#SpatialTranscriptomics #Visium #VeinGraft #Neointima

Late-stage Neointimal cells in grafted vessels are More Contractile & Synthetic than regenerated Medial cells

FHL1 CRISPR KO Rat▶️hyper-inflammatory, dysmorphic intima

Clin Transl Med 2024
onlinelibrary.wiley.com/doi/full/10....

PDGF/Arterial injury->
Glycolysis (PFKFB3, synergizing with HIF1α)->
de novo Lipogenesis (FASN/ACLY/ACACA/B)->
#SmoothMuscleCell proliferation, lipid loading, loss of contractile phenotype in #Neointima

SMC FASN KO🐭->⏬Neointima
J Pathol 2023
pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/...

#LongNonCodingRNA #SmoothMuscleCell

LncDACH1⏬SMC proliferation+migration & #Neointima of #ArterioVenousFistula, partially via ⏬HSP90 abundance & sequestrating SRPK1 in the nuclei

A similar pro-intimal role in #Atherosclerosis?

#NatureComms 2024
www.nature.com/articles/s41...