SimThyr 2.0 on a Mac SE with Mac OS Antares 6.0.7 (left) and SimThyr 4.0.6 on a MacBook Air with macOS Ventura 13.7 (right)

30 years of #SimThyr in #Marchintosh 2026: #SimThyr 2.0 on a Mac SE with Mac OS Antares 6.0.7 and SimThyr 4.0.6 on a MacBook Air with macOS Ventura 13.7.

Thanks to the fact that the code was based on the #Pascal programming language, the software is highly portable, but runs with full native speed.

#SimulaBeta and #SimThyr provide the theoretical foundations for this revolutionary approach.

#SimThyr is a well-accepted Pascal program that has been used in multiple scientific projects. It continues to be developed further.

#SimThyr helps to lift our understanding of thyroid homeostasis to a higher level.

Figure from the book "Hypothyroidism: A Paradigm Shift" by Hoermann and Dietrich: Combination of peripheral and central mechanisms leading to the low-T3 syndrome. The activities of peripheral (GD1) and central (GD2) deiodinases diverge to cause the low-T3 phenotype. The graph shown has been produced by computer simulation with the free app SimThyr.

Computer simulations with #SimThyr enhance our understanding of the physiology of hypothalamic-pituitary-thyroid feedback control. This applies, for example, to the evolution of #TACITUS syndrome.

#thyroid #hypothyroidism #NTIS #biocybernetics

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