Individual genetic differences render some antibody-based therapies ineffective – BioNews Central Individual genetic differences can cause antibody-based therapies to be ineffective in some people. ...

Individual #GeneticDifferences can cause #AntibodyBasedTherapies to be ineffective in some people. 
#AntibodyTherapies #GeneticVariation #TherapyResistance

Texas Children’s/Baylor researchers developed new tool to improve accuracy of genetic testing The tool offers a new way to measure genetic variants in the Genome Aggregation Database (gnomAD), one of the world’s most widely used resources for understanding human genetics.

Researchers can now divide the #genome into #ancestry-specific segments for more accurate insights into #geneticDifferences. @egatkinson.bsky.social @pragskore.bsky.social M. Wilson et al @bcmhouston.bsky.social @bcmgenetics.bsky.social @natcomms.nature.com blogs.bcm.edu/2025/10/07/f...

Over 140 mutations in CTNS are linked to #cystinosis, with severe mutations causing infantile (nephropathic) forms.

Interpretation: Scientists see tons of #geneticdifferences cause cystinosis: bigger changes = a more severe form.

 Source: American Journal of Physiology-Renal Physiology, 🔗 in bio.

Eastern gray squirrel

Eastern gray squirrel with melanism, a gene mutation causing solid black fur.

These squirrels are both Eastern gray squirrels. An uncommon gene mutation causes the black fur. In some areas the mutation only occurs once/10,000. They enjoy some like being less visible to predators and more visible to cars. #nature #squirrels #geneticdifferences #biodiversity #365species