PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition - Nature Cardiovascular Research Tan et al. identify PRDM16 as a key repressor of fibrotic switching in smooth muscle cells and show that its downregulation in atherosclerosis drives smooth muscle cells toward a synthetic fate, promo...

#PRDM16 identified as gatekeeper for #proatherogenic phenotype switching of #VascularSmoothMuscleCells (SMCs) with potential interest as #DrugTarget www.nature.com/articles/s44... @PatrickSeale11 #SingleCell #AtheroscleroticPlaque #TranslationalScience