An overview of the molecular #Pathogenesis of #Osteoarthritis, detailing the signaling pathways involved and highlighting emerging therapeutic strategies that ameliorate both #CartilageDegradation and clinical manifestations of OA.

#OpenAccess: doi.org/10.1038/s413...

Combined Analysis of Single Cell and Spatial Transcriptome Reveals Regulation of Anti-human TREM2 Agonist Monoclonal Antibody on the Functional Status of Microglia and Identification of Key Subsets an... Announcing a new article publication for BIO Integration journal. Alzheimer’s disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. Microglia, as central nervous sy...

This study provides a new perspective for elucidating the #pathogenesis of #Alzheimersdisease and also establishes a foundation for the development of precise treatment strategies, offering multiple possibilities for clinical translation.

#OpenAccess: bio-integration.org/alzheimers-d...

#Pathogenesis of #H5N1 Clade 2.3.4.4b in dry Jersey #cows following intramammary inoculation shows within-host compartmentalization

#Pathogenesis of #H5N1 Clade 2.3.4.4b in dry Jersey #cows following intramammary inoculation shows within-host compartmentalization, etidiohnew.blogspot.com/2026/03/path...

This review summarizes the significance of different small noncoding RNAs (#sncRNAs) in #CardiovascularDisease #Pathogenesis, detailing their regulatory roles and potential applications as #Biomarkers & #TherapeuticTargets.
#OpenAccess: doi.org/10.1016/j.ge...

HtrA’s chaperone and proteolytic activities are crucial for H. pylori survival and infection — making it a promising #DrugTarget. This review summarizes HtrA structure and function, its role in #infection and #pathogenesis, and the challenges of its therapeutic targeting 💊

doi.org/10.1002/1873...

Introducing RMzyme, a #Multiomics platform mapping RNA-modifying enzymes across 63 human tissues to elucidate how #Epitranscriptomic regulation and PTM networks drive cellular function and disease #Pathogenesis.

#STTT #OpenAccess: doi.org/10.1038/s413...

This review explores how #HistoneDeacetylases regulate #VascularHomeostasis via endothelial and smooth muscle cells, highlighting their role in vascular #Pathogenesis and the therapeutic potential of #HDACinhibitors.

#OpenAccess: doi.org/10.1016/j.ge...

Establishment and characterization of a novel cell line from Culex tritaeniorhynchus for arbovirus and arthropod-specific virus research

Researchers establish CtrE1, a highly susceptible and genetically tractable stable cell line derived from Culex tritaeniorhynchus, for investigating the replication kinetics & #Pathogenesis of major #Arboviruses & arthropod-specific viruses.
#OpenAccess: doi.org/10.1016/j.dc...

Quantitative framework for pathogen threat assessment based on structural and biochemical features: lack of D-amino acid usage, coherent fractal morphology, and Hz-level oscillations.
@NIH @CDCgov @WHO @NIAIDNews @NatureMicrobiol #Pathogenesis #SystemsBiology #FractalBiology

doi.org/10.1016/j.bi...

Transfer RNA-derived small RNAs (tsRNAs): A rising star in liquid biopsy

This review characterizes tsRNAs as high-potential #Biomarkers for #LiquidBiopsy, detailing their biogenesis and stability in biofluids, their roles in disease #Pathogenesis, and their application as non-invasive biomarkers.
#OpenAccess: doi.org/10.1016/j.ge...

Insights into the interplay between #ERstress & necroptosis, detailing the regulatory role of UPR in the #Pathogenesis of necroptosis-related diseases, & the therapeutic potential of targeting UPR-mediated pathways.

#OpenAccess: doi.org/10.1016/j.ge...

Reviewing the structures, functions, and the molecular mechanisms through which FXYD proteins regulate ion transport, while highlighting their roles in the #Pathogenesis of various diseases and their therapeutic potential.

#OpenAccess: doi.org/10.1016/j.ge...

Decoding the host-pathogen-environment interaction: Integrated insights into Helicobacter pylori virulence and epidemiological transmission

By integrating insights into bacterial virulence and host-environment interactions, this study provides a multi-dimensional framework for understanding H. pylori #Pathogenesis and its evolving epidemiological profile.

#OpenAccess: doi.org/10.1016/j.dc...

which allows these B cells to survive .Once rescued, these B cells initiate inflammatory demyelination through B cell-receptor or antibody-dependent mechanisms & participate in inflammatory demyelination
#Bcells are implicated in the #pathogenesis of MS,

Now available on demand! 🍄 Fungal Pathogens: Emerging Threats & Future Challenges
Watch from anywhere and explore the latest insights in fungal pathogenesis and infectious diseases.

👉 Purchase today: keysym.us/KSFungalPath...

