A mouse model of Nose bleeding
#HereditaryHemorrhagicTelangiectasia
Bmx+ Endothelial Cell ALK1 KO🐭
+🧠microhemorrhage
Arterial tortuosity, ectasia
Arteriolar smooth muscle cell wrapping defects
⏬pial/mesenteric arterial tone
@mfnavedo.bsky.social #CircRes 2026
www.ahajournals.org/doi/10.1161/...
FGF13 Cardiomyocyte Conduction
Cardiomyocyte Fgf13 KO🐭
👉Sensitive to Cx43 gap junction blocker
⏫QRS duration
⏫Conduction block
⏬Conduction velocity
👉Perturbed Cx43 localization
TurboID FGF13 interactome▶️
FGF13 stabilizes Microtubule
⏫α/β-tubulin
#CircRes 2025
www.ahajournals.org/doi/suppl/10...
#TissueEngineeredVascularGraft
#hiPSC #SmoothMuscleCell on 3-mm PGA tubular scaffold
Decellularized
Rupture pres 1200 mmHg
Suture retent str 120 g
Re-endothelialized⏩rat aortic graft 30 d
❎thrombus
Repop by host EC
#CircRes 2022 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
#SmoothMuscleCell #Piezo1 #Hypertension
#HydrostaticPressure➡️
⏫GPR146➡️
⏫SMC synthetic phenotype
⏫cAMP-CREB-Piezo1➡️⏫Syst/Diastolic Blood Pressure
Evidence from GPR146 KO
SMC-GPR146 KI & KO
AAV2-SM22a-GPR146 +SMC-Piezo1 KO🐭
#CircRes 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
VEGFA/VEGFR2/3➡️Rac1-RhoA/ROCK antagonism➡️⏫ #LymphaticEndothelialCell Barrier function in intestinal lacteal capillaries
A discontinuous button-like to continuous zipper-like junctional shift
⏫barrier to chylomicron uptake
#CircRes 2023 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
Obstructive Sleep Apnea and Cardiometabolic Disease: Obesity, Hypertension, and Diabetes.
www.ahajournals.org/doi/10.1161/...
@ahajournals.bsky.social
#CardioSky #OSA #CircRes
Attending #BCVS2025? Meet #AHAJournals Editors from #CircGen, #CircRes, and #JAHA, and learn more about getting your work published. #cardiosky
Stop by the #AHAJournals booth on Thursday during the pm break and get your questions answered!
📅 July 24
🕔2:45-3:15pm
📍#AHAJournals booth
Exercise Training in Heart Failure: Clinical Benefits and Mechanisms.
www.ahajournals.org/doi/10.1161/...
@ahajournals.bsky.social
#CardioSky #CircRes #HeartFailure
🧬 New immunotherapy for atherosclerosis @ahajournals.bsky.social #CircRes
Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles.
🔗 doi.org/10.1161/CIRC...
#Immunotherapy #Atherosclerosis #Nanomedicine
#CNIC_CARDIO #immunosky #cardiosky
Pharmacogenomics and Pharmacokinetics of Aspirin in Preeclampsia Prevention.
www.ahajournals.org/doi/full/10....
@ahajournals.bsky.social
#CardioSky #MedSky #CircRes #Preeclampsia #Aspirin
Note that #EndothelialCell miR-15a/16-1 KO has similar cerebrovascular benefits - Angiogenesis & BBB
#CircRes 2020
www.ahajournals.org/doi/10.1161/...
#SciSignal 2020
www.science.org/doi/10.1126/...
Novel Mouse Model of Coronary Atherosclerosis With Myocardial Infarction: Insights Into Human CAD.
www.ahajournals.org/doi/10.1161/...
@ahajournals.bsky.social
#CardioSky #MedSky #Cardiology #MI #CAD #CircRes
The Lymphatic Vasculature in Cardiac Development & Ischemic Heart Disease
#Lymphoangiocrine #Reelin▶️#Integrinβ1 #Cardiomyocyte
🫀development & regeneration post-cryoinjury/-MI
@lforlymphatics.bsky.social @lymphaticsprox1.bsky.social #CircRes 2023
www.ahajournals.org/doi/10.1161/...
Decoding the Liver-Heart Axis in Cardiometabolic Diseases.
www.ahajournals.org/doi/10.1161/...
#CardioSky #MedSky #CircRes
KDIGO (Kidney Disease Improving Global Outcomes) classification of chronic kidney disease (CKD) from the 2024 KDIGO guidelines
Renal-Cardiac Crosstalk in the Pathogenesis and Progression of Heart Failure.
www.ahajournals.org/doi/10.1161/...
