Scientists identify #CDK7 as a critical vulnerability in #HNSCC, showing that inhibition of CDK7 suppresses #tumor growth, highlighting CDK7 as a promising therapeutic target for clinical translation. @universidadoviedo.bsky.social

#FeaturedArticle #STTT: doi.org/10.1038/s413...

Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells
Laki Buluwela @simak.bsky.social @bjgreber.bsky.social et al find a single base change of #CDK7 conferring resistance to non-covalent CDK inhibition in prostate cancer
www.embopress.org/doi/full/10....

Blocking CDK7 attenuates inflammatory arthritis - Nature Reviews Rheumatology In a new study, inhibition of CDK7 disrupted the RNA polymerase II transcription cycle, leading to anti-inflammatory effects and metabolic reprogramming in macrophages and attenuation of arthritis in ...

@natrevrheumatol.bsky.social just did a write-up about our #CDK7 work! www.nature.com/articles/s41... published in Science Translational Medicine last month