Read-Across does not fail because uncertainty exists. It fails when uncertainty is poorly characterised.

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#ReadAcross #ReadAcrossStrategy #REACH #EUREACH #REACHRegulation #REACHRegistration #Toxicology #OECD #EFSA #ECHA #DataGap #CLP

🔬 New study (Mizuno et al., 2026) combining alvaDesc molecular descriptors with mechanism-based in vitro assays to improve read-across prediction of rat thyroid carcinogenicity.

📖 Paper: doi.org/10.1016/j.fc...
🔗 alvaDesc: alvascience.com/alvadesc/

#alvaDesc #ReadAcross #QSAR #NAMs #chemsky

Now published......

𝐄𝐧𝐯𝐢𝐫𝐨𝐧. 𝐒𝐜𝐢.: 𝐏𝐫𝐨𝐜𝐞𝐬𝐬𝐞𝐬 𝐈𝐦𝐩𝐚𝐜𝐭𝐬, 𝟐𝟎𝟐𝟔 (Environmental #RSCEnv)

doi.org/10.1039/D5EM...

Research funded by DRDO, Ministry of Defence, Govt. of India (LSRB)

#Cheminformatics #Chemometrics #Carcinogenicity #RASAR #QSAR #Readacross #Predictions #MachineLearning

From structure to strategy: chemometric modeling for the prediction of terminal half-life of pharmaceuticals and its role in future therapeutics - Molecular Diversity The terminal half-life ( $$t_{1/2}$$ t 1 / 2 ) is a crucial pharmacokinetic parameter for estimating the dose regimen and duration of action of a drug. Previously, few research papers have been publis...

New study by Samanta et al. shows how q-RASAR + QSAR can predict terminal half-life (t½) for 895 drugs doi.org/10.1007/s110... using 2D descriptors from #alvaDesc.

🔗 Learn more about alvaDesc: alvascience.com/alvadesc/

#QSAR #ReadAcross #Pharmacokinetics #DrugDiscovery

Improving Read-Across Acceptance Under REACH - Lessons from Surfactants.

Why many read-across submissions under REACH fail to gain acceptance by authorities...

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#ReadAcross #REACH #REACHCompliance #ECHA #NAMs #ChemicalCompliance

🔬 New study uses alvaDesc + in vitro data to predict nongenotoxic carcinogenicity of pesticides via read-across.
Balanced accuracy up to 0.82 for rat tumor endpoints. doi.org/10.1016/j.fc...

Check alvaDesc at: alvascience.com/alvadesc/

#QSAR #Toxicology #ReadAcross #NAMs #chemsky

Future-Proofing Nano Risk Assessment: Insights from EFSA’s 2025 Stakeholder Workshop.

Read our summary >> www.bluefrogscientific.com/c...

#Nano #NanoCompliance #NanoRegulation #Nanomaterials #Nanoforms #EFSA #ECHA #ReadAcross #NAMs #SSbD

15 Years of Read-Across Under EU REACH – Lessons from ECHA’s Testing Proposal & Compliance Check Decisions.

Valuable resource for anyone planning to use read-across in future REACH submissions.

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#ReadAcross #ECHA #REACH #ChemicalRegulation

"Join the nation’s largest celebration of reading! Enter the 2021 #ReadAcross America Sweepstakes to win a year’s worth of diverse books for every classroom in your school.

nea.org/read-across-am…