🔥Hot Off the Press | ❓Could a common #vitamin hold the key to treating rare genetic disease? 🧬👇
📃A
@CellCellPress
research puts #VitaminB3 (niacin) in the spotlight:
🔸Dramatically improves survival and symptoms in a #NAXD deficiency #MouseModel

The figure shows the fibrosis analysis. Top panel shows images of diaphragm, quadriceps and tibialis anterior sections from mice stained with Picro Sirius Red, which reveal collagen deposition as an indicator of fibrosis. Bottom panel shows violin plots representing the quantification of the percentage area of fibrosis in the diaphragm, quadriceps or tibialis anterior of wild-type, heterozygous and homozygous mice aged 2, 6 or 12 months.

Arístides López-Márquez, Cecilia Jiménez-Mallebrera & co used CRISPR/Cas9 to generate the first #MouseModel of a pathogenic variant that involves glycine substitutions in the triple helical domain of collagen VI alpha chains and leads to congenital #MuscleDisease.
Read doi.org/10.1242/dmm....

#Prostaglandin agonists produce an unexpected #analgesiceffect and prevent chronic postsurgical pain (#CPSP) in this #mousemodel

www.bjanaesthesia.org/article/S0007-0912(25)00...

Multipanel figure showing comparative histological images of Plp1-driven MPNST-like tumor and corresponding Tyr-driven melanoma.

Julien Debbache, Lukas Sommer & co generated a novel sporadic #MouseModel of Nf1 wild-type malignant peripheral nerve sheath tumours, driven by conditional expression of oncogenic BrafV600E and loss of Pten in the glial lineage.

#sarcoma

Read doi.org/10.1242/dmm....

Multipanel figure showing pathological changes in the brains and the peripheral organs of the investigated mouse models. Panel A: Images of the brains obtained from C57BL/6J mice not infected with JEV (Control), C57BL/6J, NCG and NCG-hSTAT2+/+ mice showing retention of Evans Blue. Panel B: Images, showing histopathological changes of the hippocampal area in the brains of mice as described in panel A. Panel C: a graph shoeing quantification of neuronal cell density in the hippocampus of the mice as described in panel B. Panel D: Images showing immunofluorescence staining of neuronal cells in the dentate gyrus region. Panel E: Histological images of liver and spleen tissues in mice, showing pathological changes in these peripheral organs.

Caiqin Zhang, Yangchao Don, Changhong Shi, & co developed a humanised STAT2 #MouseModel of Japanese #encephalitis #virus, which exhibited a phenotype resembling clinical human infections, characterised by elevated viral load and increased proinflammatory cytokines.

Read doi.org/10.1242/dmm....

Abigail Poff, Nicole Moss & @debbysilver.bsky.social generated a #MouseModel of the #DDX3XSyndrome and demonstrated that missense and loss-of-function variants have similar effects on #corticogenesis but act through distinct molecular targets.

#RareDisease

Read doi.org/10.1242/dmm....

Chemoprevention of hepatocellular carcinoma using N-acetylgalactosamine-conjugated siRNAs Editor's choice: Comparison between five N-acetylgalactosamine-conjugated siRNAs in several mouse models of liver cancer found ANLN to be a promising target for hepatocellular carcinoma…

In August's #EditorsChoice, Gianna Maggiore, @haozhulab.bsky.social & co showed strong clinical potential in reducing #HepatocellularCarcinoma by targeting the actin-binding protein anillin via #siRNA knockdown in #MouseModel.

⚡ doi.org/10.1242/dmm....
📰 doi.org/10.1242/dmm....

Making and Genetically Manipulating Mouse Embryos 2026 This hands-on workshop teaches participants to make and manipulate mouse embryos to new genetic models and efficiently manage mouse strains.

🐭 Expand your research skills in mouse model development

Join @jacksonlab.bsky.social's hands-on workshop combining expert instruction with practical training for innovative #MouseModel development.

📅 March 9 – 13, 2026
👥 Limited to only 16 participants

Save your spot: www.jax.org/education-an...

Selection and transmission of the gut microbiome alone can shift mammalian behavior - Nature Communications Here, the authors present evidence that the gut microbiome alone, without changes in the host genome, can shape how animals respond to selection, identifying a bacterium and its metabolite that indepe...

🚨✨ New paper: “Selection and transmission of the gut microbiome alone can shift mammalian behaviour”.

DOI: doi.org/10.1038/s414...

