Bleeding prevention with desmopressin for allograft kidney biopsies: a double-blind randomized study AbstractBackground. Percutaneous kidney allograft biopsy is essential for evaluating graft dysfunction, but post-procedural bleeding remains the most frequ

Yet another ddAVP trial for kidney biopsies with neutral results

academic.oup.com/ckj/advance-...

In Clinical Kidney Journal

Previous #NephJC discussion: www.nephjc.com/news/ddavp

Bleeding Risk in Patients Receiving Omega‐3 Polyunsaturated Fatty Acids: A Systematic Review and Meta‐Analysis of Randomized Clinical Trials There is a potential concern about increased bleeding risk in patients receiving omega‐3 polyunsaturated fatty acids (PUFAs). The aims of this study‐level meta‐analysis were to determine the risk of bleeding and to assess whether this relationship ...

Omega-3 may increase bleeding risk
Probably safe when no procedure is planned, but less reassuring in high⚠️ biopsy patients, issue still under study.
If injecting therapies directly into the renal cortex, I would likely avoid omega-3 to reduce any issue #nephjc

pmc.ncbi.nlm.nih.gov/articles/PMC...

What risks of 🐠 #NephJC do u mean here @dramiliflores.bsky.social ?

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Really 2 biopsies!
Harvest and re-inject. #NephJC

Awesome, thanks for all the hard work #nephjc

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Only If I Don’t have a biopsy. Otherwise, the risk of 🐠definitely will exceed benefits 🫢 #nephjc

Welcome to #NephMadness 2026 Our beautiful baby has grown into a moody, hormonal teen.  That’s right, it’s year 14 of NephMadness!  Whether this is your first time or you are a seasoned veteran, we have all the inf…

Up next, we are taking a break on 03/24/26.
Don’t forget to play NephMadness!
www. ajkdblog.org/2026/03/01/welcome-to-nephmadness-2026/
We will return in April with WCN late breaking news. #NephJC
Good night!

Thank you #NephJC 2025-26 interns.
You’re da best

I sincerely thank all my #NephJC 2025-2026 interns!
This is our last discussion. They are #FOAMed heroes.
We could not do what we do without them. ♥️

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#NephJC

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As much as I love kidney biopsies, still believe we can maximize nephroprotective 💊. So many Q for the phase 3 RCT #nephjc

plus, voting rights come with signing up for it too, 🤓😃🙏💛
#nephjc

Please thank your #NephJC 2025-2026 interns!
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minimally invasive? Havd you seen the needles? #NephJC

Don’t forget to take a fish oil supplement, 🐠🤓😃
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💯 this

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Not sure - even if it works - usage will depend upon
- cost
- if full GDMT (4 pillars) brings down slope of GFR < 1 ml/min/year > then not sure of the added benefit

But this may be a couple of injections and done option vs daily pills?

#NephJC

Everything said and done, once it reaches clinical practice - implementation is going to be pretty hard, coz the already established treatments are much simpler. And getting a patient to agree to an invasive procedure like a renal biopsy is gonna be next to impossible !
#NephJC

A heartfelt thank you to Brian,Christina and Swapnil for helping me with this beautiful script and to all of our mentors for the ongoing guidance and support! Brian Rifkin, @christina@nephroseeker.medsky.social, #NephJC

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Yeah

And for the low numbers in a phase 2 RCT we won’t expect a lot of these events anyways - so that’s OK

#NephJC

A sincere thank you to my #NephJC interim team members.
Akshaya Jayachandran Bogdan Agavriloaei @nataliaroxona.bsky.social

Happy to enrol patients - a phase 3 RCT is clearly a reasonable option

#NephJC

T3q
Great discussion! #NephJC
Do you think we are entering the era of remission, and dare I say it, cures for chronic kidney disease.
Slowing progression is great, but regenerative treatments are the future! #NephJC