🎯Feature Alert 🚨
This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about

👉 WHERE molecules bind
👉 HOW FAST
👉 and in WHICH SEQUENCE

🔗 doi.org/10.1016/j.dr...

#allostery #pharmacology #DrugDesign #GPCRs

🚀 Time-dependent #ligand-receptor #BindingKinetics and functionality in a #heterodimeric receptor model by Ortiz et al. (2024): Predicting how 2 drugs bind to a receptor complex over time - with implications for combination-therapies and #DrugDesign💊

🔗 doi.org/10.1016/j.bc...

#Pharmacology #GPCRs

📖 Just published 💊

👉 Introducing a rigorous theoretical framework for better #quantification of #drug-target #ResidenceTime (RT) - a key metric in #BindingKinetics that has lacked a firm quantitative foundation to date 👏

🔗 www.sciencedirect.com/science/arti...

#Pharmacology #ComputationalBiology

🧠 Ever wondered what affects how #morphine works in the brain? This modelling study found #beta-endorphin to be a major player in how morphine occupies its µ-opioid receptors (MORs) in rat #hypothalamus 🐭

#EndogenousOpioids matter, folks!
#BindingKinetics #MOR

www.sciencedirect.com/science/arti...