Effective Agrobacterium-mediated genetic transformation of okra (Abelmoschus esculentus L.) and generation of RNAi plants resistant to Begomovirus infecting okra Okra is an important vegetable crop of the Malvaceae family and is infected by varying numbers of viruses of the genus Begomovirus. Regardless of the importance of the crop, very little considerati...

Effective Agrobacterium-mediated genetic transformation of #okra (#Abelmoschus esculentus) and generation of #RNAi plants resistant to #Begomovirus.
To rediscover one of our most read articles in JHSB 99:2, visit: doi.org/10.1080/1462...

#Agrobacterium

TcALS knockdown accelerates metamorphosis via insulin signaling in Tribolium castaneum #OpenAccess #RNAi #metamorphosis
onlinelibrary.wiley.com/doi/10.1111/...

La vida como científico es sacrificada pero también gratificante. Y a veces gratamente inesperada. Hoy la empresa @alnylampharma.bsky.social experta en terapias #RNAi para #enfermedadesraras inaugura una sala de seminarios en su sede en Madrid a la que ha decidido poner mi nombre. Un inmenso honor.

Silencing of juvenile hormone‐related genes through RNA interference leads to molt failure and high mortality in the spongy moth The feasibility of using RNA interference to control the globally important quarantine pest, the spongy moth. Targeting genes related to JHs play an important role in the growth and development of in...

🏆 2025 Top Downloaded Papers

Silencing of juvenile hormone-related genes through RNA interference leads to molt failure and high mortality in the spongy moth #OpenAccess #RNAi
onlinelibrary.wiley.com/doi/10.1111/...

RNA interference therapies are opening new frontiers in precision genetic medicine. #RNAi #GeneTherapy #Biotechnology www.wiseguyreports.com/fr/reports/r...

🧬 RNAi therapies drive next-gen gene silencing treatments. Explore: www.wiseguyreports.com/ja/reports/r... #RNAi

Funding will take startup through IND-enabling studies of RNAi programs targeting diseases including Alzheimer’s and Parkinson’s.

vist.ly/4qxtk

#longevity #investment #biotech #RNAi #Alzheimers #Parkinsons

Deal takeaways - Strong platform validation for Shengyin’s RNAi chemistry and delivery technologies - Meaningful non-dilutive capital with retained upside via milestones and royalties - Genentech assumes late-stage development and commercialization risk, a classic risk-sharing structure - Signals continued Big Pharma appetite for RNAi assets, especially platform-driven programs From an investment perspective, this deal highlights how differentiated RNA platforms can command premium economics even at early clinical stages—and how large pharma is selectively re-entering RNAi with improved delivery solutions.

RNAi deal worth watching from an investment lens
SanegeneBio announced a global licensing agreement with Genentech (罗氏公司 Group) for an RNAi therapeutic, featuring $200M upfront, up to $1.5B in milestones, plus tiered royalties.
#BiotechInvesting #RNAi #LicensingDeals #PharmaBD #Roche #Genentech

Top: FK506-resistant strains isolated from the Mucor circinelloides complex. Phenotypic analysis of FK506-resistant isolates in Mucor janssenii CBS185.68 (PS1), Mucor bainieri CBS293.63 (PS3), and Mucor atramentarius CBS202.28 (PS6). WT, wild-type; M, mendelian mutant; E, epimutant. Bottom: Schematic overview of epigenetic silencing contributing to antifungal resistance in Mucor species. fkbA expression enables FKBP12 production and FK506 sensitivity (yeast-like morphology). Epigenetic silencing of fkbA via RNAi and/or heterochromatin leads to FK506 resistance and hyphal growth. Generated with BioRender.com.

#Antifungal resistance is a global threat, but epigenetic mechanisms drive rapid, reversible adaptation in fungi. This study shows that #RNAi or #heterochromatin driven #epimutations transiently silence the gene fkbA to confer FK506 #tacrolimus resistance in #Mucor @plosbiology.org 🧪 plos.io/4qdttWc

Top: FK506-resistant strains isolated from the Mucor circinelloides complex. Phenotypic analysis of FK506-resistant isolates in Mucor janssenii CBS185.68 (PS1), Mucor bainieri CBS293.63 (PS3), and Mucor atramentarius CBS202.28 (PS6). WT, wild-type; M, mendelian mutant; E, epimutant. Bottom: Schematic overview of epigenetic silencing contributing to antifungal resistance in Mucor species. fkbA expression enables FKBP12 production and FK506 sensitivity (yeast-like morphology). Epigenetic silencing of fkbA via RNAi and/or heterochromatin leads to FK506 resistance and hyphal growth. Generated with BioRender.com.

