Single-cell multiome and enhancer connectome of human retinal pigment epithelium and choroid nominate causal variants in macular degeneration - PubMed Age-related macular degeneration (AMD) is a leading cause of vision loss worldwide. Genome-wide association studies (GWASs) of AMD have identified dozens of risk loci that may house disease targets.…

New Cell Reports study moves GWAS from association to causation, using single-cell multiomics to pinpoint causal variants driving macular degeneration.
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