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Charles Vaske

@seavaske.com

Genomics, bioinformatics, diagnostics, cancer, housing, and transit. Слава Україні https://orcid.org/0000-0001-8151-6612

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21.06.2023
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Latest posts by Charles Vaske @seavaske.com

Most cloud infrastructure engineering amounts to this, but is a bit less fun

05.03.2026 03:29 👍 4 🔁 1 💬 0 📌 0
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Zone 2 cardio. Mobility maxxing. There will be no further discussion.

05.03.2026 03:01 👍 284 🔁 70 💬 9 📌 9

We are not ready for Claudewitz

05.03.2026 03:03 👍 15 🔁 3 💬 0 📌 2

I'm open to Yee when the pool is so uninspiring, but Yee's stance on weak housing stances are untenable. California is pricing out so many people with lower incomes, and that's the core financial flaw of the state. If she could adopt Mamdani's policies I'd be a lot happier.

04.03.2026 04:56 👍 0 🔁 0 💬 1 📌 0
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Epistasis and co-adaptation in bacterial genome evolution - Nature Reviews Genetics Bacterial genome evolution is shaped by epistasis, which can constrain or promote specific evolutionary paths. The authors review how integrating the effects of epistatic interactions into population-...

Epistasis and co-adaptation in bacterial genome evolution www.nature.com/articles/s41... #epistasis #microbiology #evolution #genomics

03.03.2026 18:08 👍 4 🔁 1 💬 0 📌 0

You can always tell when Russia is scared about the status of their genocidal invasion, because they activate ludicrously false propaganda pushes in US media.

Russian lines are breaking for the first time in a long while, so Foreign Affairs is publishing Michael Desch carrying water for Putin.

26.02.2026 19:16 👍 0 🔁 0 💬 0 📌 0
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Realised I can display live posts on the map
bluesky-map.theo.io?live=1

(there's also an option under the settings cog to display post text, in case you really want to be overstimulated)

25.02.2026 20:04 👍 165 🔁 38 💬 20 📌 16
Alfred, Igor, and Mark on a stage at a rally for Ukraine in San Francisco. Igor is at the mic. There are US and Ukrainian flags in the background

Alfred, Igor, and Mark on a stage at a rally for Ukraine in San Francisco. Igor is at the mic. There are US and Ukrainian flags in the background

A large crowd marches down a wide sidewalk in San Francisco, holding Ukrainian flags and signs

A large crowd marches down a wide sidewalk in San Francisco, holding Ukrainian flags and signs

Several hundred turned out for today's Bay Area rally for continued support of Ukraine's fight for freedom and survival!

Berkeley councilmember @igortregub.bsky.social led the march, councilmember @markhumbert.bsky.social was also at the rally. ✊💙💛🇺🇦

23.02.2026 05:44 👍 54 🔁 5 💬 3 📌 0

Thanks so much for showing up, Alfred! So many that wanted to be there are unable to show up in an age when refugees with proper legal status are still being detained and deported.

23.02.2026 05:47 👍 2 🔁 0 💬 0 📌 0

Things are changing fast, turns out that the conservatives think the Chamber is now a "left-wing, open borders supporting activist group" bsky.app/profile/jose...

19.02.2026 18:35 👍 1 🔁 0 💬 0 📌 0

“Asked how the cuts have affected science, one [researcher] said, ‘This is like asking, how do you think dropping an atomic bomb on New York City will affect the future of Broadway musicals? This is a generational loss of innovation, technology, and economic power.’” 🔗 archive.ph/2026.02.12-1...

15.02.2026 21:46 👍 286 🔁 144 💬 3 📌 4
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‘My duty is to call it out’: Judge accuses Trump administration of discrimination against minorities The Reagan-appointed judge ordered the NIH to restore funds for research related to racial minorities and LGBTQ+ people.

They give away the game when they make up a straw man of people thinking "it's a sin to be white" because when they get power their intention is to make it a sin to *not* be white, or Christian, or whatever.

Even Reagan judges call it out: www.politico.com/news/2025/06...

08.02.2026 21:11 👍 1 🔁 0 💬 0 📌 0

Person A: It's unfair that you are paying far less in taxes than me for an identical home.

Person B: But have you considered that I hadn't been underpaying for just one year, but many years?

08.02.2026 17:01 👍 4 🔁 0 💬 1 📌 0

Science takes a village. Thanks to everyone who has mentored a scientist, and all those awesome mentees.

