This #STTT review outlines the advanced engineering and combination strategies for #OncolyticViruses to enhance their ability to selectively lyse #MalignantCells and reprogram the #TumorMicroenvironment for #SystemicImmunity.

#OpenAccess: doi.org/10.1038/s413...

Single-cell RNA-seq reveals cell type-specific molecular and genetic associations with primary open-angle glaucoma - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Single-cell RNA-seq reveals cell type-specific molecular and genetic associations with primary open-angle glaucoma

Researchers map #SystemicImmunity in #POAG via #SingleCellRNASeq of #PBMCs, revealing increased CD4+ T cells, impaired cytolytic potential, and a dual proinflammatory/neuroprotective landscape, linking immune dysregulation to #retinal health.

#OpenAccess #STTT: doi.org/10.1038/s413...