Read below 👇

#Microbiome #Evolution #MouseModel #Behavior #Neurobiology #EvoDevo #Neuroscience

Immunohistochemical detection of GM2 ganglioside in dKO, KIKO and CON brains. Sections were selected from similar areas of the brain for matched pairs. Sections for each matched pair were stained together and photographed at 63× using a Zeiss Axioimager equipped with ZEN software. Many images are taken from within the same field of view as the 20× images shown in Fig. S6A. Specifically, data in Fig. 6, panels E,F,G,I,J,N, and O are also shown in Fig. S6A, panels A,B,C,I,J,N, and O respectively. The presence of a red-brown staining signal for GM2 ganglioside was present in CON brains but much more broadly and abundantly present in the sections from the dKO and KIKO brains. Arrows indicate cells that have low levels of GM2 in CON (A,C,E,F,I,K,M,O), compared to the higher levels of GM2 present in vacuolated cells (B,D,F,H,J,L,N,P). Arrows in panels A-D identify Purkinje cells. Scale bars: 20 µM. These images are representative of those from three different pairs of animals.

Emily Barker & co generate and characterise mouse models of complete and partial HexA deficiency that are suitable for testing a broad range of therapies for Tay-Sachs disease. 🐭 doi.org/10.1242/bio....

#TaySachsDisease #MouseModel

✨Final spotlight of this series: Our open access protocol on a self-medication #MouseModel of #ChronicPain that helps assess spontaneous #PainRelief & #DrugAbuse liability

🔗 doi.org/10.21769/Bio...
Cabañero et al. (2022), co-authored by Beltrán Álvarez & Rafael Maldonado

#Neuroscience #Analgesics

Frontiers | A male mouse model of WIN 55,212–2 self-administration to study cannabinoid addiction We have established for the first time a mouse model of cannabinoid addiction using WIN 55,212-2 intravenous self-administration (0.0125 mg/kg/infusion) in C...

1️⃣ Del Mar Cajiao-Manrique, Maldonado & Martín-García (2023) doi.org/10.3389/fpha...
📖 A self-administration mouse model to study #CannabinoidAddiction

💡This novel #MouseModel provides a rigorous tool to study #CannabinoidAddiction & the neurobiological mechanisms of #vulnerability vs. #resilience.

Novel MEPAN #MouseModel recapitulating #HumanPhenotype of #MovementDisorder, #OpticNeuropathy, defects in protein #Lipoylation, & reduced mitochondrial #OxidativePhosphorylation in the #Brain doi.org/10.1073/pnas... #MitochondrialMedicine #TranslationalScience

In a First, Scientists Record Decision-Making as It Happens Across a Whole Mouse Brain An extensive brain map shows how regions collaborate during complex decision-making. We’re constantly making decisions. If I get the pumpkin spice latte, would it make me happier than my usual black...

In a First, Scientists Record Decision-Making as It Happens Across a Whole Mouse Brain #Science #Biology #Neurobiology #Neuroscience #MouseModel #BrainResearch

Scientists Rub Solution On Mice To Watch Brains Grow #Science #Biology #Neurobiology #BrainDevelopment #Neuroscience #MouseModel

White graphic with orange along the bottom reads, ""The content of the course was great and very informative. I appreciated how knowledgeable the instructors were and how willing they were to work with us individually." — Senior Research Technician | Asklepios BioPharmaceutical, Inc. | The Jackson Laboratory."

🐁 Mastering #SurgicalTechniques in the #MouseModel isn't just a skill — it's essential for high-quality, reproducible #BiomedicalResearch.

Learn in-demand procedures with @jacksonlab.bsky.social this fall:
📅 Nov. 3 – 6 | Bar Harbor, ME
📅 Dec. 2 – 5 | Farmington, CT

www.jax.org/education-an...

🐭 Just published online in JPS❣️
"Podoplanin hetero-insufficiency mice with inflammation in the jejunum demonstrates a good animal model of congenital protein-losing enteropathy"
-- Toshio Ohhashi et al.
🔗 [https://doi.org/10.1016/j.jphyss.2025.100031]
#MouseModel #JPhysiolSci

Examining mechanisms relevant for restoring #Erythropoiesis & mitigation of pro-inflammatory IFNγ action in #MouseModel #Anemia of #Inflammation (AI) doi.org/10.1182/bloo... #TranslationalScience

Now LIVE - 4th episode of the #NEATCast tackles how brain stimulation works at the #neuron level to treat #depression.
Learn about a #MouseModel of #chronicstress that replicates #depression in humans and how Scott Wilke's brilliant team mimics human #TMS in animals ...
🧵🧵

'Completely new and totally unexpected finding': Iron deficiency in pregnancy can cause 'male' mice to develop female organs Low iron levels can flip the genetic switch on a mouse's sex during development, causing XY embryos to grow female features. But it's not clear whether the effect applies to humans.

