#SmoothMuscleCell #Aging Mechanobiology

24- vs 4-mo rat SkM feed artery

Aged SMC
👉RNAseq ⏬Contractile gene #FocalAdhesion
👉Faster kinetics⏫αSMA filament ⏫vinculin cluster to #CyclicStretch
👉Pressure Inert on 4 kPa matrix; Sensitive on 100 kPa

#FrontPhysiol 2025
www.frontiersin.org/journals/phy...

Frontiers | Comprehensive analysis of risk factors and metabolic profiling in preclinical atherosclerosis: a cross-sectional study AimThis study aimed to explore the factors influencing preclinical atherosclerosis (PCA) and provide evidence-based recommendations for its prevention. Non-t...

Comprehensive analysis of risk factors and metabolic profiling in preclinical atherosclerosis: a cross-sectional study #FrontPhysiol #MassSpec www.frontiersin.org/journals/phy...

Frontiers | Analysis of neuronal cardiolipin and monolysocardiolipin from biological samples with cyclic ion mobility mass spectrometry The mitochondrial phospholipid cardiolipin (CL) is essential for proper mitochondrial function and energy production. Cardiolipin has four distinct fatty aci...

Analysis of neuronal cardiolipin and monolysocardiolipin from biological samples with cyclic ion mobility mass spectrometry #FrontPhysiol www.frontiersin.org/journals/phy...

Coronary arterial #SmoothMuscleCell #Senescence (Replicative Bleomycin)

#Proteomics LC-MS➡️1083 Differentially expressed proteins in replicative senescence
7- vs 1-wk passaging
p16/p21 proteins Unaltered🥸

#FrontPhysiol 2020
www.frontiersin.org/journals/phy...

Understanding the roles of salt-inducible kinases in cardiometabolic disease

Isoform-specific & redundant roles of SIK1/2/3

Interplay with cAMP-PKA-CRTC/CREB; Ca2+-CAMKI-PP2A-Na+/K+ ATPase; Class IIa HDAC-MEF2; TGFβ-SMAD7 cascades

#FrontPhysiol 2024
www.frontiersin.org/journals/phy...

Hyperglycemia-YAP cascade in diabetic #VascularInflammation, likely both arterial #EndothelialCell & #SmoothMuscleCell

db/db mice

This time, TAZ seems not to be responding to #HighGlucose/#DisturbedFlow

Marco Meloni lab #FrontPhysiol 2021
www.frontiersin.org/journals/phy...

Global KO of Sigmar1🐭, a pleotropic chaperone protein,▶️#EndothelialCell & #SmoothMuscleCell dysfunction

⏫#ArterialStiffness
eNOS deficiency
⏬FMD
SMC disarray
Aortic Fibrosis
Mitochondrial elongation
⏬Mitochondrial respiration

#FrontPhysiol 2024
www.frontiersin.org/journals/phy...