@ahajournals.bsky.social @kdigo.org
#CardioSky #MedSky #CircRes #HeartFailure #CKD
Understanding Thoracic Aortic Disease in Women
♀️➡️3-fold⏫risk of Dissection/Rupture of aneurysmal aortas
♀️➡️40% more likely aortic death
Estrogen
#VascularAging
#ArterialStiffness
Pregnancy & TAD
#AortaEd
#CircRes 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
Cardiac Fibrosis in the Multi-Omics Era: Implications for Heart Failure.
www.ahajournals.org/doi/10.1161/...
@ahascience.bsky.social @ahajournals.bsky.social
#CardioSky #MedSky #CircRes #HeartFailure
Advances in Our Understanding of Cardiovascular Diseases After Preeclampsia.
www.ahajournals.org/doi/10.1161/...
@ahajournals.bsky.social @ahascience.bsky.social
#CardioSky #MedSky #AHAJournals #CircRes #CardioObstetrics
Preservation of Vascular Endothelial Function in Late-Onset Postmenopausal Women.
www.ahajournals.org/doi/full/10....
@ahajournals.bsky.social
#CardioSky #MedSky #AHAJournals #CircRes
Oldie but Goldie. I discovered that #CircRes @ahajournals.bsky.social mentioned our Rgs5 story on their podcast -> circresearch.libsyn.com/may-2024-dis... How cool is that?! Thanks so much :)In case you missed it: www.ahajournals.org/doi/10.1161/...
@sfb1531.bsky.social @instcardregffm.bsky.social
Our editorial "Fiber, Fatty Acids, and Blood Pressure: A Gut-Level Solution is now published in #CircRes @ahajournals.bsky.social 👇
www.ahajournals.org/doi/10.1161/...
Highlighting a fantastic paper by @fzmarques.bsky.social 👇
www.ahajournals.org/doi/10.1161/...
Interesting breakdown by @fzmarques.bluesky.social & @rikeish.bsky.social on how the gut #microbiome shapes #bloodpressure of their paper published in #CircRes.
📝 Blog: www.marqueslab.com/post/underst…
📄 Paper: www.ahajournals.org/doi/10.1161/���
#Hypertension @ahajournals.bsky.social
🎉 Huge thanks to #CircRes @ahajournals.bsky.social outstanding reviewers, including former #KiraboLab former trainee @ashleylpitzer, now Assistant Professor #MeharryMedical #MeharrySOGS! Your commitment to scientific excellence continues to shine. #ProudMentor #WomenInSTEM
Honored to contribute to this important review on Epigenetic Regulation of Innate & Adaptive Immune Cells in Salt-Sensitive Hypertension, published in #CircRes
Huge congrats to 1st author Ashley for leading this!
Read it here: ahajrnls.org/40EUrMY
#Hypertension #Epigenetics #ImmuneRegulation
#HemeMetabolism #Bilirubin #Atherosclerosis
Global Blvra/Biliverdin Reductase α KO in Apoe-/-🐭➡️
Bilirubin depletion
⏫Plasma/Arterial Cholesterol
⏫#PlaqueInstability (intraplaque hemorrhage, neutrophil infiltration)
#CircRes 2023 @ahascience.bsky.social
www.ahajournals.org/doi/full/10....
Call for Submissions:
Circulation Research invites submission of Research Letters to accompany an upcoming Compendium on “Interorgan Crosstalk in #HeartFailure & #Cardiometabolic Diseases”. Details here: bit.ly/3AY9W8Y
Submissions due by January 24, 2025 #cardiosky #CircRes
#LaminarShearStress-KLF2 in #EndothelialCell ⏬BMP signaling ▶️⏬#VascularCalcification in hyperlipidemic🐭
BMP4 BMPER as direct targets of KLF2
LSS
⏫BMPER
⏬BMP4 MGP FST
OsteoSense 680 to image aortic calcification in vivo
#CircRes 2021 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
Vangl2 #PlanarCellPolarity in Coronary vascularization🫀
Vangl2 lp/lp🐭
1⃣Ectopic, dilated, tortuous coronary vessels e13.5 ~18.5
2⃣⏬epicardial EMT/inward migration e14.5
3⃣Thinned #SmoothMuscleCell coverage of intramyocardial coronary arteries
#CircRes 2008
www.ahajournals.org/doi/10.1161/...
