Just wrapped up two inspiring weeks in Florida for #MathOnco25 and the IMO Workshop at @moffittnews.bsky.social - made possible by a generous travel award from the organizers.
Incredible science, great people, and a community that keeps pushing boundaries.

#MathOnco25 Conference done…on to the IMO Workshop @mathonco.bsky.social which begins this evening! The workshop is in its 13th year, whoa! Looking forward to the next 5 days of team science! 🥳

Thank you, @sandyanderson.bsky.social @gliomath.bsky.social for organizing a truly stimulating #MathOnco25 conference at the iconic #thedoncesar. These talks will pave the way to focused efforts towards eradicating #cancer. @moffittnews.bsky.social #mathematical #Oncology #CancerResearch

While I might not agree with the definition necessarily this was a thoroughly enjoyable and thought provoking presentation, great way to cap this #MathOnco25

Last speaker at #MathOnco25 is our own @mathonco.bsky.social Jeffrey West that provides a study of the #mathonco literature to produce this definition of MathOnco: the use of interpretable models to understand and improve cancer therapy

Great last didactic at #MathOnco25 by @andriy-marusyk.bsky.social describing the complex landscape of evolutionary and ecological mechanisms aiding cancers become treatment-resistant. Andriy and I both share the idea of maps as an example of what models can be

Sarah Brüningk explains that "agent-based model" has very different meanings in mathematical biology and AI. Perhaps we can combine the two model types? #MathOnco25

4th (and last) day of #MathOnco25. Excellent work @sandyanderson.bsky.social and @gliomath.bsky.social. Looking forward the next one, hopefully in 2026

Last keynote at #MathOnco25 by Sarah Bruningk talking about #AI in #Medicine. While generally optimistic about AI in medicine she is aware of the challenge that AI works best when there is a lot of data and that is almost never the case in clinical oncology

In her #MathOnco25 plenary, Sarah Brüningk motivates mechanistic learning in mathematical oncology, drawing on her recent review paper: www.frontiersin.org/journals/imm...

Bob Gatenby finishes his phenomenal #MathOnco25 talk with this stunning figure and conclusion: "Cycles within cycles may allow metastatic prostate cancer to be converted to a chronic disease". The results are from a new paper: onlinelibrary.wiley.com/doi/10.1002/...

Joel Brown at #MathOnco25 draws parallels between the evolution and ecology of cancer and of dogs, elephant shrews and (of course) squirrels. Cancer redefined as "a disease of uncontrolled proliferation by transformed cells subject to evolution by natural selection". aacrjournals.org/mcr/article/...

Now @kitcgallagher.bsky.social at #MathOnco25 presents his recent research on predicting treatment outcomes to identify which patients will benefit the most from adaptive therapy. Preprints and papers at scholar.google.com/citations?us...

Franco Pradelli presents one of the most beautiful slides so far at #MathOnco25, on the topic of exploiting the cost of addiction in anaplastic large cell lymphoma

Fantastic to have adaptive therapy pioneer Jingsong Zhang here at #MathOnco25 talking about a third-generation adaptive therapy trial for metastatic prostate cancer underway at the Moffitt Cancer Center, informed by Jill Gallagher's mathematical modelling. Preprint: www.medrxiv.org/content/10.1...

Thursday keynote at #MathOnco25 with @robjohnnoble.bsky.social showing a wealth of #MathOnco models of cancer evolution and evolutionary-enlightened therapies. Notice the bingo card: he showed enough different math models to fill up the card!

Optimal dosing of anti-cancer treatment under drug-induced plasticity - npj Systems Biology and Applications npj Systems Biology and Applications - Optimal dosing of anti-cancer treatment under drug-induced plasticity

Really nice #MathOnco25 talk by Einar Bjarki Gunnarsson on optimal dosing of anti-cancer treatment under drug-induced plasticity, showing "that the optimal dosing strategy steers the tumor to a fixed equilibrium composition between sensitive and tolerant cells" www.nature.com/articles/s41...

Biologically informed deep neural networks provide quantitative assessment of intratumoral heterogeneity in post treatment glioblastoma - npj Digital Medicine npj Digital Medicine - Biologically informed deep neural networks provide quantitative assessment of intratumoral heterogeneity in post treatment glioblastoma

Now at #MathOnco25, co-organiser @gliomath.bsky.social presents recent work showing that the predictions of an AI method massively improved when coupled with a mechnaistic mathematical model www.nature.com/articles/s41...

From Tampa to the gorgeous St. Pete for #MathOnco25. Science and views for the next few days! 😍

Great talk by collaborator Joon Hyun Song from @ceel-damaghilab.bsky.social working on a simple model of the storage effect to explain the role of temporal fluctuations in intra tumor heterogeneity #MathOnco25

At #MathOnco25, @rrockne.bsky.social explains why he so loves SINDy (sparse identification of nonlinear dynamics).

Great didactic at #MathOnco25 by @rrockne.bsky.social who starts his presentation with a very Freudian slip by thanking organizers @gliomath.bsky.social and #SINDy (meaning @sandyanderson.bsky.social)

Phenomenal talk. I've never seen a more elegant integration of mathematical modelling and molecular biology. #MathOnco25

Great talk, lots of cool dynamics in Galit's talk and great call to arms from her at #MathOnco25. While @harvard.edu's federal grants have been suspended the research is still great and worth doing

Galit Lahav - Wikipedia

First plenary talk at #MathOnco25 today is Harvard's Galit Lahav about the temporal dynamics of p53 and how it lends itself to #MathModeling

Day 2 of #MathOnco25 in St Pete Beach, FL

#MathOnco25 that is

Great didactic at #MathOnco25 by @dwodarz.bsky.social showing the importance of space...and turnover in #cancerevolution

Our own Tatiana Miti highlighting the importance of data to find out the initial configuration of an ABM describing early stages in metastasis, something which is hard to study with experimental models and clinical data #MathOnco25

Population structure reverses selection of variants with proportionally scaled birth and death rates A frequently observed phenomenon across the kingdom of life is that a higher reproduction rate can be accompanied by higher mortality. During tumor progression, variants emerge that both reproduce and...

Finally, @dwodarz.bsky.social at #MathOnco25 presents soon-to-be-published results showing that, in spatially structured populations, increased turnover can render mutants effectively less fit, even if they have higher life-time reproductive output www.biorxiv.org/content/10.1...