Female-specific Cx3cr1-driven regulation of #ALS and #Alzheimer’s risk genes in #tauopathy

Ari Sudwarts & Gopal Thinakaran @thinakaran.bsky.social #microglia #transcriptome

link.springer.com/article/10.1...

Join the local Melbourne #illumina Field Apps team to specialise in #Bioinformatics. It's a great team, you get to play with #DRAGEN and help customers get the best data for analysis. #genomics #multiomics #singlecell #spatial #transcriptome #epigenetics bit.ly/46o4sRj
I can refer the right folks.

Defining expansions and perturbations to the RNA polymerase III transcriptome and epitranscriptome by modified direct RNA nanopore sequencing - Nature Communications RNA polymerase III transcribes essential non-coding RNAs, but many aspects of this biology remain unclear. Here, the authors develop DRAP3R, a nanopore sequencing method that captures Pol III transcripts and RNA modifications, revealing new RNAs and dynamic modification patterns.

New paper uses a modified direct #RNA #nanopore sequencing framework (DRAP3R) to reveal expanded RNA polymerase III #transcriptome and epitranscriptome landscapes, including novel Pol III-transcribed RNAs. 🧬
📄 https://doi.org/10.1038/s41467-025-68230-1
👤 EVBC member: Daniel Depledge

New preprint out! We made a #Plasmodium knowlesi A1-H.1 #transcriptome time course for asexual blood stages🩸. tinyurl.com/mwd9b8vx
👩‍💻Webtool to compare temporal expression to P. vivax: tinyurl.com/bdz2ndsj

@itmantwerp.bsky.social @eknuepfer.bsky.social @cortesmalaria.bsky.social

Latest in #G3journal: A newly assembled de novo #transcriptome assembly from brain samples of Dryophytes arenicolor—a Canyon Treefrog—across different life stages identifies novel putative long non-coding RNAs (lncRNAs). buff.ly/RnGDZiO

A genetically encoded device for transcriptome storage in mammalian cells Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...

🧬🔬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org

New research in #RESMedVetEnt

Transposable elements in the #transcriptome of #Aedes (Stegomyia) aegypti (Linnaeus, 1762)
doi.org/10.1111/mve.70040

#TransposableElements #InsectVectors #VectorControl
@wileyeco.bsky.social

#JJC2026 Mathieu Delaeter (ULCO) on unravelling how #mycorrhizal inoculation shapes the #wheat foliar #transcriptome and enhances #resistance to #septoria tritici blotch

Genomic Crosstalk Between Nuclear Receptors in Hormone-dependent Cancers Abstract. Nuclear receptors (NRs) orchestrate transcriptional programs that regulate cell fate decisions, and when these processes are disrupted, they can

Genomic Crosstalk Between Nuclear Receptors in Hormone-dependent Cancers. Read more in #Endocrinology: bit.ly/4aiWdJ5 #NuclearReceptors #Cistrome #Transcriptome @endocrinesociety.bsky.social

Dear #spatial #transcriptome scientists, what would be an R based package/pipeline/function suggestion of yours regarding cell/trx niche determination after RCTD deconvolution?

Choline attenuates NEFA-induced hepatic steatosis via GNMT regulation in hepatocytes - Stress Biology To elucidate the molecular mechanisms by which choline regulates hepatic lipid metabolism under negative energy balance conditions, we established non-esterified fatty acid (NEFA)-induced hepatic stea...

Choline attenuates NEFA-induced hepatic steatosis via GNMT regulation in hepatocytes
Xueer Du, Lamei Wang ... Jianguo Wang, Yangchun Cao

link.springer.com/article/10.1...

