Guilt. Justice. Redemption.

In Crime and Punishment, Dostoevsky takes readers deep into the mind of a man convinced he can outrun morality itself. 

This #tuesdayreads step into one of literature's most powerful psychological novels - https://casacarlini.com/product/crime-and-punishment/

A hand holds a paperback copy of The Mysterious Correspondent by Marcel Proust. The cover is designed with contrasting black and cream blocks and includes two vintage-style photographs of a young Proust. The background is softly out of focus, with warm lighting and a leafy plant visible.

This week’s #TuesdayBookClub pick is The Mysterious Correspondent by Marcel Proust. Short stories and fragments that draw you back into a world of nuance, memory, and emotional depth—a reminder that slowness can be radical. #MarcelProust #TuesdayReads #Booksky
p-wavepress.co.uk/blog/files/t...

In White Nights, Dostoevsky reminds us that even the briefest encounters, the smallest dreams, the most fragile hopes...are stories worth telling. 

Because to live is to gather stories - even the ones that ache. 

#casacarlinibooks #dostoevsky #tuesdayreads

Was the film cursed? Was the mask cursed? Is the world cursed? What did you think about the ending of Horror Movie by Paul Tremblay?
#bookquotes #quote #horrorbooks #readers 💙 📚 🩸 #tuesdayreads #bookclub

Hope you’re having a terrific Tuesday!

#TuesdayThrowback
#readingcommunity #cozy #suspense #Tuesdayreads

Slow rollout throttled Biden’s big clean energy ambitions, former staffers say An “executive branch machinery that defaulted to caution, process, and reactive strategies” undercut the ex-president’s massive energy and infrastructure programs, a report by his former staffers deta...

#TuesdayReads: Policymakers on why Biden's #CleanEnergy policies failed to take off -- and what to do if we ever get another chance 🙏.

Discover Jivavarta, Shon Mehta’s rich fictional world! Explore standalone novels like The Timingila, Lair of the Monster, & Lores of Jivavarta for deep philosophical tales & adventure. #Jivavarta #fantasy #fantasybooks #TuesdayReads

Discover Jivavarta, Shon Mehta’s rich fictional world! Explore standalone novels like The Timingila, Lair of the Monster, & Lores of Jivavarta for deep philosophical tales & adventure. #Jivavarta #fantasy #fantasybooks #TuesdayReads

Discover Jivavarta, Shon Mehta’s rich fictional world! Explore standalone novels like The Timingila, Lair of the Monster, & Lores of Jivavarta for deep philosophical tales & adventure.

#Jivavarta #fantasy #fantasybooks #TuesdayReads

Mr Bridge by Evan S. Connell Walter Bridge, husband to India and father to three, is a successful lawyer in a Kansas suburb. The daily dramas of his life only serve to illuminate his prejudice, self doubts and narrow outlook - his Christmas gifts to the family are stock certificates, which he immediately takes back to manage on their behalf - yet he is also kind and charitable, loving his wife while never able to tell her so. In Mr Bridge, Evan S. Connell gives us a moving, satirical and poetic portrayal of a man who cannot escape his limitations, and a couple growing old together but unable, ultimately, to connect.

‘The man is no good. He's no good, I tell you. He never was any good. He never will be any good!'’

Mr Bridge is in no doubt about Senator Horton Bailey. Do we know if he is blue or red? I suspect blue! 💙📚 #BookSky #AmReading #TuesdayReads #TBR

The Authoritarian Playbook, Part 2: When “Temporary” Emergencies Never End From Orbán to the Patriot Act, Citizen of Europe explains how “temporary” emergencies become permanent rule — Part 2 of The Authoritarian Playbook.

Authoritarian Playbook, Part 2
“Temporary” emergencies rarely end. From Orbán to the Patriot Act — the tactic repeats.

#Democracy #Authoritarianism #EmergencyPowers #TuesdayReads

Building electrification and fast, affordable construction can coexist Opponents of gas bans and all-electric building requirements say they’ll make housing unaffordable. That doesn’t have to be true.

💡⚡🔋 #TuesdayReads Building electrification does not have to be expensive.

#electrifyeverything
#climatejustice

Immunoassay for pyruvate kinase M1/2 as an Alzheimer’s biomarker in CSF Alzheimer’s disease (AD) is characterized by amyloid-beta plaques and tau tangles in the brain, but these markers alone do not predict disease progression. The intersection of these pathologies with o...