05.02.2026 18:02 👍 2 🔁 2 💬 0 📌 0

Indeed, my only surprise is that in silico tools would drive the drug program. I've always seen new structure data be combined with these tools.

05.02.2026 04:55 👍 0 🔁 0 💬 1 📌 0

Really? That's great to hear. Do you mean the protein structure alone, or pose estimates? Though I've seen pose estimation and binding affinity prediction (Boltz) used for guiding screens, I hadn't heard of individual predictions being strong enough.

05.02.2026 03:24 👍 0 🔁 0 💬 1 📌 0

I see a lot more crystal structures and cryoEM experiments to validate the shaky hypotheses that AlphaFold-alikes generate. Nobody is launching a new small molecule drug program on the basis of AlphaFold results, but they may do a ton of physical experiments because of them.

05.02.2026 03:12 👍 1 🔁 1 💬 1 📌 0

Almost no one does, which is why we are in this mess. The documentation in the Epstein emails is a good chance for us figuring out why Ukraine needs to win, but every day here is filled with so much corruption and tyranny that it's hard for the story to break through.

04.02.2026 18:47 👍 2 🔁 0 💬 1 📌 0
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Pursued by federal agents, suburban ICE observers remain resolved After a frightening pursuit by federal agents, suburban ICE observers say fear hasn’t stopped them from protecting their communities.

Suburban observers say ICE has only been more aggressive since Homan: “I think they’re getting angry that we’re winning and the country is rallying around us. We’re so organized and we act with such integrity. They don’t want to admit they feel threatened by us.”
share.google/ei9giIFLsuEJ...

04.02.2026 15:34 👍 1633 🔁 502 💬 7 📌 21

Trump walks out to journalists and says that Putin promised not to strike “Kyiv or other cities” for a week.

At the same time, russia is bombing several Ukrainian cities.
An apartment building is on fire in Kyiv right now. Explosions shake Kharkiv.

03.02.2026 00:38 👍 392 🔁 122 💬 16 📌 6
Tuberculosis Resurgence  A Growing Threat
Tuberculosis Resurgence A Growing Threat YouTube video by American Society for Microbiology

Despite being curable, tuberculosis remains one of the world’s deadliest infectious diseases—and it’s making a comeback. Explore the factors driving the TB resurgence. Addressing TB isn’t just about treatment—it’s about recognizing the warning signs before it's too late. youtu.be/QNslmoWEdqo

02.02.2026 23:55 👍 8 🔁 4 💬 0 📌 0

The most surprising thing to me is that Bundy actually held his stated principles rather than the unspoken ideology of all the people around him. Those of us observing from afar could see clearly what those people actually wanted, why didn't Bundy from up close?

02.02.2026 18:32 👍 0 🔁 0 💬 0 📌 0

Trump got rid of all common cents.

02.02.2026 07:15 👍 0 🔁 0 💬 1 📌 0

I'd love to have it prioritized on food labels, top level as with other macronutrients.

But most of the good sources are on things without food labels, like vegetables, bulk legumes, and whole grains.

Trying to hit 35g/day of fiber in a US diet requires conscious effort.

01.02.2026 20:19 👍 1 🔁 0 💬 0 📌 0

Where are the other two people that Alex Pretti was helping? Hopefully safe, and outside of the hands of ICE? I haven't seen any news about them.

How long must this brave woman hide before she's safe going to her home and being in public again?

01.02.2026 19:05 👍 1 🔁 0 💬 0 📌 0

Is there an existing wiki-on-demand services like there are for blogs?

Commercial offerings like Confluence are a bit hard to scale.

01.02.2026 17:33 👍 0 🔁 0 💬 0 📌 0

Max has been providing consistently important reporting on the state of science and the scientific workforce under the Trump administration. It's hard to see this as anything other than a reprisal for coverage that has been factual (not flattering).

31.01.2026 03:30 👍 37 🔁 13 💬 0 📌 0

Sounds like they tired to keep it secret but made a mistake in the table?

30.01.2026 18:26 👍 2 🔁 0 💬 0 📌 0

State murder charges are still there, the big news is that NY doesn't have the death penalty like the Feds do. Headlines are trying to deceive on this one...

30.01.2026 15:49 👍 10 🔁 0 💬 1 📌 0

The Bloomberg headline for this tricked me into clicking the article; good for generating one-time clicks but the reputational damage is big enough that I don't think I'll renew next month.

30.01.2026 15:43 👍 3 🔁 0 💬 0 📌 0