#transcriptome #cow #animalscience

Open Public Resource in R2: The RNA Atlas, the most complete #mRNA resource assessed in 300 tissues / cell types. Explore it for yourself at:

r2platform.com/rna_atlas/

#science #Datavisualization #transcriptome #ncRNA

Researchers establish a full-length #gallbladder #transcriptome atlas using #LongReadSequencing and identify ERBB2 i14e as a novel isoform driving #TumorGrowth and trastuzumab resistance. #ERBB2 #antisense #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Open Public Resource in R2: The RNA Atlas, the most complete #mRNA resource assessed in 300 tissues / cell types. Explore it for yourself at:

r2platform.com/rna_atlas/

#science #Datavisualization #transcriptome #ncRNA

Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches - GeroScience The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has introduced the medical community to the phenomenon of long COVID, a condition characterized by persistent symptoms following the resolution o...

www.croiconference.org/wp-content/u...

link.springer.com/article/10.1...

www.sciencedirect.com/science/arti...

www.cell.com/molecular-th...
This study demonstrated significant #transcriptome differences in mononuclear cells & granulocytes between no known #COVID, acute COVID, COVID recovered,

New wheat diversity discovery could provide an urgently-needed solution to global food security Newly-discovered diversity in the wheat genome could offer vital new opportunities to improve and ‘climate-proof’ one of the world’s most important staple crops.

💬 “The new expression atlas allowed us to independently predict and compare the gene content of the wheat cultivars."

🌾 Scientists have published the first wheat pan-transcriptome to reveal layers of hidden diversity spanning our modern #wheat variations.

💻🧬 #geneexpression #transcriptome #genesky

Pooled #CRISPR screens with joint single-nucleus #chromatin accessibility and #transcriptome profiling

h/t @albacorp7.bsky.social congratulations 🎉🍾

Model describing how daily rhythmic O-GlcNAc proteome integrates environmental and metabolic signals to regulate transcriptomic and physiological rhythms. Environmental cues signaling through the molecular clock and metabolic cues from feeding–fasting cycles regulate daily rhythms in the O-GlcNAc proteome. Rhythmic O-GlcNAcylation can directly shape daily rhythmicity in transcriptome and physiology. In addition, rhythmic O-GlcNAcylation can also interact with rhythmic phosphorylation. Different forms of crosstalk between O-GlcNAc proteome and phosphoproteome are shown in the middle box. The red solid arrows indicate the regulations described in this study, while the dashed arrow indicates regulations discovered by previous studies. Figure created using BioRender.com.

The liver #transcriptome is highly sensitive to metabolic cues. By characterizing nuclear protein #OGlcNAcylation in mouse #liver during the day, @joanna-chiu.bsky.social &co show how shifts in a nutrient-sensitive #PTM may shape transcriptional regulation @plosbiology.org 🧪 plos.io/3KuS7m1

Model describing how daily rhythmic O-GlcNAc proteome integrates environmental and metabolic signals to regulate transcriptomic and physiological rhythms. Environmental cues signaling through the molecular clock and metabolic cues from feeding–fasting cycles regulate daily rhythms in the O-GlcNAc proteome. Rhythmic O-GlcNAcylation can directly shape daily rhythmicity in transcriptome and physiology. In addition, rhythmic O-GlcNAcylation can also interact with rhythmic phosphorylation. Different forms of crosstalk between O-GlcNAc proteome and phosphoproteome are shown in the middle box. The red solid arrows indicate the regulations described in this study, while the dashed arrow indicates regulations discovered by previous studies. Figure created using BioRender.com.

The liver #transcriptome is highly sensitive to metabolic cues. By characterizing nuclear protein #OGlcNAcylation in mouse #liver during the day, @joanna-chiu.bsky.social &co show how shifts in a nutrient-sensitive #PTM may shape transcriptional regulation @plosbiology.org 🧪 plos.io/3KuS7m1

Model describing how daily rhythmic O-GlcNAc proteome integrates environmental and metabolic signals to regulate transcriptomic and physiological rhythms. Environmental cues signaling through the molecular clock and metabolic cues from feeding–fasting cycles regulate daily rhythms in the O-GlcNAc proteome. Rhythmic O-GlcNAcylation can directly shape daily rhythmicity in transcriptome and physiology. In addition, rhythmic O-GlcNAcylation can also interact with rhythmic phosphorylation. Different forms of crosstalk between O-GlcNAc proteome and phosphoproteome are shown in the middle box. The red solid arrows indicate the regulations described in this study, while the dashed arrow indicates regulations discovered by previous studies. Figure created using BioRender.com.

