HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung Tertiary lymphoid structures are critical components of tissue immunity, necessitating better understanding of their organization and immune functions. De Lima et al. investigate the spatial and tempo...

Excited to share our work published in @cp-immunity.bsky.social! We investigated the role of HIF-1α in CD4 T cells using #Xenium spatial transcriptomics in infected lungs containing #TertiaryLymphoidStructures (TLS) (1/10).

www.cell.com/immunity/ful...

Hidden immune “hubs” drive joint damage in rheumatoid arthritis – BioNews Central New research shows that peripheral helper T (Tph) cells in rheumatoid arthritis include stem-like Tph cells that reside in joint tertiary lymphoid structures and give rise to effector Tph cells that exit those structures and drive inflammation—sugges

New research shows that peripheral #HelperTCells (Tph cells) in #RheumatoidArthritis include stem-like Tph cells that reside in joint #TertiaryLymphoidStructures and give rise to effector Tph cells that drive #inflammation—suggesting that targeting stem-like Tph cells could improve treatment. 

Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer Osorio et al. report a first-in-human study of intratumoral 2141-V11, an Fc-engineered CD40 agonistic antibody, showing it is safe and induces systemic and durable antitumor immunity in patients with ...

#cancersky #immunosky #antibodysky

Major #CD40 #TherapeuticAntibody Success now breaking
@cp-cancercell.bsky.social

First-in-Human study of Fc-optimised CD40 agonistic Antibody elicits #TertiaryLymphoidStructures & systemic anti-Tumor #Immunity in Metastatic #Cancer

Fantastic work 👏

We discuss how #tumour's #spatialweb supports T cells or causes #dysfunction/#exclusion e.g., supportive #perivascular or pro-#immunogenic/#antigenic niches & #tertiarylymphoidstructures vs. #hypoxic cores, #wound #healing & #myeloid, #stromal or #fibroblastic #barriers. 4/6🧵

#ImmunoSky

#Immunotherapy
#ImmuneRelatedAdverseEvents
#Biomarkers

#ICOS+ CD4 #Tcells define #Susceptibility to anti-PD1-induced #Lung #Pathology in the #Aged

#Bcells #Antibodies #TertiaryLymphoidStructures

Breaking Open Access Study @jci-insight.bsky.social

insight.jci.org/articles/vie...

Featured today by @MSKLibrary: IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer

#IL33 #ILC2 #TertiaryLymphoidStructures #PancreaticCancer #CancerImmunology

www.nature.com/articles/s41...