Researchers identify CDC20, DTL, & RRM2 as #AR‑independent drivers of advanced #ProstateCancer via RB1/E2F1, with novel inhibitors surpassing AR antagonists, offering new #CastrationResistant targets & a #bioinformatics‑driven discovery paradigm.

#OpenAccess: doi.org/10.1016/j.ge...

This review highlights how #ferroptosis—offers promise for #CastrationResistant #ProstateCancer, outlining its regulatory networks, emerging combination strategies, #biomarker-driven precision approaches, and hurdles to clinical translation.

#OpenAccess: doi.org/10.1016/j.ge...

Histone methyltransferase KMT2D targets the SPOP-G3BP1 axis to enhance AR stability and drive castration-resistant prostate cancer progression - Molecular Biomedicine Castration-resistant prostate cancer (CRPC) poses a significant clinical challenge, characterized by limited therapeutic options and unfavorable prognosis, particularly among elderly men. Reactivation...

#Research
Histone methyltransferase KMT2D targets the SPOP-G3BP1 axis to enhance AR stability and drive castration-resistant prostate cancer progression doi.org/10.1186/s435...

#AndrogenReceptor #CastrationResistant #Methylation #Signaling #Ubiquitination

March is #ProstateCancerAwarenessMonth in the UK📣

Omid Yazdanpanah, MD explores the potential of #radioligandtherapy combined with #androgen receptor pathway inhibitors (ARPIs) for #metastatic #castrationresistant #prostatecancer (mCRPC)🔬

👉 buff.ly/q8aQ75D