#TuesdayReads:
Becky Carlyle et al develop and validate an ELISA to measure PKM in cerebrospinal fluid—linking elevated levels to accelerated cognitive decline in Alzheimer’s and highlighting PKM as a potential early biomarker.
🔗 www.degruyterbrill.com/document/doi...

Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP - Nature Communications Chagas disease, caused by Trypanosoma cruzi, lacks an effective vaccine. Here, the authors report the cryo-EM structure of TcPOP, a potential vaccine antigen, in open and closed states and validate it...

#TuesdayReads:
Struwe Group et al reveal the structure of a key Trypanosoma cruzi enzyme, TcPOP, and show its potential as a Chagas disease vaccine target through invasion-blocking immune responses.
🔗 www.nature.com/articles/s41...
#ChagasDisease #VaccineResearch #CryoEM #ParasiteBiology

Single-Molecule Imaging for Unraveling the Functional Diversity of 10–23 DNAzymes DNA-based enzymes, also known as DNAzymes, have opened new opportunities for signal generation and amplification in several fields including biosensing. However, biosensor performance can be hampered ...

#TuesdayReads:
Kapanidis Group et al present a single-molecule approach to study DNAzymes—revealing functional diversity and uncovering performance differences masked in bulk measurements, with implications for biosensing.
🔗 pubs.acs.org/doi/10.1021/...

The molecular circadian clock: From fundamental mechanisms to therapeutic promise in neurological disorders Circadian rhythms are intrinsic biological processes in all forms of life, governed by a molecular clock, organising physiological and behavioural cyc…

#TuesdayReads:
The Jagannath Group reviews the genetic and molecular workings of the circadian clock—highlighting how rhythm disruptions contribute to neurological disease and how targeting circadian mechanisms may offer new therapies.
🔗 www.sciencedirect.com/science/arti...

Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics - Nature Structural & Molecular Biology In this study, Rödström et al. use cryo-EM to reveal a range of structural features in THIK-1 K+ channel and demonstrate how these features define many functional properties of the channel, thus expan...

#TuesdayReads:
In a multi-institutional collaboration, the Stephen Tucker & Simon Newstead Groups help reveal the structure of THIK-1, offering insights into its role in #neuroinflammation and therapeutic potential.
🔗 www.nature.com/articles/s41...
#CryoEM #IonChannels #ALS #Alzheimers

#TuesdayReads:
Draper Group et al reveal how disease tolerance to malaria develops after just one infection—reprogramming T cell responses to reduce inflammation without compromising memory.

rupress.org/jem/article/...

#Malaria #Immunology #DiseaseTolerance #TCellResponse @kavlifoundation.org

Permanent magnetic droplet–derived microrobots Permanent magnetic droplet–derived microrobots have enhanced cargo loading and locomotion capabilities.

#TuesdayReads:

Molly Stevens et al introduce magnetic microrobots with programmable movement and high cargo capacity—offering a powerful platform for precision drug delivery and clinical translation.

🔗 www.science.org/doi/10.1126/...

#Microrobots #PrecisionMedicine #Bioengineering #DrugDelivery

Turn the shadows into stories. Discover gods, monsters & ancient origins.
📖 mybook.to/TheShadowsof...
🌍 www.thepangeanchronicles.com
⚔️ Life Stones – Coming Soon
#ShadowsOfPangea #ComingSoon #FantasyLore #TuesdayReads

RIFINs displayed on malaria-infected erythrocytes bind KIR2DL1 and KIR2DS1 - Nature Certain RIFINs from Plasmodium falciparum can bind to both inhibitory (KIR2DL1) and activating (KIR2DS1) immune receptors on natural killer cells, demonstrating the potential role of activating killer...

#TuesdayReads:
Matt Higgins et al uncover how RIFIN proteins from Plasmodium falciparum interact with NK cell receptors—dampening or activating immune responses—and highlight a potential role for activating receptors in malaria control.
🔗 www.nature.com/articles/s41...

#TuesdayReads:
Yuanxiong Cao et al from the Stevens Group review how organ-on-a-chip technologies could transform comorbidity research, using CKD and osteoarthritis as a case study for personalised therapy development.
🔗 advanced.onlinelibrary.wiley.com/doi/10.1002/...

