Catching up with the Pflum Lab: "Thermal shift engagement assay for Class IIA histone deacetylase inhibitor screening" in the journal Results in Chemistry. #wsuchemistry #chembio #HDAC #ChemSky

All Authors: Lauren N. Kotsull, and Mary Kay H. Pflum

doi.org/10.1016/j.re...

In the journal Horticulture Research, by combining genetic, biochemical, and multi-omics approaches, the team investigated how epigenetic regulators influence resistance to downy mildew in Brassica rapa.
#HDAC #Downy mildew resistance
Details: doi.org/10.1093/hr/u...

"Unlike class I HDACs, HDAC6-mediated regulation in these studies was directed at sarcomere protein deacetylation [54] or tubulin hyperacetylation [55], which suggests that the class IIb HDAC, HDAC6 regulates cardiac function through non-epigenetic mechanisms."

#HDAC #tubilin #microtubules

Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure [2018]
www.mdpi.com/2072-6643/10...

#NaturalProducts #FunctionalFoods #HeartFailure #HDAC

Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition In models of chronic migraine, neuronal complexity is diminished in head-pain processing regions but restored through HDAC6 inhibition, which increases tubulin acetylation and cytoskeletal flexibility...

Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition [2021]
elifesciences.org/articles/63076

"... HDAC6 inhibitors could attenuate CSD is through increased tubulin acetylation, thus counteracting microtubule disassembly... "

#migraine #HDAC

HDAC11 Deacetylates BRAF to Regulate Kinase Activity and Cell Proliferation Histone acetylation, governed by histone deacetylase (HDAC) enzymes, plays a pivotal role in cell biology. Elevated HDAC expression is linked to a poor prognosis in various diseases, including cancer, making HDAC inhibitors clinically valuable. Among the 11 metal-dependent HDAC isoforms, the exceptional ability of HDAC11 to regulate both the deacetylation and defattyacylation of proteins suggests an expansive role in cellular processes. However, since HDAC11 is one of the least studied HDAC isoforms, the known roles for HDAC11 in cell biology are limited. In this study, proteomics-based mutant trapping was performed to identify nonhistone substrates of HDAC11 and link HDAC11 activity to specific cellular events. Proteomics revealed 64 putative substrates, with follow-up studies documenting that HDAC11 deacetylates the BRAF kinase on K680 to suppress kinase activity and cell proliferation. Given the established role of BRAF in cancer, HDAC11-mediated deacetylation likely influences signaling pathways in tumor progression, underscoring the diverse regulatory role of HDAC11 in cellular events.

🚨 PUBLICATION ALERT 🚨

From the Pflum Lab, “HDAC11 Deacetylates BRAF to Regulate Kinase Activity and Cell Proliferation” in ACS Chemical Biology. #wsuchemistry #chembio #ChemSky #HDAC

doi.org/10.1021/acsc...

Lauren Kotsull’s PhD research has been published! This project represents years of hard work, creativity, and collaboration in research in the Pflum Lab at #wsuchemistry. Congrats, Lauren! #chembio #HDAC #chemistryindetroit #ChemSky

doi.org/10.1016/j.re...

Class IIa HDACs forced degradation allows resensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer

➡️ buff.ly/SZQZJaL

#HDAC #Oxaliplatin #CRCSM

This study shows that purinostat mesylate, a #HDAC inhibitor, has good efficacy & immune-modulating effects in #MultipleMyeloma & #lymphoma, highlighting its potential as an effective therapy for #HematologicMalignancies. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Engineering a Cool Revolution: Shumate’s Hybrid-Dry Adiabatic Design Tackles AI-Era Density As AI drives data center density to new extremes, Shumate Engineering unveils a game-changing hybrid cooling design. In this episode of the DCF Show podcast, Daren Shumate and...

🎧 New on the DCF Show #Podcast: Shumate Engineering’s #HDAC system combines closed-loop dry cooling + targeted adiabatic assist. #PUE ≈ 1.05, #WUE 0.07, 90% less water, 50% less power than chillers—scalable + retrofit-ready.
Listen: www.datacenterfrontier.com/podcast/arti...
#AICooling #DataCenters

· Proteomics services for accurate identification and quantification of lactylation modifications.
#Ferroptosis #Lactylation #CustomAntibody #Proteomics #ColorectalCancer #LiverTransplantation #HDAC #PTM

Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11 Histone deacetylase (HDAC) enzymes are epigenetic regulators that affect diverse protein function by removing acyl groups from lysine side chains throughout the proteome. The most recently discovered ...

Very happy to see this story out in #JACS_Au!

Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11
pubs.acs.org/doi/10.1021/...

#ChemBio #chemsky #HDAC

X-Box-Binding Protein 1 Activates Lytic Epstein-Barr Virus Gene Expression in Combination with Protein Kinase D Epstein-Barr virus (EBV) establishes a latent form of infection in memory B cells, while antibody-secreting plasma cells often harbor the lytic form of infection. The switch between latent and lytic E...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"In this work, we demonstrate that the combination of the active (spliced) form of #XBP1 (XBP-1s) with activated protein kinase D ( #PKD, a histone deacetylase [ #HDAC] inhibitor that is activated following antigen receptor engagement in B cells)"

Histone deacetylases: Regulation of vascular homeostasis via endothelial cells and vascular smooth muscle cells and the role in vascular pathogenesis

A review on the physiological & pathological role of HDACs in regulating vascular homeostasis & vascular diseases, respectively, with a discussion on the therapeutic effect of #HDAC inhibitors on #VascularDiseases. #Epigenetics

#OpenAccess : https://buff.ly/3PNGaaF

Kickstart Your Microsoft Fabric Journey: A Comprehensive Introduction in Hindi YouTube video by Learn Microsoft Fabric, Power BI, SQL Amit Chandak

𝗦𝘂𝗽𝗲𝗿 𝗦𝗮𝘁𝘂𝗿𝗱𝗮𝘆! Jan 𝟮𝟱, 𝟮𝟬𝟮𝟱:
Topic: Kickstart Your Microsoft Fabric Journey (Hindi)
Time: 9:00 AM IST onward
Watch- youtube.com/live/CHzWfDf...
𝗜𝗻-𝗣𝗲𝗿𝘀𝗼𝗻(𝗛𝗗𝗔𝗖 𝗠𝗲𝗲𝘁𝘂𝗽)
Why Should I Consider a Career in Microsoft Fabric?
Venue: Draper Startup House, Hyderabad
4:00 PM IST onward
#MicrosoftFabric #HDAC

Multicomponent syntheses enable the discovery of novel quisinostat-derived chemotypes as histone deacetylase inhibitors In this study, we synthesized and evaluated novel histone deacetylase (HDAC) inhibitors derived from the clinical candidate quisinostat. A library of …

Since #chemsky is really taking off now, I am very happy to share our new paper on the multicomponent synthesis of quisinostat analogs as antiplasmodial and anticancer #HDAC inhibitors. Thanks to everyone involved in this project!

www.sciencedirect.com/science/arti...

Remodeling of retrotransposon elements during epigenetic ... Background The capacity for plasticity in the adult brain...

Paper on removing molecular brakes that limit adult visual cortical plasticity http://www.epigeneticsandchromatin.com/content/8/1/55 #HDAC inhibitors