#KSFungalPath26 #FungalPathogens #InfectiousDiseases #Pathogenesis

Decoding the host-pathogen-environment interaction: Integrated insights into Helicobacter pylori virulence and epidemiological transmission

This review explores the mechanisms of #Hpylori #Pathogenesis, the host and environmental factors influencing its #Virulence, and its primary transmission routes to provide insights into its #Diagnosis and prevention. #MedSky

#OpenAccess: doi.org/10.1016/j.dc...

#Pathogenesis and #Research #Models of Acute #Influenza-Associated #Encephalitis / #Encephalopathy: An Update

#Pathogenesis and #Research #Models of Acute #Influenza-Associated #Encephalitis / #Encephalopathy: An Update, etidiohnew.blogspot.com/2026/01/path...

New study reveals a high-resolution genetic map of how E. coli adapts to the gut, showing diet- and inflammation-dependent metabolism, niche shifts, and unexpected roles for mobile genetic elements.

✍️ @amandinemaire.bsky.social & coll.
📖 shorturl.at/DYSTv

#Microbiome #Pathogenesis #Microsky

Atrial fibrillation: from pathogenesis to novel treatment options - Molecular Biomedicine The management of atrial fibrillation (AF) is currently undergoing a significant paradigm shift, driven by a deepening understanding of pathophysiology and the urgent need to overcome the inherent saf...

#Research
Atrial fibrillation: from pathogenesis to novel treatment options doi.org/10.1186/s435...

#AtrialFibrillation #AF #Pathogenesis #CryoballoonAblation #PulmonaryVeinIsolation #PVI #Pulsed_fieldAblation #PFA

Basic Science and Pathogenesis.
Eberlin, Livia Schiavinato et al.
Paper
Details
#BasicScience #Pathogenesis #EberlinResearch

This review on #GATA6 elucidates its crucial role in pancreatic physiology and its involvement in #PancreaticDuctalAdenocarcinoma #Pathogenesis, while highlighting it as a potential #Biomarker & #TherapeuticTarget.

#OpenAccess: doi.org/10.1016/j.ge...

Pathogenesis, Host Resistance and Integrated Management of Sugarcane Smut Caused by Sporisorium scitamineum: A Comprehensive Review Sugarcane smut, caused by the fungus Sporisorium scitamineum, is a devastating disease that threatens sugar production, leading to significant yield losses. The pathogen disrupts sugarcane growth by forming whip‐like structures filled with ...

Pathogenesis, Host Resistance and Integrated Management of Sugarcane Smut Caused by Sporisorium scitamineum: A Comprehensive Review

#diseasemanagement
#hostresistance
#multi‐omics
#pathogenesis
#Sporisorium
#sugarcane

pmc.ncbi.nlm.nih.gov/articles/PMC...

Alcohol‐Related Liver Disease and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Molecular Pathogenesis and Therapeutic Interventions Alcohol-related (ALD) and metabolic dysfunction-associated (MASLD) steatotic liver disease, while initiated by distinct etiologies (ethanol vs. metabolic stress), converge on shared core pathogenic p...

#Review in #MedComm
Alcohol-Related Liver Disease and #Metabolic Dysfunction-Associated Steatotic Liver Disease: Molecular #Pathogenesis and Therapeutic Interventions doi.org/10.1002/mco2...

#ALD #ImmuneRegulation #IntestinalMicrobiota #MASLD

This review discusses #MitochondrialDysfunction in #ParkinsonsDisease (PD), its molecular mechanisms, and the role of mitochondrial dysfunction in aging microglia and astrocytes in PD #Pathogenesis, highlighting future research directions.

#OpenAccess: doi.org/10.1016/j.ge...

A review on m6A methylation regulation & its biological functions in the #ImmuneSystem, detailing its critical role in the #Pathogenesis of #AutoimmuneDiseases, identifying potential #Biomarkers & targets for their prevention & treatment.

#OpenAccess: doi.org/10.1016/j.ge...

An overview of the #Epidemiology of #SystemicLupusErythematosus, key determinants of its #Pathogenesis, diagnosis characteristics, risk factors, and current preventive/therapeutic strategies. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Nutrient Acquisition Drives Edwardsiella tarda Pathogenesis in Necrotizing Soft Tissue Infection
Akeda, Y. et al.
Paper
Details
#Pathogenesis #InfectiousDisease #EdwardsiellaTarda

A comprehensive overview of the structure and function of #MolecularChaperones, their physiological mechanisms, and their roles in disease #pathogenesis, with insights into strategies targeting chaperone systems. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

An overview of lysophosphatidic acid signaling, its role in physiology & #Pathogenesis of various diseases, #Diagnostic & therapeutic potential, and how AI models enable predictive simulation for precision medicine.

#STTT #FeaturedArticle #OpenAccess: doi.org/10.1038/s413...