Before the gods fell, the shadows stirred.
Begin the legend with The Shadows of Pangea.
✨ Life Stones is coming soon...
📖 mybook.to/shadowsofpan...
🌍 www.thepangeanchronicles.com
#ShadowsOfPangea #EpicFantasy #TuesdayReads

Tackle your Tuesday with demon agents, ancient gods, and epic battles.
📚 Dive into The Pangean Chronicles
🔗 www.amazon.co.uk/dp/B0DBNYR2Q....
🌍 www.thepangeanchronicles.com
#yafiction #urbanfantasybooks #pangeasaga #TuesdayReads #booksbooksbooks

SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides SARM1 is a key regulator of a conserved program of axon degeneration increasingly linked to human neurodegenerative diseases. Pathological SARM1 activ…

#TuesdayReads:
The @WadeMartinsLab shows how antisense oligonucleotides targeting SARM1 protect human neurons from axon degeneration—highlighting a promising therapeutic approach for neurodegenerative disease.

🔗 www.sciencedirect.com/science/arti...

Formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons - npj Parkinson's Disease npj Parkinson's Disease - Formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons

#TuesdayReads:
Brent Ryan was part of a collaboration to show how parkin deficiency drives α-synuclein aggregation, release, and synaptic loss in Parkinson’s models—challenging the view of PARK2-related PD as a non-synucleinopathy.
🔗 doi.org/10.1038/s415...

#TuesdayReads:
The Zitzmann Group collaborate with the Rutherford Appleton Laboratory to explore how Spatially Offset Raman Spectroscopy (SORS) could screen medicinal syrups for harmful contaminants like DEG and EG—rapidly and non-invasively, even through closed containers.

doi.org/10.1016/j.jp...

#TuesdayReads:
Mark Hankins et al explores how optogenetic gene therapy could restore vision in retinal disorders and how it might interact with remaining native vision—insights that could shape future clinical trials. 👇

insight.jci.org/articles/vie...

Single-Molecule Imaging for Unraveling the Functional Diversity of 10–23 DNAzymes DNA-based enzymes, also known as DNAzymes, have opened new opportunities for signal generation and amplification in several fields including biosensing. However, biosensor performance can be hampered by heterogeneity in the catalytic activity of such DNAzymes, especially when relying on a limited number of molecules to generate signal. In this regard, single-molecule studies are essential to discern the behavior among such heterogeneous molecules otherwise masked by ensemble measurements. This work presents a novel methodology to study the 10–23 RNA-cleaving DNAzyme at the single-molecule level. By means of measuring the distance-sensitive efficiency of Förster Resonance Energy Transfer using alternating-laser excitation on a superresolution microscope, we determined the kinetics of individual DNAzymes in terms of substrate turnover, rates of different reaction steps, and changes in performance over time. Our results revealed that, despite high concentrations of the reaction cofactor (i.e., Mg2+), a maximum of only 70% of the DNAzymes are actively cleaving multiple substrate sequences; the DNAzyme molecules also showed a wide range of substrate turnover rates. Our findings shed new light on the functional diversity of DNAzymes and the importance of exploring sequence modifications to improve their catalytic performance. Ultimately, this work presents a technique to obtain time-dependent information, which could be easily implemented to study other types of enzymes or biomolecular interactions.

#TuesdayReads:
Kapanidis Group highlights a single-molecule approach to uncover the functional diversity of DNAzymes, offering insights to improve their catalytic performance for biosensing. 👇
pubs.acs.org/doi/10.1021/...

Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential - Molecular Neurodegeneration Extracellular vesicles (EVs) are membrane-enclosed nanoparticles released by most cell types, and from multiple sub-cellular compartments. They carry a range of cargo biomolecules, including protein a...

#TuesdayReads:

A new review from the Talbot Group explores how extracellular vesicles carrying TDP-43 may influence ALS and FTD pathology—and their potential as biomarkers in neurodegenerative disease. 👇

molecularneurodegeneration.biomedcentral.com/articles/10....

🖤 Start something unforgettable this Tuesday
Long before the world you know…
A child changed everything.
The Shadows of Pangea is where the story begins.
🔗 mybook.to/shadowsofpan...
🌐 www.thepangeanchronicles.com
#ShadowsOfPangea #TuesdayReads #FantasyBooks #StartReading #DarkFantasy