The liver #transcriptome is highly sensitive to metabolic cues. By characterizing nuclear protein #OGlcNAcylation in mouse #liver during the day, @joanna-chiu.bsky.social &co show how shifts in a nutrient-sensitive #PTM may shape transcriptional regulation @plosbiology.org 🧪 plos.io/3KuS7m1

New in the September issue of #G3journal: Lei et al. reanalyzed #transcriptome data from thousands of #maize to uncover the genetics underlying maize complex traits, and built a multi-tissue regulatory atlas for functional validation and genomic improvements. buff.ly/nLTUrTm

A research team published their findings in Horticulture Research. The study investigated how non-photosynthetic grapevine cells adapt to glucose deprivation.
#DNA methylation #Transcriptome
Details: doi.org/10.1093/hr/u...

New in #G3journal: Lei et al. reanalyzed #transcriptome data from thousands of #maize panels to uncover the genetics underlying maize complex traits, and built a multi-tissue regulatory atlas for functional validation and genomic improvements. buff.ly/9PUe5CW

Graphic showing a Circos plot of the genome and a drawing of the medicinal plant Hemiboea subcapitata, with "Facultative adaptation" underneath it and dashed lines to either side. The left side reads "non-karst" and leads to a bar graph depicting whole-genome duplications. the right side reads "karst" and leads to a diagram of gene regulation, showing various players forming MBW complexes.

Wang et al. explore #adaptation to #karst geology in the medicinal plant Hemiboea subcapitata using a #chromosome level #genome and #transcriptome analysis, revealing effects on flavonoid metabolism. #plantscience #evolution
doi.org/10.1111/jse....

Full-length #Transcriptome revealed a new isoform, ERBB2-i14e, associated with #GallbladderCancer (GBC) progression, worse #prognosis, & #Trastuzumab resistance, highlighting it as a #Biomarker & #TherapeuticTarget for GBC. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Molecular dissection of Xinong 511 spike rachis response to Fusarium head blight infection - Stress Biology Fusarium head blight (FHB, also known as wheat scab or ear blight), caused primarily by the Fusarium graminearum, is a worldwide disease of wheat (Triticum aestivum L.). Studying the pathogen expansio...

Molecular dissection of Xinong 511 spike rachis response to Fusarium head blight infection
Xiaoying Yang, Maoru Xu ... Chunhuan Chen, Wanquan Ji

link.springer.com/article/10.1...

#FHB #transcriptome #DiseaseResistance #PlantImmunity

The arms and heads of opossums (pictured here one day before birth ) and other marsupials develop faster than their legs and back bodies. Image credit: Sergio Menchero Fernandez/ Francis Crick Institute, London.

In #opossums and other #marsupials, #GeneExpression follows familiar rules, but at an unusual pace. In PNAS Journal Club: www.pnas.org/post/journal...

#DevelopmentalBiology #evolution #embryo #transcriptome

Hamsters with long COVID present distinct transcriptomic profiles associated with neurodegenerative processes in brainstem | Nature Communications #covid19 #longcovid #neurons #transcriptome #brainstem

Using integrated #transcriptome and proteome analyses, scientists from @emorydeptofmed.bsky.social identified and validated eight novel non-classical #CDMarkers that help characterize #MesenchymalStemCells and potentially discriminate #iMSCs from other cell types.
#OpenAccess:
buff.ly/vnN9LqA

In a study published in Horticulture Research, researcher performed full-length transcriptome sequencing on chili pepper tissues at five growth stages.
#plant developmental biology #transcriptome sequencing
Details: doi.org/10.1093/hr/uhae198