#Antifungal resistance is a global threat, but epigenetic mechanisms drive rapid, reversible adaptation in fungi. This study shows that #RNAi or #heterochromatin driven #epimutations transiently silence the gene fkbA to confer FK506 #tacrolimus resistance in #Mucor @plosbiology.org 🧪 plos.io/4qdttWc

Top: FK506-resistant strains isolated from the Mucor circinelloides complex. Phenotypic analysis of FK506-resistant isolates in Mucor janssenii CBS185.68 (PS1), Mucor bainieri CBS293.63 (PS3), and Mucor atramentarius CBS202.28 (PS6). WT, wild-type; M, mendelian mutant; E, epimutant. Bottom: Schematic overview of epigenetic silencing contributing to antifungal resistance in Mucor species. fkbA expression enables FKBP12 production and FK506 sensitivity (yeast-like morphology). Epigenetic silencing of fkbA via RNAi and/or heterochromatin leads to FK506 resistance and hyphal growth. Generated with BioRender.com.

#Antifungal resistance is a global threat, but epigenetic mechanisms drive rapid, reversible adaptation in fungi. This study shows that #RNAi or #heterochromatin driven #epimutations transiently silence the gene fkbA to confer FK506 #tacrolimus resistance in #Mucor @plosbiology.org 🧪 plos.io/4qdttWc

Areca palm velarivirus 1 encoded CP suppresses antiviral RNA silencing by mediating the autophagic degradation of SGS3 and disrupting the SGS3–RDR6 interaction - Stress Biology Areca palm velarivirus 1 (APV1) is the causative agent of yellow leaf disease (YLD), leading to severe yield losses in areca palms. However, how APV1 counteracts host immunity remains largely underexp...

Areca palm velarivirus 1 encoded CP suppresses antiviral RNA silencing by mediating the autophagic degradation of SGS3 and disrupting the SGS3–RDR6 interaction

Jiawei Wen, Huili Li … Xianmei Cao, Xi Huang

link.springer.com/article/10.1...

#Autophagic #HostAntiviral #RNAi #Nicotiana

Next-generation biopesticide uses RNAi yeast and sugar lures to target fruit fly pest - Farming Future Food U.S. researchers have used RNA interference to engineer yeast that selectively kills spotted wing drosophila when delivered in a sugar bait, offering a potential new class of biorational insecticides.

There are few successful or sustainable ways to tackle the spotted wing drosophila, a notorious #fruit pest, but delivering #RNAi interference via yeast (and some Coca-Cola) looks very promising.

farmingfuturefood.com/next-generat...

#farming #agritech #genetics #scicomm

Breakthrough gene-silencing therapies are accelerating the RNAi Technology Market. Explore biotech trends! www.marketresearchfuture.com/reports/rnai...
#RNAi #GeneTherapy #Biotechnology

dsRNA injection to N. vectensis zygotes triggers mild and transient gene knockdown. Top: Schematic representation of the dsRNA carrying eGFP sequence used in this study and of the transgene of the actin::eGFP line [40]. Bottom left: Heterozygous actin::eGFP embryos showing dimmer eGFP fluorescence 24 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm. Bottom right: No difference in eGFP fluorescence of heterozygous actin::eGFP embryos is exhibited 72 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm.

#RNAi is an ancestral #antiviral system that degrades viral RNA, but what about in #cnidarians? @yehumoran.bsky.social &co show that #Nematostella has an siRNA-mediated antiviral response that lacks 2ary amplification & functions as a short-term antiviral mechanism @plosbiology.org 🧪 plos.io/3N192OD

Proud moment for City: We’ve been named to BioSpace’s NextGen Class of 2026, recognizing top up-and-coming #lifescience companies in North America. We’re grateful for the recognition and proud of our team pushing innovative #RNAi therapeutics. www.biospace.com/nextgen

dsRNA injection to N. vectensis zygotes triggers mild and transient gene knockdown. Top: Schematic representation of the dsRNA carrying eGFP sequence used in this study and of the transgene of the actin::eGFP line [40]. Bottom left: Heterozygous actin::eGFP embryos showing dimmer eGFP fluorescence 24 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm. Bottom right: No difference in eGFP fluorescence of heterozygous actin::eGFP embryos is exhibited 72 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm.

#RNAi is an ancestral #antiviral system that degrades viral RNA, but what about in #cnidarians? @yehumoran.bsky.social &co show that #Nematostella has an siRNA-mediated antiviral response that lacks 2ary amplification & functions as a short-term antiviral mechanism @plosbiology.org 🧪 plos.io/3N192OD

dsRNA injection to N. vectensis zygotes triggers mild and transient gene knockdown. Top: Schematic representation of the dsRNA carrying eGFP sequence used in this study and of the transgene of the actin::eGFP line [40]. Bottom left: Heterozygous actin::eGFP embryos showing dimmer eGFP fluorescence 24 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm. Bottom right: No difference in eGFP fluorescence of heterozygous actin::eGFP embryos is exhibited 72 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm.

