Figure 1 Light and electron microscopy reveal epithelial cell vacuolation in acute tubular injury. (a) Light microscopy shows focal acute tubular injury at the corticomedullary junction, with significant swelling of tubular epithelial cells caused by optically transparent vacuoles. Hematoxylin and eosin staining. Bar = 50 μm. (b) The vacuoles contain periodic acid–Schiff–positive material. Bar = 50 μm. (c) Electron microscopy of paraffin-fixed tissue reveals the outline of tubular epithelial cell membranes, partial cell nuclei, and degenerated organelles, with obvious intracellular cavitation. Bar = 10 μm. To optimize viewing of this image, please see the online version of this article at www.kidney-international.org.

The Armanni-Ebstein (not Epstein😅) lesion in a nondiabetic patient

The glycosuria from flozination can cause these, very interesting phenomenon

www.kidney-international.org/article/S008... in Kidney International

#RenalPath

Registration is still open for the RPS Satellite Meeting and Reception at USCAP 2026 in San Antonio, TX

Drug Therapies: footprints on the kidney
👉https://renalpathsoc.org/event-6567896
RPS RECEPTION AND AWARDS
👉https://renalpathsoc.org/event-6568023
#renalpath #USCAP2026

RPS POSTER WALK at USCAP 2026
#renalpath #USCAP2026
@glombandit.bsky.social

There were also mesangial IgA deposits (Figure 3), which likely explain the patient's hematuria and proteinuria, since there was very little glomerular amyloid (Figure 4).

#renalpath #kidneypath #pathology #renal #pathsky

The stain is a Congo Red viewed under fluorescent light with a red filter. It highlights interstitial amyloid deposits, which is the predominant pattern of deposition in LECT2 amyloidosis (confirmed by IHC stain, Figure 2).

#renalpath #kidneypath #pathology #renal #pathsky

Autolysis versus ATN in an autopsy specimen. Autolytic tubules show detachment of epithelial cells from tubular BM and seem to fall off into the lumen (yellow circle). Rest of tubules with ATN: epithelial cells on the BM but thin + loss of brush borders. #renalpath #pathsky

1/ This electron microscopy shows marked GBM abnormalities, consistent with Alport's Syndrome (AS). The patient had genetic testing, which confirmed a COL4A3 mutation.

#renalpath #kidneypath #pathology #renal

Allograft biopsy for AKI after belatacept conversion. Yikes! Acute cellular rejection grade III with necrotizing arteritis. #renalpath #pathsky #nephsky

Proteomic Profiling of Complement Components in Glomerular Disease - PubMed The complement system plays a central role in glomerular disease development and resolution. Currently, renal biopsies assess the presence of complement through limited immunofluorescence stains (C3 and C1q). With more than 50 total proteins and fragments involved in the complement cascade, this met …

We're excited to share a new research publication from @aaronstorey.bsky.social, @glombandit.bsky.social, and Dr. Chris Larsen titled, "Proteomic Profiling of Complement Components in Glomerular Disease."

Read here: https://pubmed.ncbi.nlm.nih.gov/41720186/
#ArkanaResearch #RenalPath #RenalResearch

Some large KW nodules in this case of diabetic nephropathy. Unfortunately a common occurrence in my biopsy practice. #renalpath #pathsky #nephsky

Another chronic glomerulopathy case. EM stage IV of IV resorbed deposits in a pt with PLA2R+ Membranous nephropathy with persistent proteinuria. #renalpath #pathsky #nephsky

1/ The biopsy shows collapsing glomerulopathy, for which the differential diagnosis in a transplant recipient includes ischemia, calcineurin inhibitor nephrotoxicity, CMV infection, thrombotic microangiopathy, and donor-derived APOL1-associated nephropathy.

#renalpath #kidneypath

Figure 1 Hematoxylin andeosin–stainedrenal biopsy(original magnification ×40) of the patient showingtubulointerstitial nephritis, characterized by a mononuclear inflammatory infiltrate with clusters ofmacrophages containing round intracytoplasmic structures (highlighted by the black circle). The Grocott-stained specimen (see Supplementary Figure S1) revealed intracytoplasmic round structures consistent with Histoplasma capsulatum yeasts. These histologic features supported the diagnosis of interstitial nephritis by Histoplasma spp. (see Supplementary Figure S1 for the differential diagnosis discussion).

Supplementary Figure S1. Grocott-stained specimen demonstrating intracytoplasmic round structures consistent with Histoplasma capsulatum yeasts (indicated by the red arrow). The differential diagnosis with other fungi (such as Cryptococcus, Candida, Blastomyces, and Paracoccidioides) and other intracellular pathogens (such as Toxoplasma, Leishmania, and Trypanosoma) was made based on the following histopathologic features: small size (2–5 μm), round shape, homogeneous intracellular distribution, silver positivity, absence of kinetoplasts, and negative mucicarmine staining—all of which supported the diagnosis of histoplasmosis.

