⏪ G&D RECAP ⏪

🗓️ December 2025
RESEARCH PAPER: Multiple human enhancer RNAs contain long translated open reading frames
By Vlasov et al. and James Manley
➡️ https://genesdev.cshlp.org/content/39/23-24/1468.full

#protein #translation #enhancerRNA #chromatin #DNAdamage #RNAprocessing #nucleus

⏪ G&D RECAP ⏪

🗓️ November 2025
OUTLOOK: End of the line: a kinetic ruler model for poly(A) tail termination
By Anita Corbett
➡️ https://genesdev.cshlp.org/content/39/21-22/1267.full

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full

#RNAprocessing #mRNA #ribonucleoprotein

⏪ G&D RECAP ⏪

🗓️ November 2025
RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full

#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC

RESEARCH PAPER: Multiple human enhancer RNAs contain long translated open reading frames
By Vlasov et al. and James Manley
➡️ https://genesdev.cshlp.org/content/39/23-24/1468.full

#protein #translation #enhancerRNA #openreadingframe #chromatin #DNAdamage #RNAprocessing #nucleus

One of the most intriguing recent RIP works is the development of #MAPITseq, a method to sequence RNA that is actively transcribed in-situ, revealing essential information on #transcription and #RNAProcessing dynamics.

OUTLOOK: End of the line: a kinetic ruler model for poly(A) tail termination
By Anita Corbett
➡️ https://genesdev.cshlp.org/content/39/21-22/1267.full

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full

#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC

RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full

#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC

U01.01.015 Splicing of pre-mRNA Focus on the molecular consequence described in the question — a mutation in the SMN1 gene causing defective snRNP assembly. Recall the cellular processes each component is involved in. Use this analysis to determine which process is directly impaired. This approach strengthens your ability to link gene mutations to cellular dysfunction.

Understand how pre-mRNA becomes mature mRNA through precise splicing. #MolecularBiology #USMLE #Genetics #RNAProcessing #MedicalEducation

A time-resolved framework for the recruitment of mRNP processing and assembly factors to a site of transcription.

Great work by the Montpetit lab!
#RNAbiology #RNAprocessing #mRNP
doi.org/10.1093/nar/...

🧬 New paper!
Identification of novel substrates of the Lon1 protease and its role in PPR-mediated RNA processing in Arabidopsis mitochondria 🌿
A fresh look at how Lon1 orchestrates mitochondrial gene expression.
#PlantScience #Mitochondria #Arabidopsis #PPR #RNAprocessing #Proteomics #Lon1

Single-molecule multimodal timing of in vivo mRNA synthesis mRNA synthesis requires extensive pre-mRNA maturation, the organisation of which remains unclear. Here, we directly sequence pre-mRNA without metabolic labelling or amplification to resolve transcript...

"Single-molecule multimodal timing of in vivo mRNA synthesis" a collaboration with Rippei Hayashi's lab, work led by AJ Sethi #RNA #pre-mRNA #splicing #RNAprocessing #m6A #polyadenylation
www.biorxiv.org/content/10.1...

Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency Reprogramming of aged donor tissue cells into induced pluripotent stem cells (A-iPSC) preserved the epigenetic memory of aged-donor tissue, defined as genomic instability and poor tissue differentiati...

Interesting!
#RNAExosome #EXOSC2 #RNADecay #RNAprocessing #Aging #Cancer

www.biorxiv.org/content/10.1...

Post‐Transcriptional Regulation of Gene Expression and the Intricate Life of Eukaryotic mRNAs The central dogma of biology relies on numerous regulatory events to define the expression profile of any given cell. Created in https://BioRender.com.

#GeneExpression #Review #mRNA #RNA #RNAProcessing

wires.onlinelibrary.wiley.com/doi/full/10....

RNA exosome-driven RNA processing instructs the duration of the unfolded protein response Abstract. Upon stresses, cellular compartments initiate adaptive programs meant to restore homeostasis. Dedicated to the resolution of transient perturbati

#RNAExosome #Rrp6 #RNAProcessing #Splicing #UPR #UnfoldedProteinResponse #BuddingYeast

academic.oup.com/nar/article/...

Poster session is up at #semmretreat24 ⭐️ presenting ongoing PhD project focused on how #RNAprocessing is altered upon genomic instability in #colorectal cancers

Really excited to present it to my PhD peers✨✨

Thanks to @semm_it and @ceredalab.bsky.social