#RNAbiology #SpatialGeneExpression #RNAlocalization #Cellcycle #SpatialBio

Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation Development of LOV-domain-controlled ligase for translation localization (LOCL-TL), an optogenetic approach for monitoring translation with codon resolution at any defined subcellular location under p...

#RNAbiology #RNAlocalization #LocalizedTransaltion
www.cell.com/cell/fulltex...

Control of epithelial tissue organization by mRNA localization - Nature Communications Subcellular mRNA localization is prevalent but with poorly understood physiological roles. Here, the authors show that Net1 mRNA targeting to the basement membrane controls epithelial tissue organizat...

This one is close to my scientific heart 💜:
An excellent read shining the light on an aspect of RNA biology that is way too often overlooked.
#RNAsky #RNAlocalization

Axonal RNA localization is essential for long-term memory - Nature Communications Axonal transcriptomes have been characterized, but their regulation and role in neuronal circuits remain unclear. Here authors uncover activity-dependent RNA localization in axons important for memory...

From the Besse's lab.
#RNAbiology #RNAlocalization #spatialbiology

www.nature.com/articles/s41...

Decoding subcellular RNA localization one molecule at a time - Genome Biology Eukaryotic cells are highly structured and composed of multiple membrane-bound and membraneless organelles. Subcellular RNA localization is a critical regulator of RNA function, influencing various bi...

Excited to share our lab’s first review, focusing on RNA localization! #RNA #RNAlocalization genomebiology.biomedcentral.com/articles/10....

This is a very good read! Nice to have an updated overview of the #RNAlocalization field every now and then. The schemes are also beautiful!
#RNA , #RNAsky

Phosphorylation of a nuclear condensate regulates cohesion and mRNA retention - Nature Communications Here the authors study how interactions with nuclear speckles help localize mRNA in cells. They find that modifications of the proteins in these structures affects their cohesion and can modulate mRNA...

Phosphorylation of a nuclear condensate regulates cohesion and mRNA retention
#RNAbiology #RNAlocalization

www.nature.com/articles/s41...

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription
#RNAbiology #RNAlocalization

www.cell.com/molecular-ce...