Acute interstitial nephritis from ....histoplasma

www.kidney-international.org/article/S008...

@kidneyint.bsky.social

#NephSky #RenalPath

Recent bxs are so important for clinical trial enrolment. Bx in pt with hx of lupus nephritis (IV+V) with worsening proteinuria. Bx for trial enrollment. Chronic changes only, 0 activity, resorbed deposits by EM, min IF staining. #nephsky #renalpath #Pathsky

USCAP 2026 Lunch Presentation
Discover Important Updates in C3G
Presenter: Anthony Chang, MD
University of Chicago Medical Center
Sunday, March 22nd, 12 - 1 PM CT
No registration required
Lunch provided
@uscap.org @changucanspare.bsky.social
#USCAP2026 #renalpath #pathsky

Bx in older F pt for subnephrotic proteinuria reveals numerous myelin figures in podocytes. Concern for Fabry + other genetic diseases. Subsequently learned the pt was on long term to Plaquenil. Genetics pending, but may all be HCQ tox. #renalpath #pathsky #nephsky

RPS Satellite meeting - Hybrid
Drug Therapies: Footprints on the Kidney
Sunday, March 22nd, 1 - 4 PM CT
In-person: registration available until March 16
Virtual: registration available until March 21
renalpathsoc.org/event-6567896
@uscap.org
#USCAP #renalpath #pathsky #nephsky #nephrology

Polymer Embolization From Minimally Invasive Interventions Many of the tools used in interventional nephrology, such as glidewires and sheaths, are coated with a hydrophilic polymer to increase their lubricity…

The PAS-stain picture depicts gray and basophilic amorphous material within glomerular capillaries, consistent with polymer emboli. The patient had undergone renal transplant artery angioplasty a few months earlier.

Reference: www.sciencedirect.com/science/arti...

#renalpath #pathology

Amyloid spicules, so-called "eyelashes", as they lay down perpendicularly along the glomerular basement membrane.  #UnderTheScope #renalpath #pathsky

The Oxford Classification Should Remain the Gold Standard for Classification of IgA Nephropathy
journals.lww.com/kidney360/ci...

#renalpath #pathsky #nephsky #nephrology

Oxalate Nephropathy & Renal Embolic Disease Collision Case | Collidescope Episode 10 Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

What happens when oxalate nephropathy & renal embolic disease interact? How does this interaction impact kidney function? Find out the answer in our latest #Collidescope episode!

#renalpath #kidneypath #pathsky #renalsky

Oxalate Nephropathy & Renal Embolic Disease Collision Case | Collidescope Episode 10 Nyd de videoer og den musik, du holder af, upload originalt indhold, og del det hele med venner, familie og verden på YouTube.

In this week's #Collidescope case, Dr. Charles investigates a case of oxalate nephropathy & renal embolic disease. Watch the episode to learn more about how these two diseases interact and affect kidney function. 

#renalpath #kidneypath #pathsky #renalsky

Nephrocalcinosis secondary to a parathyroid adenoma

doi.org/10.1016/j.kint.2025.07.030

#NephSky #MedSky #AKI #kidneybiopsy #renalpath #kidneypath

Oxalate Nephropathy & Renal Embolic Disease Collision Case | Collidescope Episode 10 Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

What happens when oxalate nephropathy & renal embolic disease interact? How does this interaction impact kidney function? Find out the answer in our latest #Collidescope episode!

#renalpath #kidneypath #pathsky #renalsky

Oxalate & Renal Embolic Disease Collision Case | Collidescope Episode 10 Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

Dr. Charles is back with another #Collidescope case! Learn about how oxalate & renal embolic disease interact and affect kidney function! #renalpath #kidneypath #pathsky #renalsky

The biopsy shows linear IgG staining along the GBM, and extensive fibrinogen staining within the Bowman space, consistent with crescent formation. These findings are diagnostic of anti-GBM disease.

#renalpath #kidneypath #pathology #renal

Somewhat subtle case of light chain cast nephropathy by LM. Mostly fine granular casts. Rare PAS pale + two toned color casts. No cellular reaction. IF with K restricted casts confirmatory. EM demonstrates LC precipitation with uromodulin. #renalpath #nephsky #pathsky

Interesting case of necrotizing vasculitis in a lupus patient. Hx of LN in prior biopsies, no active GN features now. May be lupus vasculitis, but recommend r/o superimposed vasculitic disease (e.g., ANCA, drugs) with such biopsies findings. #renalpath #nephsky #pathsky

Tumor nephrectomy with incidental ALECT2. Interestingly this was from a pt from India. Reminder that a subset of ALECT2 cases have been reported in Punjabi patients (pubmed.ncbi.nlm.nih.gov/35986199/) . #renalpath #pathsky #nephsky

Leucocyte tickling a tubular epithelial cells in a case of cellular rejection in a txp biopsy. Can anyone with more immunology knowledge than me explain what is happening here? #renalpath #nephsky #pathsky