Research priorities in epilepsy: a consensus position paper from the European Reference Network ERN EpiCARE.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #Epilepsy #ERN #EpiCARE #EU4Health #HealthUnion #genetics #rareandcomplexepilepsies #researchfunding @stephane_auvin

Trials including participants with high SF could include either fewer participants or shorter maintenance phase.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #antiepilepticdrugs #clinicaltrials #Lrelationship #timetoevent

The DAME score predicts the risk of epilepsy in patients with autoimmune encephalitis-associated NORSE.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #autoimmuneencephalitis #etiology #NORSE #statusepilepticus

Patients receiving PER MT were more likely to achieve seizure freedom but had a higher incidence of dizziness than those receiving LEV MT.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #Chinesepatients #focalonsetseizures #Levetiracetam #Perampanel #monotherapy #seizurefreedomrate

Prolonged ASM exposure increased malformation risk, and valproate- or some lamotrigine-based dual therapies showed higher malformation risks associated with these combinations.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #AntiSeizureMedications #Pregnancy #FetalOutcomes #DrugSafety

For optimal uptake, AI should be used as a tool that complements human-centered care and clinical judgment.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #AIethics #computationalintelligence #datascience #deeplearning #IGAP #machineintelligence #machinelearning #syntheticintelligence

This case shows the potential of SqEEG to guide treatment decisions in the perioperative setting.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #epilepsysurgery #epilepsytreatment #objectiveseizuredocumentation #subcutaneousEEG #ultralongtermEEGmonitoring

New in Epilepsia – January 10, 2026
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#epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

A 1-unit serum S100B increase (in μg/L) after traumatic brain injury was associated with a 46% higher epilepsy risk.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #epidemiology #observationalstudy #posttraumatic #S100B #TBI

The symmetrical claustrum sign demonstrates high specificity in FIRES diagnosis and is considered a potential diagnostic marker.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #SCS #FIRES #claustrum #prognosis

Combining MRI and interictal iEEG abnormalities significantly improved outcome differentiation.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #epilepsysurgery #graymatter #iEEG #multimodal #superficialwhitematter

Carbamazepine was associated with increased interictal activity, while valproate–lamotrigine was associated with reduced activity in the IGEs.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #ambulatory #EEG #antiseizuremedication #IGE #interictalepileptiformdischarges #vEEG

Cluster analysis based on electronic medical records reveals dynamic phenotypic clustering reflecting the evolving nature of SCN8A-related disorders throughout the first 10 years of childhood.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #EMRs #ASM #developmentalskills #pediatric

URE patients had a median of six failed treatment strategies, including surgery or neurostimulation.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #drugresistantepilepsy #neurostimulation #resectivebrainsurgery #ultrarefractoryepilepsy

New in Epilepsia – December 13, 2025
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#epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

Prioritization of candidate genes reveals high-quality candidates that are known to influence neurodevelopment and synaptic plasticity and be druggable.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #drugtargetprioritization #genomewideassociationstudy #multispeciesanalysis #systemsbiology

The updated ILAE seizure classification proved fully applicable at secondary referral centers.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #applicability #feasibility #seizureclassification

This study establishes that early symptoms such as dysphagia, neurodevelopmental concerns, seizures, and hyperkinetic movement disorders are consistent and early clinical biomarkers of the GABRG2 p.(Ala106Thr) GoF variant.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #GABAAreceptor

Largest reported series highlighting rare but serious sEEG-related pseudoaneurysms and the need for prompt imaging and treatment.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #complication #epilepsysurgery #SEEG

In the cavernous sinus, eEEG detected IEDs with higher amplitude than scalp EEG, indicating its diagnostic potential.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #EP01 #focalonsetepilepsy #localizedepileptogenicity

Introducing a systematic sample handling protocol to assess tissue epileptogenicity at structural, functional and molecular levels.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #electronmicroscopy #electrophysiology #histology #MRI #multiscale #omics

The overall pooled prevalence of active cases of IESS was 3.33 per 100 000 population (95% CI, 1.46–5.82) in India.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #burden #infantilespasms #prevalence

Medial pulvinar entropy changes during seizures predict clinical response to deep brain stimulation in drug-resistant epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #DBS #permutationentropy #pulvinar #SEEG

Acute PHM is a clinically heterogeneous disorder with significant diagnostic and therapeutic challenges and a poor prognosis.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #cardiacarrest #LanceAdamssyndrome #myoclonicstatusepilepticus #perampanel #postanoxicmyoclonus

Dravet Syndrome is now diagnosed earlier but this has not led to earlier initiation of stiripentol treatment.⁠
doi.org/10.1002/epi4...
⁠
#epilepsy #ILAE #epilepsiaopen #efficacy #healthcareutilization #qualityoflife #statusepilepticus #stiripentol #DravetSyndrome⁠

Theory of Mind appears preserved in juvenile myoclonic epilepsy after accounting for cognitive and mood factors, highlighting broader vulnerabilities.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #cognition #executivefunction #neuropsychologicaltests #psychology

A new method called ME-MAGMA is designed to identify genes influenced by epigenetic regulators associated with epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #epigenetics #geneticgeneralizedepilepsy #GWAS #MAGMA #transcriptomics

Interrater agreement of retrospective chart reviews is highly dependent upon documentation quality.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #datareporting #drugresistantepilepsy #interraterreliability #neuromodulation #vagusnervestimulation

In 62.6% of patients with FDS, there were no red flags to indicate co-occurring epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #comorbidity #diagnosticlevelofevidence #functionalneurologicaldisorder #psychogenicnonepilepticseizures #subjective #PNES

The ELUCID Study is a prospective, multi-site, longitudinal observational study on late-onset unexplained epilepsy (LoUE).
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #cognition #dementia #elderly #lateonset