#RNAi is an ancestral #antiviral system that degrades viral RNA, but what about in #cnidarians? @yehumoran.bsky.social &co show that #Nematostella has an siRNA-mediated antiviral response that lacks 2ary amplification & functions as a short-term antiviral mechanism @plosbiology.org 🧪 plos.io/3N192OD

Characterization of RNA interference in the cnidarian Nematostella vectensis reveals partial target silencing but lack of small RNA amplification RNA interference is an ancestral antiviral mechanism that degrades viral RNA through siRNAs, but its role in cnidarians has been unclear. This study shows that Nematostella vectensis likely possesses ...

1/3 🚨New paper from our lab!🔥
Most textbooks will tell you that invertebrates employ #RNAi as antiviral mechanism. Yet, do 🪸🪼 actually do it? Well, the answer is complicated. We show that in #Nematostella dsRNA induces RNAi 🧵
journals.plos.org/plosbiology/...

Over the past few weeks, TRAMA students have been working in the @geneticsub.bsky.social laboratory with the C. elegans model, exploring how mutations, #RNAi, and genetic editing with #CRISPR work.
📷 Image of this year’s course students

New research in #RESInsectMolecBio

Kr-h1 is vital for #vitellogenesis in two ladybird beetle species
doi.org/10.1111/imb.70022

#Henosepilachna #RNAi #Krh1
@sassanasgari.bsky.social @gulianusslab.bsky.social @wileyeco.bsky.social

FDA approval, Breakthrough Therapy status and an early Alzheimer’s trial reshape Arrowhead Pharmaceuticals’ outlook.

longevity.technology/news/arrowhe...

#longevity #biotech #RNAi #PharmaInnovation #HealthcareInvesting #BiotechStocks #DrugDiscovery #PrecisionMedicine #FDAApproval

A seminar room filled with students and researchers seated and listening to a scientific talk. A speaker stands at the front of the room beside a projected presentation slide.

Many thanks to Peter Brodersen (University of Copenhagen) for an excellent talk on “A proxy #RNAi pathway for sensing pathogenic cytoplasmic double-stranded RNA in #plants.” It was a pleasure to have you with us!

Thanks as well to @claudiakohler11.bsky.social for hosting the talk.

Recurrent expansion and rapid evolution of the Drosophilid RNAi pathway in testis Multiple classes of selfish genetic elements, including transposable elements, meiotic drivers, and viruses, are suppressed by small interfering RNAs (siRNAs) that guide RNA interference (RNAi). These...

#RNAi #Drosophila #Testis #Evolution www.biorxiv.org/content/10.1...

«Ha estat un èxit sense precedents, una oportunitat única per a molts dels nostres alumnes, doctorands, investigadors i professors, que han pogut interactuar amb el professor Mello i compartir els seus coneixements i recomanacions (...)» diu el degà Dr. Trilla sobre la visita.

#NobelPrize #RNAi

SanegeneBio and Eli Lilly Unite in Groundbreaking RNAi Research Collaboration SanegeneBio partners with Eli Lilly to develop innovative RNAi therapeutics targeting metabolic diseases, leveraging advanced LEAD™ technology.

SanegeneBio and Eli Lilly Unite in Groundbreaking RNAi Research Collaboration #USA #Boston #Lilly #RNAi #SanegeneBio

MicroRNA‐Induced Gene Silencing (MIGS): A Tool for Multi‐Gene Silencing and Targeting Viruses in Plants Since its discovery, RNA interference (RNAi, also known as gene silencing) has been a key tool to downregulate gene expression in plants for a range of applications, including protection against viru....

📢 New publication 'MicroRNA-Induced Gene Silencing ( #MIGS): A Tool for Multi-Gene Silencing and Targeting Viruses in Plants' by Marie-Emilie Gauthier et al. in Plant Biotechnology Journal 🧬🧪

#RNAi #GeneSilencing

doi.org/10.1111/pbi....

New product seeks to reverse honeybee colony collapse The Environmental Protection Agency gave approval earlier in 2025 to a new mode of action miticide to control the varroa mite.

www.farmprogress.com/insects/new-... #honeybees #RNAi #biopesticides

Joined University of Gothenburg as a Principal Investigator (PI). With that I begin an independent journey in #RNAthereapeutics and #extracellularvesicles

#Exosomes
#Lipidnanopartivles
#RNA
#mRNA
#RNAi
#siRNA