! www.biorxiv.org/content/10.6...

This began life as a very different project which failed because we couldn't agree on defining eqtl sharing across cohorts. So two young members of the lab dug deeply into this - first @ijbeasley.bsky.social, then @patrickgibbs.bsky.social

New version of our preprint on bioRxiv about bioRxiv up. Now that’s what I call a revision – 6 years after the first version!
It has new data about our progress and highlights from a massive user survey. 1/n
www.biorxiv.org/content/10.1...

CU Anschutz Recruits National Leader to Launch Functional Personalized Medicine Initiative National leader in tumor organoids Alice Soragni, PhD, launches a rapid functional precision medicine initiative at CU Anschutz within CCPM and DBMI.

A nationally recognized leader in patient-derived tumor organoids and functional precision oncology has arrived at CU! Welcome, Alice Soragni, PhD (@alice.soragnilab.com) 👋 ⬇️
https://news.cuanschutz.edu/dbmi/alice-soragni-joins-university-colorado-anschutz

This is an interesting article for those beginning down the cryoEM route for structure determination from the perspective of a crystallography lab. Not giving up on crystallography yet 😜 but I honestly can't think of a single crystallography lab now that isn't also using CryoEM in some capacity.

Nature 🤝 Ornithology

.. who knew ..

www.nature.com/natcities/

This is 252 R01s, only. The math is quite devastating

This may end up being a hot take, but two things can be true at once: the new SciENcv is a pain, and it won't really affect things too much as most reviewers (...check notes...) actually use google/google scholar/REPORTER already

Maybe, and just maybe and controversially so, this buys into the concept that, by and large, reviewers will use google or google scholar + reporter, so why bother?? Obviously not a fan either, but there is the reality of what people actually do when reviewing applications that is of some comfort

Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13

😱 and quick!

Thanks!!

Congrats to all the authors! #ARTNetPublication

For me, that has meant quietly stepping back from collaborations that, from the outside, looked hard to walk away from. There is always more behind these decisions, and protecting trainees first and foremost, and then the integrity of our science is paramount

Of so many things to be infuriated about, this is perhaps my biggest gripe. Pancreatic cancer patients, who face a future without hope, are being denied a potential game-changing therapy
www.mskcc.org/news/can-mrn...

Proud of this review on centering models and next gen techs to address and prevent acquired resistance in cancer. Cements the work that our working group within @nciartnet.org has done over the last couple years, glad it resonated with people

sunset in LA: blue, red, pink, yellow gradient sky on a dark city scape

This city has a way

an elderly woman says it 's been 84 years ... ALT: an elderly woman says it 's been 84 years ...

But also, SENIOR ??!? I have not been gone that long 😂😂 (I know what you mean, just jk lol)

It has been a turbolent year on so many levels..very glad to be back

Thanks!!

Thank you Genevieve, so appreciate you and ill see you in the fall anyhow!

Thanks so much :D