'Completely new and totally unexpected finding': Iron deficiency in pregnancy can cause 'male' mice to develop female organs #Science #Biology #DevelopmentalBiology #IronDeficiency #PregnancyResearch #MouseModel

Congrats to the Westlake University team! 🎉
FRCaMPi & SomaFRCaMPi outperform jRGECO1a and enable high-res in vivo imaging in zebrafish and mice.
Watch the highlights 👉 www.ebraincase.com/support/lite...

#CalciumImaging #Neuroscience #TwoPhotonImaging #Zebrafish #MouseModel #FRCaMPi #SomaFRCaMPi

Digital Twin of Mouse Brain Predicts Neuron Activity and Connections With Striking Accuracy Stanford-led researchers have developed a highly accurate AI-powered digital twin of the mouse visual cortex, trained on neural data from mice watching movies. This model can generalize responses to n...

Digital Twin of Mouse Brain Predicts Neuron Activity and Connections With Striking Accuracy 🎥🧠🐭 www.azoai.com/news/2025041... #Neuroscience #AI #DigitalTwin #BrainResearch #MouseModel #VisualCortex #NeuralNetwork #FoundationModel #BrainSimulation #NeuroAI

Using #CRISPR 🧬we generated a new knock in #mousemodel 🐁 to block SUMOylation at endogenous K408 allowing us to study what happens to TDP-43 when it can no longer be SUMOylated at this site.

Angiogenesis-associated neurons in the compressed cord. Representative micrograph of axial sections derived from WT mice and Enpp1flox/flox/EIIa-Cre. (A, B) Double immunohistochemistry with anti-Vegf (green) and anti-Neun (red) antibodies revealed Vegf-positive neurons in the Enpp1flox/flox/EIIa-Cre mice spinal cord sections in contrast with normal spinal cord sections on white matter and gray matter. (E, F) Double immunohistochemistry with anti-Vwf (green) and anti-Neun (red) antibodies revealed Vwf-positive neurons in the Enpp1flox/flox/EIIa-Cre mice spinal cord sections in contrast with normal spinal cord sections on white matter and gray matter. (C, D, G, H) Chronic progressive compression of the cervical spinal cord significantly decreased neuroangiogenesis, as measured by unbiased cells/fields of view. (I) Relative Vegfa, Vwf, Mmp9, Mmp2, and Pecam1 expression, as assessed by RT-qPCR. (J) Analysis of Vegf protein expression levels. Data are expressed as mean ± SD. *p < 0.05, **p 

Recent work by Zhongyuan He & coauthors unveils a validated mouse model of chronic spinal cord compression, mimicking ossification of the posterior longitudinal ligament in humans: onlinelibrary.wiley.... #SpinalCordResearch #OPLL #MouseModel

Could a single amino acid change in our genome have nudged us toward language?
New study humanizes the NOVA1 gene in mice—and subtly rewires their vocal behavior.
Is this how speech began?

#Genetics #Neuroscience #Evolution #Language #RNA #SciComm #FOXP2 #MouseModel

🧬 A new study uncovers molecular mechanisms behind #endometriosislesion development using a #mousemodel!

By analysing #geneexpression in endo tissue and endo-like lesions at different stages in mice, Aussie researchers found key changes that mirror human

Lithium Restores Brain Function and Behavior in Autism - Neuroscience News Lithium, a drug widely used for bipolar disorder, may also treat autism spectrum disorder (ASD), according to new research.

#Autism #MouseModel #BrainFunction
#Lithium

neurosciencenews.com/lithium-auti...

#SharedFacts #HealthScience

During my PhD I worked with transgenic mice overexpress human tau, specifically the 4R/2N isoform, bearing the P301L mutation under the control of the neuron-specific murine Thy1 promoter. Who works with this mouse model? Raise your hands! #neuroscience #mousemodel #TauP301L #ftdp-17

"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."

doi.org/10.1177/0960...

#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology