How can HiFi sequencing unlock deeper insights into cancer biology than short reads for gene fusions and isoforms?

Our new series shows how researchers use #PacBio to drive discoveries in methylation and structural variation.

Watch here: bit.ly/3P78pnA

#CancerResearch #HiFisequencing

1 month to go until #PacBioPRISM 2026 in Barcelona! Registration is now open, we’re excited to bring the #Genomics community together for learning, conversation & connection. <10% of spots left.

Register: bit.ly/412nkSE
#HiFiSequencing

Long-read genome sequencing improves detection and functional interpretation of structural and repeat variants in autism Mortazavi et al. investigated structural and tandem repeat variants from long-read WGS in a cohort of 267 individuals from 63 families affected by ASD. They detected de novo and complex DUP-DEL SVs, i...

A new paper in Cell Genomics validates how #PacBio HiFi sequencing unlocks ASD research.

By replacing multiple assays with one workflow, researchers saw a 33% increase in SV detection and a 38% increase in tandem repeat detection.

Read the study: bit.ly/4sAnkFd

#ASD #PacBio #HiFisequencing

One molecule. Multiple layers of biology.

HiFi sequencing = multiomic insights.

It reveals the genome, structural variants, full-length isoforms, and base-level methylation. All in one run. All from the same molecule.

Get the full picture: bit.ly/3YSPBdo

#PacBio #HiFisequencing #Multiomics

What happens when a condition shifts from rare to widespread?

In Episode 3 of Beyond the Bench, Dr. Birgitt Scheule explains what it means to shift from studying isolated cases to addressing disease at population scale.

Watch now: bit.ly/4oLrOXu

#BeyondTheBench #PacBio #HiFisequencing

Heading to ACMG 2026 in Baltimore?

Visit PacBio at booth #2321 to see how HiFi sequencing is redefining genetic testing. Learn about the Vega system and how to consolidate assays for rare disease and PGx research.

Full program here: bit.ly/3OBZmee

#ACMGMtg26 #PacBio #HiFisequencing #ACMG

Want epigenetic information automatically included in your sequencing runs?

HiFi sequencing detects 5mC and 6mA directly from native DNA and combines multiple passes of the same molecule to generate long reads with greater than 99.9% accuracy.

See how: bit.ly/3YSPBdo

#PacBio #HiFisequencing

Miami Biology professor featured in DNA sequencing video series Andor Kiss appears in PacBio's Beyond the Bench series discussing DNA sequencing technology

New from Miami University: Dr. @andorjkiss.bsky.social and his lab’s work featured in BEYOND THE BENCH.

Students are generating long-read sequencing data in-house and learning how sequencing strategy shapes discovery.

Read the story: bit.ly/4aFSgMS

#BeyondTheBench #PacBio #HiFisequencing

Repeat expansions and complex regions still challenge PCR and short reads.

See how labs use PureTarget with PCR-free HiFi sequencing of native DNA to build scalable custom panels and improve confidence across difficult loci.

Save your spot: bit.ly/3MElTWS

#PacBio #PureTarget #HiFisequencing

Happening this Thursday: learn how SPRQ-Nx chemistry on the Revio system supports scalable HiFi genomes and multiomic discovery at a lower cost.

Hear real-world data from early-access users and explore expanded methylation calling.

Register: bit.ly/4qLqV2Q

#PacBio #SPRQNx #HiFisequencing

Experts from GSK, Pfizer, AstraZeneca, and UCL share how PacBio HiFi sequencing is advancing #biopharma R&D, from AAV characterization to mRNA vaccine CQA and antibody screening.

Watch the teaser and access the full session on-demand: bit.ly/49BMHOY

#PacBio #HiFisequencing #DrugDiscovery

Meet some of our PacBio-compatible partners!

Hear from the team at #FOG2026 about how #HiFiSequencing pairs with complementary technologies to reveal hidden biology—and help tackle some of the most challenging genetic causes of #RareDisease.

Learn more: bit.ly/4mUyVMd

We have a WINNER! Thank you, Hanh H, for sharing your 'Magenta Moment' at FOG 2026. We hope you enjoy your Magenta Oodie. ❤️

#HiFiSequencing #FOG2026 #Genomics

When did you know it was time to switch to #HiFiSequencing?

Cristina Cotobal Martin (Wellcome Sanger Institute) + Mohammed Uddin (MBRU) share their turning point—“The quality has never been compromised.”

Meet us at #FOG2026. #TheresHiFiForThat

Hello #FOG2026! We love hearing how #HiFiSequencing supports key moments in your work—from breakthroughs to impact.

