Longitudinal ctDNA analysis during chemoradiation and follow-up identifies patients at high risk of recurrence and may enable more personalized surveillance strategies in anal cancer 🔗 bit.ly/4b8JOYe
Highlights are summarised below ⬇️
#IPVSPaperoftheWeek
New modelling evidence across 67 low and lower-middle income countries shows that single-dose HPV vaccination with extended catch-up could be among the most efficient strategies for cervical cancer prevention
Highlights are summarized below ⬇️
🔗 bit.ly/4ujNyh5
#IPVSPaperoftheWeek #HPV
A large community-based study in China finds minipad-collected menstrual blood is a reliable, non-invasive option for HPV testing, accurately detecting CIN2+ and supporting cervical cancer screening programs.
🔗https://bit.ly/3Oq6Vo3
#IPVSPaperOfTheWeek #HPVtesting
A new study shows an intranasal nanogel-based therapeutic HPV vaccine induces strong mucosal & systemic T-cell immunity and prevents cervical cancer in preclinical models with supportive evidence from non-human primates.
🔗https://bit.ly/4c9UsyD
#IPVSPaperOfTheWeek #HPVvaccine #cervicalcancer
Recent #HPV vaccine trial compared #onedose to #twodoses and found one dose can effectively prevent HPV and #cervicalcancer. #ESCUDDO @NEJM
Highlights are summarised below ⬇️ and full paper link: https://bit.ly/45D3foJ
#IPVSPaperOfTheWeek #HPVvaccine
@NCI
The data linkage cohort study from Aberdeen examined #obstetric_outcomes following #HPV_vaccination. Spontaneous preterm birth showed no association with vaccination status, while reductions were observed in PPROM, PROM, pre-eclampsia and antepartum haemorrhage: bit.ly/3LMNN2E
#IPVSPaperoftheWeek
Swedish registry data show that husbands of women with anogenital cancer face increased HPV-related tonsillar and base-of-tongue squamous cell carcinoma risk, rising over time and highest in men under age 50, indicating spousal clustering. ➡️ bit.ly/4p8kcyn
#IPVSPaperOfTheWeek
Updated Cochrane review of RCTs: #HPV vaccines significantly reduce CIN2+ and genital warts in populations aged ~15–25, with no evidence of increased serious adverse events.
Full paper: https://bit.ly/4pvokt5
#IPVSPaperOfTheWeek
New evidence shows that extracellular vesicles released by Lactobacillus crispatus play a protective role in the genital tract. These nanoscale vesicles accelerate tissue repair and significantly reduce HPV16 infection in both cell and mouse models ➡️ bit.ly/4p5LyFW
#IPVSPaperoftheWeek
This global systematic review and meta-analysis shows very low HPV vaccine uptake among migrants. It also identified key barriers, and recommended strategies to improve coverage.
Highlights are summarised below 📷 and full paper link: bit.ly/3JX4c3H
#IPVSPaperoftheWeek
In #HPVrelatedcancer, viral oncoproteins drive KLF2-mediated IL-23 production in tumor macrophages, weakening CD8⁺ T-cell immunity. Blocking IL-23 restores immune function and boosts HPV16 E6/E7-targeted #immunotherapy.
➡️bit.ly/3WVRMvK
Paper highlights have been summarized ⬇️
#IPVSPaperOfTheWeek
A US study using a 20-year Markov model found that when women newly diagnosed with cervical cancer are screened for anal HPV, evaluated for epithelial dysplasia, and treated for anal HSIL, they’re less likely to develop or die from anal cancer. ➡️ bit.ly/43OwDr7
#IPVSPaperoftheWeek
#HPV vaccination is expanding globally, yet coverage remains far below elimination targets. This systematic review maps national programs and highlights persistent inequities, urging stronger delivery strategies to close the gap.
📄 Read the paper: bit.ly/4nwJ9CH
#IPVSPaperoftheWeek
Recent study among 2335 adolescent girls and young adult women found population-level effectiveness and herd protection were robust 17 years after #HPV #vaccine introduction.
📄 Read the paper: bit.ly/47b5Nul
Paper highlights ⬇️
@einsteinmededu.bsky.social @jamapediatrics.com
#IPVSPaperoftheWeek
Celebrating 164 IPVS Papers of the Week since June 2022! 🎉
Thank you to all authors and IPVS Social Media Committee members for your efforts and hard work.
Here’s to more milestones ahead!
