Younger age (≤40), late‑line therapy, and prior platinum were linked to shorter PFS.
Toxicities were manageable, with hematologic AEs most common.
This study adds valuable Asian real‑world evidence to guide PARPi use.
#BreastCancer #PARPi #RWE #PrecisionOncology
#Review
PARPs and #PARP inhibitors: molecular mechanisms and #clinical #applications
doi.org/10.1186/s435...
#PARPi #inhibitor #Cancer #Virus
This review explores the action mechanism of PARPi, the mechanisms underlying #PARPi resistance in cancers, and summarizes the strategies to overcome PARPi resistance, to extend PARPi applications and improve patient outcomes. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107
🔦 buff.ly/hlA2obL
#PARPi #BladderCancer #BRCA #
🔍 PARP inhibitors in advanced prostate cancer @tamedoncol.bsky.social
✅ Effective in HRR-deficient mCRPC
🔗 Promising combos with ARSi, radiation, chemo & more
📘 Future directions explored
Read the review 👉 buff.ly/FPovbjB
#ProstateCancer #PARPi #Oncology
BRCA1/2-mutant early #BreastCancer: review urges region-tailored testing in Latin America, MRI-first screening, and shared surgical decision making. Neo-adjuvant platinum can raise pCR, while adjuvant olaparib improves OS. #BRCA #TNBC #PARPi #Latam
6/6 Our findings suggest that lncRNAs could be promising biomarkers to guide PARPi therapy and support better treatment decisions in ovarian cancer.
There’s still much to test before this can move into the clinic, but the potential is exciting.
#OvarianCancer #HGSC #LncRNA #PARPi #Biomarker
5/6 Functionally, this lncRNA helps maintain genome stability by regulating DNA replication.
Loss of it speeds up replication, causing DNA damage + instability.
#OvarianCancer #HGSC #LncRNA #PARPi #Biomarker
4/6 Even better: it’s detectable in both tissue and plasma.
That means it could work as a minimally invasive blood-based biomarker for HRD, measurable with a simple RT-PCR test.
#OvarianCancer #HGSC #LncRNA #PARPi #Biomarker
3/6 The top hit: ENSG00000272172.1
Upregulated in HRD+ tumors Strongly correlated with HRD-score in TCGA + independent samples
Higher expression → better overall survival
#OvarianCancer #HGSC #LncRNA #PARPi #Biomarker
2/6 We asked: could long non-coding RNAs (lncRNAs) be predictive? We found in the TCGA data a panel of 29 lncRNAs linked to HRD status and drug sensitivity in HGSC tumors. #OvarianCancer #HGSC #LncRNA #PARPi #Biomarker
1/6 High-grade serous ovarian cancer (HGSC) is one of the deadliest cancers. PARP inhibitors (PARPi) help patients with homologous recombination deficiency (HRD), especially those with BRCA1/2 mutations, but current biomarkers are limited. #OvarianCancer #HGSC #LncRNA #PARPi #Biomarker
Tao Xie from my group giving her last milestone seminar today for her PhD - "Strategies to improve the response to PARP inhibitors in pre-clinical models of ovarian cancer". A joy to watch her nail this today. Great culmination of her hard work during her PhD! #ovariancancer #PARPi #PhDLife 🧪
Olaparib synergy screen reveals Exemestane induces replication stress in triple-negative breast cancer
➡️ buff.ly/vPDXjxq
#TNBC #PARPi
This #MostRead review summarizes the mechanism of action of #PARPi drugs, the current status of different PARPi drugs, and the mechanisms underlying PARPi resistance, while also outlining strategies to overcome #PARPiResistance. #medsky
#CallForReading #OpenAccess:
buff.ly/LiHERth
An engaging review! Most downloaded article!
This review discusses the underlying mechanisms of #PARPi resistance, summarizing promising solutions to overcome PARPi resistance, with the goal of extending PARPi applications and improving patient outcomes. #medsky
www.sciencedirect.co...
🖥️ 🧬 Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data
🔗 buff.ly/2kAh3KA
🖊️ @CaldasLab
#CancerGenomics #BRCA1 #PARPi #MachineLearning
#HealthPolicy #PublicHealth #hpi #hphci #dpm #harvardmedicalschool #bidmc #obgyn #parpi #valueinhealth #research @deptpopmed.bsky.social
SciTech Chronicles. . . . . . . . .Mar 8th, 2025
bit.ly/stc030825
#BRCA1 #BRCA2 #PARPi #cytotoxicity #Basra #Mesopotamia #irrigation #Euphrates #diabetes #gut #beta-cells #C.dubliniensis #ionosphere #thermosphere # Meridian-Project #TIEGCM #kelps #micronutrients #biosorption #phytomining
Mechanism of PARP inhibitor resistance and potential overcoming strategies
This review discusses the underlying mechanisms of #PARPi resistance, summarizing promising solutions to overcome PARPi resistance, with the goal of extending PARPi applications and improving patient outcomes. #medsky
#OpenAccess: www.sciencedirect.co...
NCCN Funds Prostate Cancer Research to Enhance Patient Care and Management Strategies #USA #Plymouth_Meeting #NCCN #Prostate_Cancer #PARPi
3) Prof. Jennifer Guerriero the #macrophage expert @danafarber.bsky.social #Harvard talks on #TAM /Impact of #PARPi #Inhibitor on #Macs -IT INDUCES SUPPRESSIVE MACS! @breastcancernow.bsky.social @bccroc.bsky.social @ibcnetworkuk.bsky.social @sitcancer.bsky.social
#Bridge2024 #FinishCancer
2) Prof. Jennifer Guerriero the #macrophage expert @danafarber.bsky.social #Harvard talks on #TAM complexity. Impact of #PARPi #Inhibitor on #Macs #TNBC / @breastcancernow.bsky.social @bccroc.bsky.social @ibcnetworkuk.bsky.social @sitcancer.bsky.social
#Bridge2024 #FinishCancer
#ESMO resources from HRR - HRD testing in #ovarian #cancer
Along with evidence for #PARPi utility in ovarian cancer #gyn #gcsm
✅Telomeric allelic imbalance,
✅loss of heterozygosity,
✅large scale transitions
- form a genomic scar score/instability score
>42 significant Myriad score.
CBM researchers find a #BRCA2 variant that increases ssDNA binding causing hyper-recombination in cells. These cells show high sensitivity to #PARPi and MMC underscoring potential clinical implications in #breastcancer patients
Read the full article:
academic.oup.com/nar/advance-ar…
