Map DNA methylation at single-base resolution across the whole genome with Novogene WGBS/EM-Seq. Detect 5mC, 5hmC and epigenetic changes with high coverage and library quality. #Epigenomics #Methylation #WGS #DNAmodifications https://bit.ly/401Wn1X

Direct detection of 8-oxo-dG using nanopore sequencing - Nature Communications Oxidative DNA damage is linked to cancer and aging, but its genomic effects remain hard to map. Here, authors develop a nanopore-based method using synthetic DNA and deep learning to detect 8-…

Direct detection of 8-oxo-dG using nanopore sequencing. #DNAmodifications #Nanopore #Sequencing ‪@natcomms.nature.com‬
www.nature.com/articles/s41...

Uncalled4 improves nanopore DNA and RNA modification detection via fast and accurate signal alignment - Nature Methods Uncalled4 is a toolkit for nanopore signal alignment, analysis and visualization allowing for performant detection and analysis of DNA and RNA modifications.

Uncalled4 improves nanopore DNA and RNA modification detection via fast and accurate signal alignment. #DNAmodifications @nanoporetech.com #Sequencing #Bioinformatics @naturemethods.bsky.social 🧬🖥️
www.nature.com/articles/s41...

#research #DNAmodifications

Zwitterionic DNA: enzymatic synthesis of hypermodified DNA bearing four different cationic substituents at all four nucleobases (Kuprikova, @hoceklab.bsky.social) - @narjournal.bsky.social: doi.org/10.1093/nar/...

@iocbprague.bsky.social @akademievedcr.bsky.social

Figure 1 in Erdmann Dougherty et al. (2025): "Analysis of Erwinia phages Vettismorki and Gravdalen. (A) TEM imaging of Erwinia phage Vettismorki, tail contracted. (B) TEM imaging of Erwinia phage Gravdalen, tail non-contracted and tail fiber visible. (C) Whole-genome nucleotide similarity of Vettismorki and Gravdalen in comparison with select related phage genomes (VIRIDIC). (D) Bootstrapped maximum likelihood tree of large terminase subunit acid alignments with select related phages. (E) clinker figure showing amino-acid similarities between protein-coding sequences of select related phages. Protein clusters with > 30% sequence identity are coloured with the same colour."

New publication: Novel #bacteriophages targeting wheat #phyllosphere bacteria carry #DNAmodifications and single-strand breaks, by @raaijmakersjm.bsky.social and others. #genomics #biodiversity