Let’s partner to support your research—stop by today. #TheresHiFiForThat

@sptlabtech.bsky.social @adameur.bsky.social

PacBio is at ExCeL London for FOG2026!📍 Booth 165
Come see HiFi long-read sequencing + #Revio up close.
Take part in Magenta Moments: wear magenta → snap a pic → post + tag PacBio + use #FOG2026 to enter.
🏆 Live prize draw: Jan 29, 1:00 PM @ Booth 165
Learn more: bit.ly/3MAm7y1
#HiFiSequencing

Clinical long-read genome sequencing for rare disease diagnostics Background Diagnostic evaluation of rare genetic disorders continues to rely on multiple test modalities, despite the increasing use of short-read exome or genome sequencing as first-tier tests. Long-...

A 1,000-sample Radboud study shows HiFi WGS can help replace multiple clinical tests while enabling an increase in diagnostic findings, pointing to clear evidence that long reads are on track for first-line use.

Ready the study here: bit.ly/4jUxEF9

#PacBio #HiFisequencing #ClinicalGenomics

A year in review: HiFi in the Headline - PacBio PacBio drove technical advances, expanded access to HiFi sequencing, and helped researchers answer some of genomics’ most important questions.

2025 was a milestone year for HiFi sequencing. 🧬✨

From clinical research advances to multiomics, ultra low input workflows, and large scale genomics, see how HiFi made headlines and what these breakthroughs are shaping next.

Read the full year in review: bit.ly/49qDsmb

#PacBio #HiFisequencing

GIVEAWAY at #FOG2026: join our Magenta Moments challenge 🩷
To enter: wear something magenta, snap a pic, and post on Bluesky using #FOG2026 + tag @PacBio.

🏆 Bonus prizes for the most creative magenta looks
⏰ Winners drawn LIVE: 29 Jan, 1 PM at our booth

Learn more: bit.ly/3MAm7y1
#HiFiSequencing

As 2026 begins, we celebrate our customers and the global genomics community. 🎆

In 2025, their work advanced human health, precision medicine, agriculture, complex genomes, and more. We’re honored to support these discoveries and look forward to what’s next!

#PacBio #HappyNewYear #HiFisequencing

From pipetting samples to managing data, every lab role has challenges. HiFi sequencing can make your work easier and your results more reliable.

Download the Seq 101 Guide to see how HiFi supports your lab, research, and role: bit.ly/4gGkp9t

#PacBio #ThereHiFiForThat #HiFisequencing

Powered by PacBio: Selected publications from November 2025 - PacBio November’s standout publications show how PacBio technology is impacting advances in human genomics research.

This month’s Powered by PacBio features studies showing HiFi’s impact on variant detection in paralogous loci, visualizing challenging pangenome regions, uncovering SCA10 repeat patterns, and enabling a low cost CAH screening assay.

Full recap: bit.ly/4puWugK

#PacBio #HiFisequencing #RareDisease

The 2025 Immuno SMRT Grant is open! Apply for a chance to accelerate your #immunology or #immunotherapy research with PacBio #HiFisequencing through the ProfilAIR immune repertoire profiling assay. Three winners will receive sequencing on two Vega SMRT Cells.

Apply here: bit.ly/4pKhgIG

#PacBio

The team at CHU Sainte-Justine recently reached 162.92 Gb of HiFi data! Kudos to the researchers for pushing sequencing to new heights and inspiring the global HiFi community.

Want more record-breaking runs? Stay tuned early next year for our 2026 leaderboard.

#PacBio #HiFisequencing #Genomics

One year in, Vega is now powering labs in 17 countries, helping teams adopt HiFi sequencing quickly with simple, reliable workflows.

If you're exploring long-read sequencing or considering Vega for your lab, start with our Sequencing 101 guide: bit.ly/4gGkp9t

#PacBio #Vega #HiFisequencing

Just 5 spots left! Apply for your chance to attend a 2026 genomics conference with flights, hotel, and registration covered. Meet HiFi sequencing experts and take your research further.

Apply now: bit.ly/4oJQxvy

#PacBio #TheresHiFiForThat #HiFisequencing #Conferences

Last call to join our #HiFisequencing for antibody development webinar Tuesday, November 18. Learn how full-length reads with 99.9 percent accuracy accelerate antibody discovery and improve clone selection.

Secure your spot today: bit.ly/4oDrUR6

#PacBio #AntibodyDevelopment

Attending AMP 2025? Visit booth #843 to see how PacBio HiFi sequencing is transforming clinical and translational research. Catch live Vega demos and discover the power of complete, accurate data.

Full program: bit.ly/47Ubb6y

#PacBio #AMPath2025 #HiFisequencing

See how full-length RNA isoform sequencing using #HiFisequencing helps identify novel isoforms, refine ASO design, and advance RNA-targeting drug development. Gain complete isoform resolution.

Access the brief: bit.ly/4qK9MqN

#PacBio

Discover how HiFi sequencing and Kinnex solutions deliver comprehensive genomic insights in our on-demand webinar: "Innovations in Genomics."

Watch here: https://bit.ly/42nBApp

#HiFiSequencing #Genomics #LongReadSequencing #Transcriptomics #Innovation