Sirtuin 1 is an endogenous NETosis inhibitor that becomes dysfunctional in diabetes Neutrophil sirtuin 1 naturally inhibits neutrophil extracellular trap formation (NETosis) under healthy conditions; its reduced activity in diabetes leads

Starting off our March 2026 issue of #JLB - "Sirtuin 1 is an endogenous #NETosis inhibitor that becomes dysfunctional in #Diabetes" by Liang De Wang & colleagues

Nuclear mechanobiology rules immune cells’ functions: from differentiation to cell trafficking and pathogen killing The immune system functions within tissue microenvironments of mechanical and geometrical constraints. Within these constraints, immune cells must rapidly move and execute effector functions to reg...

Excited to share our latest #review on how the mechanobiology of the nucleus impacts immune cell function, including #NETosis, #migration, and #differentiation.

doi.org/10.1080/1949...

This was a fantastic collaborative effort with @hawa-racine.bsky.social, along with Sarah & Janina from our lab!

Enhancement of NETosis by ACE2-cross-reactive anti-SARS-CoV-2 RBD antibodies in patients with COVID-19 - Journal of Biomedical Science Background High levels of neutrophil extracellular trap (NET) formation or NETosis and autoantibodies are related to poor prognosis and disease severity of COVID-19 patients. Human angiotensin-convert...

This may reduce the production of cross-reactive antibodies (CR Abs) that contribute to pathological inflammation & #NETosis

link.springer.com/article/10.1...
Immunosuppression, such as in HIV infection,

Multi-omics evidence shows alcohol aggravates #EpilepticSeizures via the MPO-driven #NETosis pathway, highlighting a promising therapeutic target in alcohol-related #Epilepsy. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

We look forward to hearing feedback from the community on our #preprint where we used #NETosis as a platform to show that chromatin decompaction inside the nucleus directly regulates cell mechanics. This work identifies long-range biophysical impacts of chromatin in mammalian cells.

Frontiers | Neutrophil extracellular traps in central nervous system pathologies: A mini review Neutrophils are rarely found in the brain because of the blood-brain barrier (BBB), but several diseases disrupt the BBB and cause neuroinflammation. In thes...

#Cytokines released by activated immune cells can induce #NETosis, while NETs themselves further fuel the inflammatory response and autoantibody production, which can perpetuate NET formation

www.frontiersin.org/journals/med...

(e.g., myeloperoxidase-DNA complexes) have been found in both acute & LC patients, indicating an incomplete resolution of #NETosis after the initial infection , prolonged NET formation contributes to the chronic inflammation, immunothrombosis (micro-clots) & vascular damage .

Impact of antiplatelets, anticoagulants and cyclic nucleotide stimulators on neutrophil extracellular traps (NETs) and inflammatory markers during COVID-19 - Journal of Thrombosis and Thrombolysis While the association between coronavirus disease-19 (COVID-19) and neutrophils extracellular traps (NETs) is recognized, uncertainties remain regarding its precise onset, timing of resolution and target therapy. To assess changes in inflammatory and NET markers during the first week of COVID-19 hospitalization, and the association with disease severity. “In vitro” experiments investigated the effect of antiplatelets, anticoagulants, and cyclic nucleotide stimulators on NETs release. Prospective cohort study, changes in interleukin (IL)‐6, IL-8, IL-17, TNF-α, RANTES, PF4, and citrullinated-H3 (citH3) levels within each outcome group was evaluated using ANOVA. Differences between moderately ill, critically ill, and non-survivors were determined using Kruskal–Wallis and logistic regression. Healthy neutrophils were stimulated with phorbol-12-myristate-13-acetate (PMA) or COVID-19 sera and treated with unfractionated heparin (UFH), low molecular weight heparin (LMWH), aspirin (ASA), ticagrelor, cinaciguat, sildenafil, and milrinone. The proportion of NETosis was assessed using IncuCyte Cell Imager. Of the 125 patients, 40.8% had moderate COVID-19, 40.8% had critical COVID-19 but recovered, and 18.4% died. From admission to hospitalization day 8, IL-6 levels decreased in moderately and critically ill, but not in non-survivors, while citH3 levels increased in critically ill and non-survivors. IL-6, IL-8, and TNF-α levels were associated with critical and fatal COVID-19. The release of NETs by neutrophils stimulated with PMA or COVID-19 sera was decreased in the presence of ASA, UFH, LMWH and cyclic nucleotide stimulators in a dose-dependent manner. In the first week of hospitalization, NET markers rose later than inflammatory markers in severe COVID-19 cases. Cyclic nucleotide stimulators, ASA and heparin may emerge as treatment approaches as they may modulate NETosis. Graphical Abstract

Studies on AD pathology show a significant overlap with the inflammatory mechanisms seen in #longCOVID, including the roles of #neutrophils & #NETosis.

www.frontiersin.org/journals/neu...

link.springer.com/article/10.1...

www.frontiersin.org/journals/imm...

pubmed.ncbi.nlm.nih.gov/40474772/

Scheme of how NETosis works. Neutrophils contain many granules that are filled with bactericidal enzymes. Once the cells are stimulated by the presence of pathogens, these granules release their content to the extracellular space, but also into the nucleus. Inside the nucleus, MPO and other factors lead to decondensation of chromatin, i.e. eviction of nucleosomes. The nucleus disintegrates and subsequently, the neutrophil bursts open and releases the decondensed chromatin to the extracellular space. There the NET can entrap the pathogen. As NETs are functionalized with bactericidal enzymes, they can directly kill pathogens they contact.

During #NETosis, neutrophils decondense their #chromatin by disassembling #nucleosomes. Then, their nucleus breaks down and the cells burst open. The decondensed chomatin then forms the NET.

As #NETs are sticky and functionalised with bactericidal enzymes, they can trap and kill bacteria.

Live fast, die young: neutrophils streamline their metabolism to maximize inflammation | Infection and Immunity Cell metabolism plays a key role in shaping immune cell differentiation and function, with each immune cell subset depending on distinct metabolic pathways. While there have been extensive studies and...

Just out in Infection and Immunity!
Our latest review explores how neutrophils balance antimicrobial defense with tissue protection during infection, with a focus on metabolic signaling and NETs.
Read it here: journals.asm.org/doi/full/10....
#neutrophils #immunometabolism #NETosis #hostpathogen

Mitochondria sense bacterial lactate & drive release of neutrophil extracellular traps.

Neutrophil #mitochondria sense metabolic perturbations in the phagosome.
Accumulation of bacterial #lactate is a metabolic danger signal triggering #NETosis.

www.cell.com/cell-host-mi... #ImmunoSky #MicroSky

VolitionRx Launches Innovative Model for Real-Time NETosis Study in Sepsis Treatment VolitionRx has unveiled its groundbreaking High Throughput NETs model, marking a significant advancement in the understanding and treatment of NETosis and sepsis-related diseases.

VolitionRx Launches Innovative Model for Real-Time NETosis Study in Sepsis Treatment #United_States #Henderson #VolitionRx #sepsis #NETosis

COVID Metformine netosis

As a Health Journalist @greennoise.bsky.social, have you investigated the most accessible drugs that can PREVENT the CAUSE of microthrombosis in COVID (namely, the formation of neutrophil extracellular traps)?
Did you ask MDs why they did not take any action against the risk of #netosis in #covid19?