De novo design of synthetic microbial genomes - Nature Reviews Bioengineering Synthetic biology might enable the bottom-up construction of synthetic genomes, offering a foundation for building synthetic cells. This Review discusses strategies for rational genome design, genome-...

Review: De novo design of synthetic microbial genomes in Nature Reviews Bioengineering

It describes the factors to be considered in the rational design of a synthetic genome as well as the techniques that can support this effort
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