💡Members can explore all papers on the IPVS Education Center: bit.ly/4hahmqk
#IPVSPaperOfTheWeek
A global systematic review reveals most (148/194) countries have introduced HPV vaccination, but coverage among girls aged 9–14 remains far below target. Coverage is highest in upper-middle-income countries, indicating geographic disparities.
📄 bit.ly/4mWLVBF
Paper highlights ⬇️
#IPVSPaperoftheWeek
New global analysis shows major inequities in #CervicalCancer screening and follow-up. Integrating #SelfCollection and #HPV point-of-care testing is a promising step toward equitable #Screening and #CancerControl. ➡️ bit.ly/46816Rx
Paper highlights have been summarized ⬇️
#IPVSPaperoftheWeek
A woman with an immune defect developed #betaHPV–integrated skin cancer. Stem-cell transplant restored T-cell function and cleared all HPV diseases — revealing the direct #carcinogenicity of β-HPV under immune deficiency. ➡️ bit.ly/3HwYRis
Paper highlights have been summarized ⬇️
#IPVSPaperoftheWeek
Recent study in India found the presence of HPV58 and HPV59 in #oropharyngeal #cancer cases. The HPV burden at this site may expand beyond just HPV16/18. Tobacco and alcohol still remain important risk factors for this cancer.
📄 Read the paper: bit.ly/3Jl5aGm
Paper highlights ⬇️
#IPVSPaperoftheWeek
Large, long-term Swedish cohort study shows 1–2 doses of quadrivalent #HPVvaccine before age 15 protect against high-grade cervical lesions comparable to 3 doses.
📄 Full paper: bit.ly/4oR90au
Paper highlights ⬇️
#IPVSPaperoftheWeek
#PersistentInfection of HPV requires genome maintenance and partitioning during cell division, but #LiveCellMonitoring tools were lacking. This study applies #ANCHOR technology to visualise HPV18 genome tethering, providing a tool for therapy development. ➡️bit.ly/3ITp8Yu
#IPVSPaperoftheWeek
People with HIV are at higher risk for head and neck cancer.
Recent study found that HIV was associated with 43 % higher hazard of death for oropharyngeal cancer. Read the paper➡️bit.ly/46qm9QV Paper highlights have been summarized 👇
#IPVSPaperoftheWeek #HPVResearch
New study in Annals of Internal Medicine: anal cancer screening is cost-effective for MSM living with HIV aged 35+➡️ bit.ly/40VTakk
Paper highlights have been summarized 👇
#IPVSPaperoftheWeek #HPV #HIV #CancerScreening
A study by Giesbrecht et al. on wastewater testing reveals 24 circulating HPV types in Canada, including high-risk and vaccine-preventable types like HPV-16 and -18. A promising tool for public health surveillance. @umanitoba.bsky.social
➡️ bit.ly/44CnCRC
#IPVSPaperOfTheWeek
Nuclear K6A boosts #HPV16 oncogene expression via TEAD1, offering insight into #viral-gene-regulation, cervical cancer development, and cell-type-specific oncogenic susceptibility.
Read the paper➡️bit.ly/46qhcHK
#IPVSPaperoftheWeek
Can HPV in semen affect fertility outcomes? This prospective cohort study examined HPV prevalence in infertile men and its potential impact on ART success. While no major effects were found, subtle trends suggest HPV status may still matter.
Read the paper👉bit.ly/3Tkt1aC
#IPVSPaperOfTheWeek
#BetaHPV49, linked to skin cancer, uses a splice site in E6 previously seen only in #highrisk alpha-HPV. This site regulates E6 levels and is essential for keratinocyte immortalisation, revealing similarities in #viralpathogenesis.
Read the paper 👉https://bit.ly/4dTHST5
#IPVSPaperOfTheWeek
New paper published in the JNCI: Journal of the National Cancer Institute on racial and ethnic heterogeneity in #HPV-related cancers by anatomical site 👉https://bit.ly/43hE5Kb
#IPVSPaperOfTheWeek #Epidemiology #HPVCancer
New hope for penile cancer: Trop-2 is highly expressed in HPV-positive tumors, supporting sacituzumab govitecan as a promising targeted therapy. Nectin-4 expression is limited—biopsy of metastases is key before treatment.
Read the paper 👉 bit.ly/4kebgFC
#IPVSPaperOfTheWeek #cancerresearch
HPV test results aren’t just "new infection vs clearance": many are reactivations or low-level persistence. A new #IPVS review urges framing as “HPV detected” vs “not detected” to better guide counseling, screening & vaccination.
Read more 👉https://bit.ly/4cUR09k
#IPVSPaperOfTheWeek
