Artios Reports Randomized Phase 2a Study of Low Dose Alnodesertib Plus Gemcitabine Achieves Primary Endpoint in Platinum-Resistant Ovarian Cancer - Artios Pharma Low dose alnodesertib plus gemcitabine met the primary endpoint of progression-free survival (PFS) versus gemcitabine alone in patients with platinum-resistant high-grade serous ovarian cancer Study p...

#ArtiosPharma #ovariancancer #PlatinumResistantOvarianCancer #oncology #GynaecologicalOncology #ovariancancermonth #Alnodesertib #Gemcitabine #biopharma #DDRmedicines #highgradeserousovariancarcinoma #HGSOC #ATRinhibitor #platinumresistantHGSOC #DDRpathways #DNAreplicationstress
zurl.co/XtxxD

FDA Grants Fast Track Designation for ETX-19477 in BRCA-Mutated, Platinum-Resistant HGSOC | OncLive FDA grants fast track designation to a PARG inhibitor, ETX-19477, for the treatment of BRCA-mutated, platinum-resistant HGSOC.

FDA Grants Fast Track Designation for ETX-19477 in BRCA-Mutated, Platinum-Resistant HGSOC #oncology #HGSOC
www.onclive.com/view/fda-gra...

Our paper in collaboration with Pam Kreeger, "Comparative proteomic analysis of the #ECM of the human omentum and mesentery, the main sites of #HGSOC metastasis", is now published in @cp-iscience.bsky.social!
You can read it in #openaccess at doi.org/10.1016/j.is...
🎊 Congrats to all co-authors!

Microscopy images of healthy omentum and omentum of an ovarian cancer patient showing increased collagen content in the diseased condition.

Excited to have contributed with James Considine from my lab to this exciting work from Pam Kreeger's lab that showed that fibronectin composition and TGM2 crosslinking cooperatively regulate #HGSOC cell adhesion. The paper is now out in Acta Biomaterialia! Have a look: doi.org/10.1016/j.ac...

Excited to share our recent work about the role of the molecular chaperone TRAP1 as RNA-binding protein! #RBPs #HGSOC

Adenosine-to-inosine editing of miR-200b-3p is associated with the progression of high-grade serous ovarian cancer

👉 buff.ly/FMrZvtO

#HGSOC #miR200 #RNAediting

Comparative proteomic analysis of the ECM composition of the human omentum and mesentery, the main sites of ovarian cancer metastasis Due to its limited symptoms, high-grade serous ovarian cancer (HGSOC) has frequently metastasized extensively throughout the peritoneal cavity prior to its diagnosis, resulting in an overall five-year...

In collaboration with Pam Kreeger's lab, we asked whether differences in the #ECM of the omentum and mesentery could explain the difference in prevalence of ovarian cancer metastasis to these sites. Read our preprint to learn what we found! #HGSOC #Matrisome www.biorxiv.org/content/10.1...

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

👉 buff.ly/4OGCRch

#HGSOC #Chemoresistance

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

👉 buff.ly/ikXlqbh

#ViralMimicry #Inflammation #HGSOC #Retroelements

🩸 Plasma-activated media selectively induces apoptotic death via an orchestrated oxidative stress pathway in high-grade serous ovarian cancer cells

👉 buff.ly/9W71sWg

🥼 @Nirmalrob

#OVCA #Apoptosis #HGSOC

Circulating extracellular vesicles protein expression for early prediction of platinum-resistance in high-grade serous ovarian cancer - PubMed Platinum resistance in high-grade serous ovarian carcinoma (HGSOC) portends a poor prognosis. Although initial platinum-based chemotherapy response rates are high, 15-20% of patients demonstrate…

Very interesting finding in circulating extracellular vesicles (EV) - an excellent correlation between FH and TMEM205 EV levels and Platinum resistance in high-grade serous ovarian carcinoma. #HGSOC #cancer #complement buff.ly/eFy0r2Q

Very excited for this one to hit the web NCI supported collaboration with @JBurdetteLab Hannah and Monicas work on branched aacrjournals.org/cancerrescom... branched chain amino acids in #HGSOC for the #MSImaging nerds lessons in ion suppression for studies using agar/agarose!